The role of immune activation and natural killer cells in acquisition and control of infant HIV-1

Funding: MV-00-9-900-01872-0-00 Elizabether Glaser Pediatric AIDS Foundation
PI: Barbara Lohman-Payne
Time Period: 01/01/2010 – 09-30-2012
 
The recent lack of success in the Merck Ad5 HIV-1 vaccine trial highlights the need to move beyond focusing on the adaptive cellular immune response. It is plausible that the innate immune responses and basal cellular activation play a role in acquisition and control of HIV-1. We propose a case control study drawn from an existing cohort of > 400 mother-infant pairs to determine the role of baseline infant immune activation and natural killer (NK) cell function on acquisition and control of HIV-1.
 
Link to study workspace (for those with access):  https://catalysttools.washington.edu/workspace/mbarrett/10166/
 

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