{"id":56,"date":"2018-11-02T17:47:45","date_gmt":"2018-11-02T17:47:45","guid":{"rendered":"http:\/\/depts.washington.edu\/kellylab\/wordpress\/?page_id=56"},"modified":"2020-04-30T17:43:39","modified_gmt":"2020-04-30T17:43:39","slug":"publications","status":"publish","type":"page","link":"http:\/\/depts.washington.edu\/kellylab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

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Publications<\/h1>\n

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<\/span><\/i> 2020<\/a><\/h3>
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Tissue Chips in Space-Challenges and Opportunities.<\/strong>
\nYeung CK, Koenig P, Countryman S, Thummel KE, Kelly EJ.
\nClinical and Translational Science<\/i>, 2020, 13 (1), 31524321.
\nView on PubMed<\/a><\/p>\n

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Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling.<\/strong>
Sakolish, C, Chen, Z, Dalaijamts, C, Mitra, K, Liu, Y, Fulton, T, Wade, TL, Kelly, EJ, Rusyn, I & Chiu, WA.
Toxicology In Vitro<\/i>, 2020, 63:104752, 31857146.
View on PubMed<\/a><\/p>\n

An improved vascularized, dual-channel microphysiological system facilitates modeling of proximal tubular solute secretion.<\/strong>
Chapron, A, Chapron, BD, Hailey, DW, Chang, SY, Imaoka, T, Thummel, KE, Kelly, EJ, Himmelfarb, J, Shen, D & Yeung, CK.
ACS Pharmacology & Translational Science<\/i>, 2020, 3 (3), 32566915.
View on PubMed<\/a><\/p>\n

Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism.<\/strong>
Zhang, A, Li, CY, Kelly, EJ, Sheppard, L & Cui, JY.
PLoS One<\/i>, 2020, 15 (2), 32101552.
View on PubMed<\/a><\/p>\n

Microphysiological system modeling of ochratoxin A-associated nephrotoxicity.<\/strong>
Imaoka, T, Yang, J, Wang, L, McDonald, MG, Afsharinejad, Z, Bammler, TK, Van Ness, K, Yeung, CK, Rettie, AE, Himmelfarb, J & Kelly, EJ.
Toxicology<\/i>, 2020, 444:152582, 32905824.
View on PubMed<\/a><\/p>\n

Characterization of differential tissue abundance of major non-CYP enzymes in human.<\/strong>
Basit, A, Neradugomma, NK, Wolford, C, Fan, PW, Murray, B, Takahashi, RH, Khojasteh, SC, Smith, BJ, Heyward, S, Totah, RA, Kelly, EJ & Prasad, B.
Molecular Pharmaceutics<\/i>, 2020, 17 (11), 32955894.
View on PubMed<\/a><\/p>\n

A multi compartment human kidney proximal tubule-on-a-chip replicates cell polarization-dependent cisplatin toxicity.<\/strong>
Nieskens, TTG, Persson, M, Kelly, EJ & Sj\u00f6gren, AK.
Drug Metabolism and Disposition<\/i>, 2020, doi: 10.1124\/dmd.120.000098, 33020068.
View on PubMed<\/a><\/p>\n

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<\/span><\/i> 2019<\/a><\/h3>
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A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda.<\/strong>
\nPatel, RC, Stalter, RM, Thomas, KK, Tamraz, B, Blue, SW, Erikson, DW, Kim, CJ, Kelly, EJ, Nanda, K, Kourtis, AP, Lingappa, JR, Mugo, N, Baeten, JM, Scarsi, KK; Partners PrEP Study Team.
\nAIDS<\/i>, 2019, 33 (13), 31306173.
\nView on PubMed<\/a><\/p>\n

Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells.<\/strong>
\nSachar, M, Kelly, EJ & Unadkat, JD.
\nThe AAPS Journal<\/i>, 2019, 21 (3), 30919109.
\nView on PubMed<\/a><\/p>\n

Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System.<\/strong>
\nMaass, C, Sorensen, NB, Himmelfarb, J, Kelly, EJ, Stokes, CL & Cirit, M.
\nCPT Pharmacometrics Systems Pharmacology<\/i>, 2019, 8 (5), 30869201.
\nView on PubMed<\/a><\/p>\n

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<\/span><\/i> 2018<\/a><\/h3>
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\nHuman kidney on a chip assessment of polymyxin antibiotic nephrotoxicity.<\/strong>
Weber EJ, Lidberg KA, Wang L, Bammler TK, MacDonald JW, Li MJ, Redhair M, Atkins WM, Tran C, Hines KM, Herron J, Xu L, Monteiro MB, Ramm S, Vaidya V, Vaara M, Vaara T, Himmelfarb J, Kelly EJ.
The Journal of Clinical Investigation Insight<\/i>, 2018, 3 (24), e123673.
View on PubMed<\/a><\/p>\n

Author's Take<\/p>\n

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\nReconstructing the human renal vascular-tubular unit in vitro.
<\/strong>Rayner SG, Phong KT, Xue J, Lih D, Shankland SJ, Kelly EJ, Himmelfarb J, Zheng Y.
Advanced Healthcare Materials<\/em>, 2018, 7 (23), e1801120.
View on PubMed<\/a>
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A high-throughput screen identifies DYRK1A inhibitor ID-8 that stimulates human kidney tubular epithelial cell proliferation.
<\/strong>Monteiro MB, Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS.
Journal of the American Society of Nephrology<\/em>, 2018, 29 (12), 2820-2833.
View on PubMed<\/a><\/p>\n

Technology transfer of the microphysiological systems: A case study of the human proximal tubule tissue chip.
<\/strong>Sakolish C, Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I.
Scientific Reports<\/em>, 2018, 8 (1), 14882.
View on PubMed<\/a><\/p>\n

Emerging kidney models to investigate metabolism, transport, and toxicity of drugs and xenobiotics.
<\/strong>Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G.
Drug Metabolism and Disposition<\/em>, 2018, 46 (11), 1692-1702.
View on PubMed<\/a><\/p>\n

Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system.
<\/b>Chapron BD, Chapron A, Phillips B, Okoli MC, Shen DD, Kelly EJ, Himmelfarb J, Thummel KE.
Alternatives to Animal Experimentation<\/em>, 2018, 35 (4), 504-515.
View on PubMed<\/a><\/p>\n

Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2.
<\/b>Lockhart CM, Smith TB, Yang P, Naidu M, Rettie AE, Nath A, Weleber R, Kelly EJ.
British Journal of Ophthalmology<\/em>, 2018, 102 (2), 187-194.
View on PubMed<\/a><\/p>\n

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<\/span><\/i> 2017<\/a><\/h3>
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\nHuman liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity.
<\/strong>Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquiest TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL.
The Journal of Clinical Investigation Insight<\/em>, 2017, 2 (22), e95978.
View on PubMed<\/a><\/p>\n

Concise Review: Current and emerging biomarkers of nephrotoxicity.
<\/b>Weber EJ, Himmelfarb J, Kelly EJ.
Current Opinion in Toxicology<\/em>, 2017, 4, 16-21.
View on PubMed<\/a><\/p>\n

Microphysiological systems to assess nonclinical toxicity.<\/strong>
Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ.
Current Protocols in Toxicology<\/em>, 2017, 73 (1), 11.23.1-22.5.22.
View on PubMed<\/a><\/p>\n

Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity.<\/strong>
Chang SY, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL.
Toxicology In Vitro<\/em>, 2017, 40, 170-183.
View on PubMed<\/a><\/p>\n

Functional coupling of human microphysiology systems: Intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle.
<\/b>Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL.
Scientific Reports<\/em>, 2017, 8 (7), 42296.
View on PubMed<\/a><\/p>\n

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<\/span><\/i> 2016<\/a><\/h3>
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\nAbundance of drug transporters in the human kidney cortex as quantified by quantitative targeted proteomics.
<\/b>Drug Metabolism and Disposition<\/em>, 2016, 44 (12), 1920-1924.
View on PubMed<\/a><\/p>\n

Transporter expression in liver tissue from subjects with alcoholic or hepatitis C cirrhosis quantified by targeted quantitative proteomics.
<\/b>Wang L, Collins C, Kelly EJ, Chu,X, Ray AS, Salphati L, Xiao G, Lee C, Lai Y, Liao,M, Mathias A, Evers R, Humphreys G, Hop CE, Kumer SC, Unadkat JD.
Drug Metabolism and Disposition<\/i>, 2016, 44 (11), 1752-1758.
View on PubMed<\/a><\/p>\n

Development of a microphysiological model of human kidney proximal tubule function.
<\/b>Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura,Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski,KA, Himmelfarb J, Kelly EJ.
Kidney International<\/em>, 2016, 90 (3), 627-637. (Article featured on journal cover)
View on PubMed<\/a><\/p>\n

Liver and kidney on chips: Microphysiological models to understand transporter function.
<\/strong>Chang SY, Weber EJ, Ness KV, Eaton DL, Kelly EJ.
Clinical Pharmacology and Therapeutics<\/em>, 2016, 100 (5), 464-478.
View on PubMed<\/a><\/p>\n

Pharmacokinetics of metoprolol during pregnancy and lactation.
<\/b>Ryu RJ, Eyal S, Easterling,TR, Caritis SN, Venkataraman R, Hankins G, Rytting E, Thummel K, Kelly EJ, Risler L, Phillips B, Honaker MT, Shen DD, Hebert MF.
Journal of Clinical Pharmacology<\/em>, 2016, 56 (5), 581-589.
View on PubMed<\/a><\/p>\n

Species differences in microsomal oxidation and glucuronidation of 4-ipomeanol: Relationship to target organ toxicity.<\/strong>
Parkinson OT, Teitelbaum AM, Whittington D, Kelly EJ, Rettie AE.
Drug Metabolism and Disposition<\/em>, 2016, 44 (10), 1598-1602.
View on PubMed<\/a><\/p>\n

A quantitative approach to screen for nephrotoxic compounds in vitro.
<\/b>Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS.
Journal of the American Society of Nephrology<\/em>, 2016,\u00a0 27(4), 1015-1028.
View on PubMed<\/a><\/p>\n

Pharmacogenetic profiling and metabolic activity of human embryonic stem cell derived hepatocytes: focus on CYP450-mediated oxidation.
<\/b>Voellinger JL, Kelly EJ.
ADMET and DMPK<\/em>, 2016, 4(2), 62-83.
View on IAPChem<\/a><\/p>\n

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<\/span><\/i> 2015<\/a><\/h3>
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\nIdentification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.
<\/b>Wiek C, Schmidt EM, R\u00f6llecke K, Nakano M, Kelly EJ, Kaisers W, Yarov-Yarovoy V, Rettie AE, Hanenberg H.
Biochemical Journal<\/em>, 2015,\u00a0 465 (1), 103-114. 2015.
View on PubMed<\/a><\/p>\n

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<\/span><\/i> 2014<\/a><\/h3>
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\nIdentification of CYP3A7 for glyburide metabolism in human fetal livers.
<\/b>Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat, JD, Hebert MF, Shen,DD, Thummel KE, Mao Q.
Biochemical Pharmacology<\/em>, 2014, 92 (4), 690-700. 2014.
View on PubMed<\/a><\/p>\n

Generation and characterization of a murine model of Bietti Crystalline Dystrophy.
<\/b>Lockhart CM, Nakano M, Rettie AE, Kelly EJ.
Investigative Ophthalmology & Visual Science<\/em>, 2014, 55 (9), 5572-5581.
View on PubMed<\/a><\/p>\n

Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition.
<\/b>Nakano M, Lockhart CM, Kelly EJ, Rettie AE.
Drug Metabolism Reviews<\/em>, 2014, 46 (3), 247-260.
View on PubMed<\/a><\/p>\n

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<\/span><\/i> 2013<\/a><\/h3>
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\nInnovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system.
<\/strong>Kelly EJ, Wang Z, Voellinger JL, Yeung CK, Shen DD, Thummel KE, Zheng Y, Ligresti G, Eaton DL, Muczynski KA, Duffield JS, Neumann T, Tourovskaia A, Fauver M, Kramer G, Asp E, Himmelfarb J.
Stem Cell Research & Therapy<\/em>, 2013, 4 (1), S17.
View on PubMed<\/a><\/p>\n

Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy.
<\/b>Lee N, Hebert MF, Prasad B, Easterling TR, Kelly EJ, Unadkat JD, Wang J.
Drug Metabolism and Disposition<\/em>, 2013, 41 (12), 2225-2232.
View on PubMed<\/a><\/p>\n

Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of ipomeanol.
<\/b>Parkinson OT, Liggitt HD, Rettie AE, Kelly EJ.
Toxicological Sciences<\/em>, 2013, 134 (2), 243-250.
View on PubMed<\/a><\/p>\n

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