Sylvia LaCourse, MD, MPH

Assistant Professor in the Department of Medicine, Division of Allergy and Infectious Diseases

Sylvia LaCourse MD, MPH. is currently an Assistant Professor in the Department of Medicine, Division of Allergy and Infectious Diseases. Her current research focuses on improving TB prevention and screening in maternal child health settings. LaCourse realized her interest in global health initially as a Peace Corps volunteer in Senegal. Returning to the U.S. she completed post-bac pre-med courses and received her MD from the University of Louisville. During her residency in Internal Medicine/Pediatrics at Brown University, she participated in numerous clinical rotations in Kenya, Burundi, Haiti and Malawi, and helped to organize a refugee primary care clinic. She returned to Malawi as a NIH Fogarty International Clinical Research Fellow, where her research focused on the performance of GeneXpert (rapid tuberculosis PCR-based diagnostic) in severely malnourished hospitalized children, and implementation research on counselor-initiated HIV testing of hospitalized adults and pediatric malnutrition screening using lay-screeners.Sylvia has recently completed her fellowship in Infectious Diseases and MPH in Epidemiology-International Health. Under the mentorship of Dr. Grace John-Stewart (Global Health, Epidemiology, Medicine, Pediatrics) and in collaboration with Dr. David Horne (Pulmonary-Critical Care), her research focuses on HIV/TB in pregnancy including prevalence and correlates of active and latent TB and identifying optimal screening algorithms among HIV-infected pregnant women including the evaluation of Xpert and TB-LAM (rapid urine TB antigen test), as well as the incidence of interferon-gamma release assay (IGRA, Mycobacterium tuberculosis infection diagnostic) conversion among HIV-infected pregnant women in Kenya from a historical cohort. She is PI of a UW CFAR International Pilot Study evaluating the performance of M. tuberculosis infection diagnostics in pregnant and early postpartum HIV-infected women. During her MPH she conducted a retrospective study evaluating the risk of adverse infant outcomes associated with maternal TB in Washington State, and evaluation of the implementation of isoniazid preventive therapy in HIV-infected Kenyan female sex workers with Dr. Scott McClelland (Medicine, Global Health, Epidemiology). She has recently been awarded a UW CFAR New Investigator Award: Oral swab analysis (OSA) for TB diagnosis in women, adolescents, and HIV-infected individuals in collaboration with Grace John-Stewart and Gerard Cangelosi (Environmental and Occupational Health). She has also recently been awarded a NIH/NIAID K23 Mentored Patient-Oriented Research Career Development Award to study the impact of maternal HIV on Mycobacterium tuberculosis (Mtb) infection among peripartum women and their infants in western Kenya.

Publications

  1. Cherkos, AS, LaCourse, SM, Enquobahrie, DA, Escudero, JN, Mecha, J, Matemo, D et al.. Isoniazid preventive therapy during infancy does not adversely affect growth among HIV-exposed uninfected children: Secondary analysis of data from a randomized controlled trial. PLoS One. 2024;19 (8):e0293708. doi: 10.1371/journal.pone.0293708. PubMed PMID:39150949 PubMed Central PMC11329125.
  2. Bijker, EM, Horn, L, LaCourse, S, MacLean, EL, Marais, BJ, Nicol, MP et al.. The inclusion of children and adolescents in tuberculosis diagnostic development and evaluation-a consensus statement. Lancet Infect Dis. 2024; :. doi: 10.1016/S1473-3099(24)00339-6. PubMed PMID:38971177 .
  3. LaCourse, SM, Wetzler, EA, Aurelio, MC, Escudero, JN, Selke, SS, Greninger, AL et al.. Hybrid Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 During Pregnancy Provides More Durable Infant Antibody Responses Compared to Natural Infection or Vaccination Alone. J Infect Dis. 2024;229 (4):1241-1243. doi: 10.1093/infdis/jiae046. PubMed PMID:38285008 .
  4. LaCourse, SM, Wetzler, EA, Aurelio, MC, Escudero, JN, Selke, SS, Greninger, AL et al.. Hybrid Immunity to SARS-CoV-2 During Pregnancy Provides More Durable Infant Antibody Responses Compared to Natural Infection Alone. J Infect Dis. 2024;229 (6):1728-1739. doi: 10.1093/infdis/jiad592. PubMed PMID:38128542 .
  5. Miele, K, Rock, RB, LaCourse, SM, Ashkin, D, Armitige, LY, Pomputius, W et al.. Notes from the Field: Undiagnosed Tuberculosis During Pregnancy Resulting in a Neonatal Death - United States, 2021. MMWR Morb Mortal Wkly Rep. 2023;72 (49):1331-1332. doi: 10.15585/mmwr.mm7249a4. PubMed PMID:38060433 PubMed Central PMC10715820.
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