Welcome to the L2L Microarray Analysis ToolA simple tool for discovering the hidden biological significance in microarray expression data. |
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| Results summary | View all lists in L2L MDB | View all genes in ageing_brain_up |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| ageing_brain_up | Age-upregulated in the human frontal cortex | 393 | 9.16 | 277 | 30.22 | 0.00e+00 |
| diab_neph_dn | Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls | 661 | 15.41 | 52 | 3.37 | 7.39e-14 |
| alzheimers_incipient_up | Upregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus | 424 | 9.89 | 37 | 3.74 | 1.35e-11 |
| alzheimers_disease_up | Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus | 1790 | 41.74 | 90 | 2.16 | 3.35e-11 |
| uvb_nhek1_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 372 | 8.68 | 24 | 2.77 | 1.00e-05 |
| diab_neph_up | Upregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls | 155 | 3.61 | 13 | 3.60 | 7.91e-05 |
| as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 22 | 0.51 | 5 | 9.75 | 1.30e-04 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 148 | 3.45 | 12 | 3.48 | 2.02e-04 |
| microrna_human | Predicted human MicroRNA targets | 2627 | 61.26 | 90 | 1.47 | 2.93e-04 |
| brca_er_pos | Genes whose expression is consistently positively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-positive tumors | 478 | 11.15 | 24 | 2.15 | 4.67e-04 |
| atria_up | Upregulated in the atria of healthy hearts, compared to venticles | 373 | 8.70 | 20 | 2.30 | 5.95e-04 |
| aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 81 | 1.89 | 8 | 4.24 | 6.20e-04 |
| microrna_mammal | Predicted MicroRNA targets conserved across human, mouse and rat | 1497 | 34.91 | 55 | 1.58 | 8.77e-04 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 89 | 2.08 | 8 | 3.85 | 1.16e-03 |
| brca_er_neg | Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors | 859 | 20.03 | 35 | 1.75 | 1.34e-03 |
| emt_up | Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 104 | 2.43 | 8 | 3.30 | 3.10e-03 |
| hdaci_colon_but48hrs_dn | Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 326 | 7.60 | 16 | 2.10 | 4.69e-03 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 163 | 3.80 | 10 | 2.63 | 5.21e-03 |
| adip_vs_fibro_dn | Downregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes | 51 | 1.19 | 5 | 4.20 | 6.65e-03 |
| tsadac_hypermeth_ovca_up | Genes with basally hypermethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells | 6 | 0.14 | 2 | 14.29 | 7.66e-03 |
| hdaci_compilation_up | Compilation of upregulated genes from all HDAC-inhibitor-related lists | 474 | 11.05 | 20 | 1.81 | 8.95e-03 |
| vegf_hmmec_up | Up-regulated at any time-point (3hrs, 6hrs, or 12hrs) follwing VEGF treatment of human myometrial microvascular endothelial cells | 126 | 2.94 | 8 | 2.72 | 9.70e-03 |
| htert_up | Upregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls | 56 | 1.31 | 5 | 3.83 | 9.83e-03 |
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