Welcome to the L2L Microarray Analysis ToolA simple tool for discovering the hidden biological significance in microarray expression data. |
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| Results summary | View all lists in GO:MoleFunc | View all genes in ageing_brain_dn |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. | 402 | 5.38 | 19 | 3.53 | 3.17e-06 |
| calmodulin binding | Interacting selectively with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. | 139 | 1.86 | 11 | 5.91 | 3.21e-06 |
| purine nucleotide binding | Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate. | 1223 | 16.37 | 35 | 2.14 | 3.66e-05 |
| nucleotide binding | Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety. | 1232 | 16.49 | 35 | 2.12 | 4.22e-05 |
| ATPase activity, coupled to transmembrane movement of ions | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. | 76 | 1.02 | 7 | 6.88 | 7.51e-05 |
| phorbol ester receptor activity | Combining with a phorbol ester to initiate a change in cell activity. | 19 | 0.25 | 4 | 15.73 | 1.06e-04 |
| transporter activity | Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. | 1153 | 15.43 | 31 | 2.01 | 2.85e-04 |
| ATP binding | Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | 1018 | 13.63 | 28 | 2.05 | 3.83e-04 |
| adenyl nucleotide binding | Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. | 1030 | 13.79 | 28 | 2.03 | 4.58e-04 |
| GTPase activity | Catalysis of the hydrolysis of GTP to GDP and orthophosphate. | 137 | 1.83 | 8 | 4.36 | 5.59e-04 |
| ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. | 246 | 3.29 | 11 | 3.34 | 5.60e-04 |
| calcium-transporting ATPase activity | Catalysis of the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). | 13 | 0.17 | 3 | 17.24 | 6.20e-04 |
| P-P-bond-hydrolysis-driven transporter activity | Catalysis of the transport of a solute, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. | 145 | 1.94 | 8 | 4.12 | 8.11e-04 |
| calcium ion transporter activity | Enables the directed movement of calcium (Ca) ions into, out of, within or between cells. | 16 | 0.21 | 3 | 14.01 | 1.18e-03 |
| extracellular ligand-gated ion channel activity | 60 | 0.80 | 5 | 6.23 | 1.27e-03 | |
| ATPase activity, coupled | Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane. | 237 | 3.17 | 10 | 3.15 | 1.51e-03 |
| protein serine/threonine kinase activity | Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. | 376 | 5.03 | 13 | 2.58 | 1.97e-03 |
| phospholipid transporter activity | Enables the directed movement of phospholipids into, out of, within or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. | 20 | 0.27 | 3 | 11.21 | 2.31e-03 |
| ATPase activity, coupled to transmembrane movement of substances | Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance across a membrane. | 134 | 1.79 | 7 | 3.90 | 2.31e-03 |
| glutamate channel activity | 22 | 0.29 | 3 | 10.19 | 3.05e-03 | |
| cation transporter activity | Enables the directed movement of atoms or small molecules with a positive charge into, out of, within or between cells. | 184 | 2.46 | 8 | 3.25 | 3.61e-03 |
| ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. | 47 | 0.63 | 4 | 6.36 | 3.62e-03 |
| ion channel activity | Allows the regulatable energy-independent passage of ions across a lipid bilayer down a concentration gradient. | 232 | 3.11 | 9 | 2.90 | 4.43e-03 |
| diacylglycerol binding | Interacting selectively with diacylglycerol, a diester of glycerol and two fatty acids. | 50 | 0.67 | 4 | 5.98 | 4.53e-03 |
| ion transporter activity | Enables the directed movement of charged atoms or small charged molecules into, out of, within or between cells. | 233 | 3.12 | 9 | 2.89 | 4.55e-03 |
| acyl-CoA or acyl binding | Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thioester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid. | 52 | 0.70 | 4 | 5.75 | 5.21e-03 |
| primary active transporter activity | Catalysis of transport of a solute against a concentration gradient using a primary energy source. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources. | 197 | 2.64 | 8 | 3.03 | 5.42e-03 |
| phosphotransferase activity, alcohol group as acceptor | Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). | 629 | 8.42 | 17 | 2.02 | 5.72e-03 |
| hormone activity | Any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects. | 85 | 1.14 | 5 | 4.39 | 5.82e-03 |
| calcium ion binding | Interacting selectively with calcium ions (Ca2+). | 433 | 5.80 | 13 | 2.24 | 6.38e-03 |
| ligand-gated ion channel activity | 89 | 1.19 | 5 | 4.20 | 7.05e-03 | |
| alpha-type channel activity | Allows the movement of solutes by energy-independent process by passage through a transmembrane aqueous pore. Usually consist of alpha-helical membrane spanners, although beta-strands may be present and contribute to channel. | 251 | 3.36 | 9 | 2.68 | 7.29e-03 |
| channel/pore class transporter activity | Allows facilitated diffusion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without a carrier-mediated mechanism. They do not exhibit stereospecificity but may be specific for a particular molecular species or class of molecules. | 253 | 3.39 | 9 | 2.66 | 7.65e-03 |
| hydrogen-transporting ATP synthase activity, rotational mechanism | Catalysis of the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. | 32 | 0.43 | 3 | 7.00 | 8.90e-03 |
| hydrogen-transporting ATPase activity, rotational mechanism | Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. | 33 | 0.44 | 3 | 6.79 | 9.70e-03 |
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