HSV-2 Suppression among HIV-1-infected Pregnant Women

to Reduce Plasma and Genital HIV-1 Levels and Vertical Transmission of HIV-1

Funding: University of Washington Royalty Research Fund
PI: Carey Farquhar
Time period: 09/15/07-03/14/09

In this clinical trial, HIV-infected pregnant women in Nairobi who are HSV-2 seropositive will be randomized to valacyclovir or placebo antenatally.  HIV-1 RNA levels in plasma and genital secretions will be compared between treatment and placebo arms and maternal and infant toxicity will be assessed.

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