In-silico studies of genomic data will be an important area of biological research. With the progress of the genome projects, much remains to be done to extract the rich amount of information from the genomes. My research focuses on highly comprehensive analysis of genomic sequences, assisted by computer software, to identify features of the human genome responsible for uniquely human phenotypes, novel gene formation, gene structure evolution, gene death, exon recycling, bi-directional promoters, endogenous antisense transcription, and exon sharing as mechanisms of positionally based co-regulation of adjacent expressed features in humans. With these goals, I am performing in-silico discovery of novel, recently arisen, and lineage-specific genes and other transcriptional units in the human genome, as well as conducting detailed annotation of putative sequence-level regulatory relationships of multiple genes, and transcriptional units over large contiguous genomic regions. In addition, I also carry out in-lab genomic consulting, including customized gene structure determination and novel gene discovery for ongoing positional cloning projects.
An example of my work:
