We specialize in the mathematical modeling of pathological biosystems – specifically, primary brain tumors known as gliomas. We are currently working on several collaborative projects utilizing both clinical and experimental imaging techniques such as MRI and PET.
Our focus is on: 1) predicting patient-specific tumor growth, 2) seeking patient-specific markers of tumor progression, and, 3) identifying predictors of response to therapy in individual patients.
Brain Tumors–Gliomas
Gliomas are diffuse and invasive brain tumors with the nefarious ability to recur despite extensive surgical resection. Chemotherapies are also seldom successful due to hindrance by the intricate capillary structure of the blood brain barrier. Based on a simple mathematical model of glioma growth and diffusion, we developed a model incorporating information regarding tumor polyclonality and brain tissue heterogeneity to track the spread and control of malignant gliomas.
A movie showing the simulation of our model for glioma growth and invasion.
