Welcome to the L2L Microarray Analysis ToolA simple tool for discovering the hidden biological significance in microarray expression data. |
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| Results summary | View all lists in GO:BiolProc | View all genes in alzheimers_dn |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| oxidative phosphorylation | The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. | 71 | 5.52 | 34 | 6.16 | 2.23e-19 |
| energy pathways | 277 | 21.54 | 62 | 2.88 | 3.48e-14 | |
| nucleoside triphosphate biosynthesis | The formation from simpler components of a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety. | 53 | 4.12 | 23 | 5.58 | 1.89e-12 |
| ribonucleoside triphosphate biosynthesis | The formation from simpler components of a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety. | 51 | 3.97 | 22 | 5.55 | 6.61e-12 |
| ribonucleoside triphosphate metabolism | The chemical reactions and physical changes involving a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety. | 57 | 4.43 | 23 | 5.19 | 1.18e-11 |
| nucleoside triphosphate metabolism | The chemical reactions and physical changes involving a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety. | 62 | 4.82 | 24 | 4.98 | 1.23e-11 |
| nucleoside phosphate metabolism | 41 | 3.19 | 19 | 5.96 | 3.82e-11 | |
| ATP metabolism | The chemical reactions and physical changes involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. | 47 | 3.66 | 20 | 5.47 | 8.06e-11 |
| energy derivation by oxidation of organic compounds | 177 | 13.77 | 41 | 2.98 | 2.16e-10 | |
| main pathways of carbohydrate metabolism | 118 | 9.18 | 32 | 3.49 | 2.85e-10 | |
| group transfer coenzyme metabolism | 51 | 3.97 | 20 | 5.04 | 4.71e-10 | |
| ATP synthesis coupled proton transport | The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. | 38 | 2.96 | 17 | 5.75 | 8.11e-10 |
| proton transport | The directed movement of protons (hydrogen ions) into, out of, within or between cells. | 74 | 5.76 | 24 | 4.17 | 8.81e-10 |
| transport | The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. | 1743 | 135.56 | 208 | 1.53 | 8.90e-10 |
| hydrogen transport | The directed movement of hydrogen (H2 or H+), into, out of, within or between cells. | 75 | 5.83 | 24 | 4.11 | 1.20e-09 |
| purine nucleotide biosynthesis | The formation from simpler components of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. | 83 | 6.46 | 25 | 3.87 | 2.26e-09 |
| regulation of neurotransmitter levels | Any process that modulates levels of neurotransmitter. | 66 | 5.13 | 22 | 4.29 | 2.44e-09 |
| ribonucleotide biosynthesis | The formation from simpler components of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. | 87 | 6.77 | 25 | 3.69 | 6.64e-09 |
| coenzyme biosynthesis | The formation from simpler components of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. | 64 | 4.98 | 21 | 4.22 | 7.70e-09 |
| purine nucleotide metabolism | The chemical reactions and physical changes involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. | 88 | 6.84 | 25 | 3.65 | 8.59e-09 |
| coenzyme and prosthetic group biosynthesis | The formation from simpler components of coenzymes and prosthetic groups. | 82 | 6.38 | 24 | 3.76 | 8.85e-09 |
| tricarboxylic acid cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two C02 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. | 39 | 3.03 | 16 | 5.28 | 1.18e-08 |
| ATP synthesis coupled electron transport (sensu Eukarya) | The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane of eukaryotes. | 30 | 2.33 | 14 | 6.00 | 1.29e-08 |
| mitochondrial electron transport, NADH to ubiquinone | The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. | 26 | 2.02 | 13 | 6.43 | 1.50e-08 |
| purine ribonucleotide biosynthesis | The formation from simpler components of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. | 79 | 6.14 | 23 | 3.74 | 2.00e-08 |
| neurotransmitter secretion | The regulated release of neurotransmitter into the synaptic cleft. | 36 | 2.80 | 15 | 5.36 | 2.63e-08 |
| ribonucleotide metabolism | The chemical reactions and physical changes involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. | 94 | 7.31 | 25 | 3.42 | 3.67e-08 |
| nucleotide biosynthesis | The formation from simpler components of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). | 135 | 10.50 | 31 | 2.95 | 3.96e-08 |
| coenzyme metabolism | The chemical reactions and physical changes involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. | 109 | 8.48 | 27 | 3.18 | 5.44e-08 |
| purine ribonucleotide metabolism | The chemical reactions and physical changes involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. | 84 | 6.53 | 23 | 3.52 | 7.07e-08 |
| transmission of nerve impulse | The sequential, electrochemical polarization and depolarisation that travels across the membrane of a nerve cell (neuron) in response to stimulation. | 312 | 24.27 | 53 | 2.18 | 7.10e-08 |
| intracellular transport | The directed movement of substances within a cell. | 562 | 43.71 | 81 | 1.85 | 7.38e-08 |
| synaptic transmission | The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. | 306 | 23.80 | 52 | 2.19 | 9.25e-08 |
| coenzyme and prosthetic group metabolism | The chemical reactions and physical changes involving coenzymes and prosthetic groups. | 133 | 10.34 | 30 | 2.90 | 9.92e-08 |
| protein folding | 145 | 11.28 | 31 | 2.75 | 2.21e-07 | |
| carbohydrate metabolism | The chemical reactions and physical changes involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. | 375 | 29.16 | 58 | 1.99 | 4.79e-07 |
| electron transport | The transport of electrons from an electron donor to an electron acceptor. | 285 | 22.17 | 47 | 2.12 | 8.92e-07 |
| nucleotide metabolism | The chemical reactions and physical changes involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). | 187 | 14.54 | 35 | 2.41 | 1.11e-06 |
| ubiquitin-dependent protein catabolism | Destruction of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. | 126 | 9.80 | 27 | 2.76 | 1.23e-06 |
| monovalent inorganic cation transport | The directed movement of inorganic cations with a valency of one into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. | 264 | 20.53 | 44 | 2.14 | 1.46e-06 |
| secretory pathway | The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane. | 115 | 8.94 | 25 | 2.80 | 2.27e-06 |
| aerobic respiration | The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. | 14 | 1.09 | 8 | 7.35 | 2.62e-06 |
| secretion | The regulated release of a substance by a cell or group of cells. | 83 | 6.46 | 20 | 3.10 | 4.34e-06 |
| synaptic vesicle transport | Transport of vesicles containing neurotransmitters back and forth across the synapse. | 24 | 1.87 | 10 | 5.36 | 5.71e-06 |
| vesicle-mediated transport | The transport of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. | 361 | 28.08 | 53 | 1.89 | 6.82e-06 |
| glycolysis | The breakdown of a monosaccharide (generally glucose) into simpler components, including pyruvate. | 59 | 4.59 | 16 | 3.49 | 7.65e-06 |
| post-Golgi transport | The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane. | 21 | 1.63 | 9 | 5.51 | 1.29e-05 |
| phosphate metabolism | The chemical reactions and physical changes involving the phosphate group, the anion or salt of any phosphoric acid. | 825 | 64.16 | 99 | 1.54 | 1.45e-05 |
| protein transport | The directed movement of proteins into, out of, within or between cells. | 449 | 34.92 | 61 | 1.75 | 1.74e-05 |
| organismal movement | Physiological processes involved in the relocation of an organism or an anatomical part of an organism. | 484 | 37.64 | 64 | 1.70 | 2.57e-05 |
| amino acid catabolism | The breakdown into simpler components of amino acids, organic acids containing one or more amino substituents. | 52 | 4.04 | 14 | 3.46 | 3.05e-05 |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. | 422 | 32.82 | 57 | 1.74 | 3.77e-05 |
| glucose catabolism | The breakdown into simpler components of glucose, the aldohexose gluco-hexose. | 68 | 5.29 | 16 | 3.03 | 5.22e-05 |
| microtubule-based process | Any cellular process that depends upon or alters the microtubule cytoskeleton (that part of the cytoskeleton comprising microtubules and their associated proteins). | 113 | 8.79 | 22 | 2.50 | 5.45e-05 |
| amine catabolism | The breakdown into simpler components of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. | 55 | 4.28 | 14 | 3.27 | 6.02e-05 |
| cytoskeleton-dependent intracellular transport | The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell. | 31 | 2.41 | 10 | 4.15 | 7.78e-05 |
| exocytosis | The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. | 37 | 2.88 | 11 | 3.82 | 7.98e-05 |
| TCA intermediate metabolism | The chemical reactions and physical changes involving intermediates of the tricarboxylic acid cycle. | 27 | 2.10 | 9 | 4.29 | 1.33e-04 |
| cation transport | The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells. | 423 | 32.90 | 55 | 1.67 | 1.40e-04 |
| carbohydrate catabolism | The breakdown into simpler components of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. | 91 | 7.08 | 18 | 2.54 | 2.03e-04 |
| synaptic vesicle exocytosis | Exocytosis of a synaptic vesicle from the presynaptic membrane. | 9 | 0.70 | 5 | 7.14 | 2.74e-04 |
| phosphorylation | The process of introducing a phosphoric group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. | 682 | 53.04 | 79 | 1.49 | 2.96e-04 |
| hexose catabolism | The breakdown into simpler components of hexose, any aldose with a chain of six carbon atoms in the molecule. | 79 | 6.14 | 16 | 2.60 | 3.38e-04 |
| glucose metabolism | The chemical reactions and physical changes involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. | 96 | 7.47 | 18 | 2.41 | 4.04e-04 |
| neuron differentiation | The process whereby a relatively unspecialized cell acquires specialized features of a neuron. | 10 | 0.78 | 5 | 6.43 | 5.14e-04 |
| positive regulation of adenylate cyclase activity | Any process that activates or increases the rate of adenylate cyclase activity. | 33 | 2.57 | 9 | 3.51 | 7.16e-04 |
| protein metabolism | The chemical reactions and physical changes involving a specific protein, rather than of proteins in general. Includes protein modification. | 2314 | 179.97 | 222 | 1.23 | 8.72e-04 |
| axon cargo transport | The directed movement of organelles along microtubules in nerve cell axons. | 11 | 0.86 | 5 | 5.84 | 8.81e-04 |
| regulation of adenylate cyclase activity | Any process that modulates the frequency, rate or extent of adenylate cyclase activity. | 55 | 4.28 | 12 | 2.81 | 9.06e-04 |
| neurophysiological process | The processes pertaining to the functions of the nervous system of an organism. | 650 | 50.55 | 73 | 1.44 | 1.13e-03 |
| G-protein signaling, adenylate cyclase activating pathway | 35 | 2.72 | 9 | 3.31 | 1.14e-03 | |
| ion transport | The directed movement of charged atoms or small charged molecules into, out of, within or between cells. | 651 | 50.63 | 73 | 1.44 | 1.18e-03 |
| biosynthesis | The energy-requiring part of metabolism in which simpler substances are transformed into more complex ones, as in growth and other biosynthetic processes. | 1001 | 77.85 | 104 | 1.34 | 1.81e-03 |
| regulation of enzyme activity | Any process that modulates the activity of an enzyme. | 118 | 9.18 | 19 | 2.07 | 1.92e-03 |
| organelle organization and biogenesis | The assembly and arrangement of any organelle within a cell. | 383 | 29.79 | 46 | 1.54 | 2.37e-03 |
| cytoskeleton organization and biogenesis | The assembly and arrangement of cytoskeletal structures. | 314 | 24.42 | 39 | 1.60 | 2.70e-03 |
| regulation of actin polymerization and/or depolymerization | Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. | 14 | 1.09 | 5 | 4.59 | 3.13e-03 |
| regulation of actin filament polymerization | Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. | 9 | 0.70 | 4 | 5.71 | 3.35e-03 |
| carboxylic acid metabolism | The chemical reactions and physical changes involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). | 394 | 30.64 | 46 | 1.50 | 4.07e-03 |
| mitochondrion organization and biogenesis | The assembly and arrangement of a mitochondrion. | 5 | 0.39 | 3 | 7.71 | 4.17e-03 |
| mitochondrial transport | Transport of substances into, out of or within a mitochondrion. | 21 | 1.63 | 6 | 3.67 | 4.32e-03 |
| organic acid metabolism | The chemical reactions and physical changes involving organic acids, any acidic compound containing carbon in covalent linkage. | 396 | 30.80 | 46 | 1.49 | 4.47e-03 |
| macromolecule biosynthesis | The formation from simpler components of macromolecules, large molecules including proteins, nucleic acids and carbohydrates. | 845 | 65.72 | 87 | 1.32 | 5.05e-03 |
| ubiquitin cycle | The cyclical process by which one or more ubiquitin moieties are added to (ubiquitination) and removed from (deubiquitination) a protein. | 69 | 5.37 | 12 | 2.24 | 6.62e-03 |
| biological_process | A phenomenon marked by changes that lead to a particular result, mediated by one or more gene products. | 10151 | 789.47 | 857 | 1.09 | 6.98e-03 |
| oxygen transport | The directed movement of oxygen (O2) into, out of, within or between cells. | 11 | 0.86 | 4 | 4.68 | 7.73e-03 |
| catabolism | Any metabolic process involving the breakdown of complex substances into smaller products, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. | 826 | 64.24 | 84 | 1.31 | 7.81e-03 |
| neurogenesis | The origin and formation of neurons. | 484 | 37.64 | 53 | 1.41 | 7.90e-03 |
| regulation of actin filament length | Any process that controls the length of actin filaments in a cell. | 17 | 1.32 | 5 | 3.78 | 7.95e-03 |
| cytoplasm organization and biogenesis | The assembly and arrangement of the cytoplasm and its components. | 434 | 33.75 | 48 | 1.42 | 9.23e-03 |
| metabolism | The totality of the chemical reactions and physical changes that occur in living organisms, comprising anabolism and catabolism; may be qualified to mean the chemical reactions and physical processes undergone by a particular substance, or class of substances, in a living organism. | 5871 | 456.61 | 506 | 1.11 | 9.33e-03 |
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