#alzheimers_dn
#
#list name	reference	description	total probes	expected	actual	enrichment	bin prob
neurotransmitter transport	GO:0006836	The directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.	30	2.33318890814558	2	0.85719591457753	0.688897044385815
nucleobase, nucleoside, nucleotide and nucleic acid transport	GO:0015931	The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells.	59	4.58860485268631	3	0.653793494169303	0.847185625667374
nucleic acid transport	GO:0050657	The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of, within or between cells.	51	3.96642114384749	2	0.504232890927959	0.914674019976109
RNA transport	GO:0050658	The directed movement of RNA, ribonucleic acids, into, out of, within or between cells.	51	3.96642114384749	2	0.504232890927959	0.914674019976109
mRNA transport	GO:0051028	The directed movement of mRNA, messenger ribonucleic acid, into, out of, within or between cells.	41	3.18869150779896	1	0.313608261430804	0.963829721624951
organic acid transport	GO:0015849	The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells.	63	4.89969670710572	4	0.81637706150241	0.731820433824273
carboxylic acid transport	GO:0046942	The directed movement of carboxylic acids into, out of, within or between cells. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).	63	4.89969670710572	4	0.81637706150241	0.731820433824273
peptide transport	GO:0015833	The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells.	14	1.08882149046794	0	0	1
oligopeptide transport	GO:0006857	The directed movement of oligopeptides into, out of, within or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.	10	0.777729636048527	0	0	1
protein transport	GO:0015031	The directed movement of proteins into, out of, within or between cells.	449	34.9200606585789	61	1.74684690832615	1.74054518234865e-05
regulation of transport	GO:0051049	Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.	25	1.94432409012132	5	2.57158774373259	0.0407143277020134
negative regulation of transport	GO:0051051	Any process that stops, prevents or reduces the rate of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.	7	0.544410745233969	0	0	1
positive regulation of transport	GO:0051050	Any process that activates or increases the rate of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.	5	0.388864818024263	0	0	1
regulation of endocytosis	GO:0030100	Any process that modulates the frequency, rate or extent of endocytosis.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
secretory pathway	GO:0045045	The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane.	115	8.94389081455806	25	2.79520406927456	2.27165298958874e-06
exocytosis	GO:0006887	The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells.	37	2.87759965337955	11	3.82263042987277	7.98444993848315e-05
vesicle docking during exocytosis	GO:0006904	Initial attachment of a transport vesicle membrane with the target membrane during the process of exocytosis.	9	0.699956672443674	2	2.85731971525843	0.151204954623315
vesicle targeting	GO:0006903	Targeting of a vesicle to a specific destination membrane.	8	0.622183708838821	0	0	1
vesicle-mediated transport	GO:0016192	The transport of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.	361	28.0760398613518	53	1.88773061520536	6.82385803513746e-06
endocytosis	GO:0006897	The uptake of external materials by cells by the invagination of small region of the plasma membrane to form a new intracellular membrane-limited vesicle.	179	13.9213604852686	19	1.36480913773517	0.104084737176985
phagocytosis	GO:0006909	The process whereby phagocytes engulf external particulate material by extension and fusion of pseudopods around each particle. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.	24	1.86655112651646	2	1.07149489322191	0.566803918253758
receptor mediated endocytosis	GO:0006898	The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.	39	3.03314558058925	1	0.329690736375973	0.957471883285156
vesicle docking	GO:0048278	Initial attachment of a transport vesicle membrane with the target membrane.	9	0.699956672443674	2	2.85731971525843	0.151204954623315
vitamin/cofactor transport	GO:0015875	The directed movement of vitamins and cofactors into, out of, within or between cells.	12	0.933275563258232	0	0	1
cell motility	GO:0006928	Any process involved in the controlled movement of a cell.	391	30.4092287694974	35	1.15096638146599	0.216678106756188
cell migration	GO:0016477	The orderly movement of cells from one site to another, often during the development of a multicellular organism.	83	6.45515597920277	9	1.39423431889116	0.195589200349868
axon guidance	GO:0007411		38	2.9553726169844	5	1.69183404192934	0.170068093739003
immune cell migration	GO:0050900	The movement of immune cells (leukocytes) within or between different tissues and organs of the body.	12	0.933275563258232	0	0	1
immune cell chemotaxis	GO:0030595	The movement of an immune cell in response to an external stimulus.	12	0.933275563258232	0	0	1
neutrophil chemotaxis	GO:0030593	The movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.	6	0.466637781629116	0	0	1
regulation of cell migration	GO:0030334	Any process that modulates the frequency, rate or extent of cell migration.	11	0.855502599653379	0	0	1
substrate-bound cell migration	GO:0006929		6	0.466637781629116	0	0	1
muscle contraction	GO:0006936	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	184	14.3102253032929	9	0.628920915586775	0.953300757505363
regulation of muscle contraction	GO:0006937	Any process that modulates the frequency, rate or extent of muscle contraction.	32	2.48873483535529	2	0.803621169916435	0.722763622359169
regulation of smooth muscle contraction	GO:0006940	Any process that modulates the frequency, rate or extent of smooth muscle contraction.	8	0.622183708838821	0	0	1
regulation of striated muscle contraction	GO:0006942	Any process that modulates the frequency, rate or extent of striated muscle contraction.	7	0.544410745233969	0	0	1
smooth muscle contraction	GO:0006939	A process leading to shortening and/or development of tension in smooth muscle tissue.	27	2.09987001733102	0	0	1
striated muscle contraction	GO:0006941	A process leading to shortening and/or development of tension in striated muscle tissue.	39	3.03314558058925	0	0	1
sperm motility	GO:0030317	Any process involved in the controlled movement of a sperm cell.	6	0.466637781629116	1	2.14298978644383	0.384784738770702
cellular defense response	GO:0006968	A defense response that is mediated by cells.	102	7.93284228769497	4	0.504232890927959	0.961339646317892
cellular defense response (sensu Vertebrata)	GO:0016066	A defense response that is mediated by cells, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742).	19	1.4776863084922	0	0	1
cell-mediated immune response	GO:0042087	A defense response that is mediated by cells rather than antibody or other humoral factors.	19	1.4776863084922	0	0	1
T-helper 1 type immune response	GO:0042088		18	1.39991334488735	0	0	1
interferon-gamma biosynthesis	GO:0042095	The formation from simpler components of interferon-gamma.	7	0.544410745233969	0	0	1
regulation of interferon-gamma biosynthesis	GO:0045072	Any process that modulates the frequency, rate or extent of the formation from simpler components of interferon-gamma.	6	0.466637781629116	0	0	1
interleukin-2 biosynthesis	GO:0042094	The formation from simpler components of interleukin-2.	9	0.699956672443674	0	0	1
regulation of interleukin-2 biosynthesis	GO:0045076	Any process that modulates the frequency, rate or extent of the formation from simpler components of interleukin-2.	8	0.622183708838821	0	0	1
extracellular matrix organization and biogenesis	GO:0030198	The assembly and arrangement of an extracellular matrix.	39	3.03314558058925	2	0.659381472751946	0.817599634724074
synapse organization and biogenesis	GO:0050808	The assembly and arrangement of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).	25	1.94432409012132	2	1.02863509749304	0.589353531066977
synaptogenesis	GO:0007416	The formation of a synapse.	25	1.94432409012132	2	1.02863509749304	0.589353531066977
regulation of synaptic plasticity	GO:0048167	A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.	14	1.08882149046794	1	0.918424194190211	0.678093385646598
membrane fusion	GO:0006944	The joining of two lipid bilayers to form a single membrane.	25	1.94432409012132	2	1.02863509749304	0.589353531066977
regulation of cellular process	GO:0050794	Any process that modulates the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.	899	69.9178942807626	54	0.772334472533703	0.982478106682493
development	GO:0007275	Biological processes specifically aimed at the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).	1971	153.290511265165	118	0.769780197261405	0.999087445514967
aging	GO:0007568	The inherent decline over time, from the optimal fertility and viability of early maturity, that culminates in death and may be preceded by other indications, such as sterility.	9	0.699956672443674	0	0	1
embryonic development	GO:0009790	The development of an organism from zygote formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific and may be somewhat arbitrary. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.	65	5.05524263431542	8	1.58251553460467	0.130660505370158
embryonic development (sensu Animalia)	GO:0009792	The embryonic development of an animal from zygote formation until the end of its embryonic life stage. The end of the embryonic life stage is organism specific and may be somewhat arbitrary; for mammals it is usually considered to be birth; for insects the hatching of the first instar larva from the eggshell.	29	2.25541594454073	4	1.7735087887811	0.185356447409555
embryonic development (sensu Vertebrata)	GO:0043009	The embryonic development of an organism from zygote formation until birth, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742).	18	1.39991334488735	3	2.14298978644383	0.160314266774028
embryonic development (sensu Mammalia)	GO:0001701	The embryonic development which ends at birth, as in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674).	18	1.39991334488735	3	2.14298978644383	0.160314266774028
eye morphogenesis (sensu Mammalia)	GO:0001747	The formation and development of the eye, as in, but not restricted to, mammals (Mammalia, ncbi_taxonomy_id:40674).	9	0.699956672443674	0	0	1
gastrulation	GO:0007369	A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.	10	0.777729636048527	1	1.2857938718663	0.554981054514678
formation of primary germ layer	GO:0001704	The formation of the ectoderm, mesoderm and endoderm during gastrulation.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
mesoderm formation	GO:0001707	Biological processes that contribute to the act of giving rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
embryonic morphogenesis	GO:0009795	The developmental processes by which defined structures within an embryo are generated.	14	1.08882149046794	0	0	1
embryonic appendage morphogenesis	GO:0035113	The stages of appendage morphogenesis that occur in the embryo. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch.	4	0.311091854419411	0	0	1
embryonic limb morphogenesis	GO:0030326	The stages of limb morphogenesis that take place in the embryo. A limb is an appendage of an animal used for locomotion or grasping.	4	0.311091854419411	0	0	1
embryonic eye morphogenesis	GO:0048048	The stages of eye morphogenesis that take place in the embryo phase, and that are involved in forming the post-embryonic eye.	9	0.699956672443674	0	0	1
embryonic pattern specification	GO:0009880	The processes that result in the patterns of cell differentiation that will arise in an embryo.	5	0.388864818024263	0	0	1
growth	GO:0040007	The increase in size or mass of an entire organism (as used in GO), as opposed to cell growth (GO:0016049).	154	11.9770363951473	9	0.751437977064718	0.853970120928037
regulation of growth	GO:0040008	Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.	89	6.92179376083189	5	0.722356107790054	0.830790390897428
negative regulation of growth	GO:0045926	Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.	29	2.25541594454073	2	0.886754394390549	0.670720342034218
positive regulation of growth	GO:0045927	Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.	4	0.311091854419411	0	0	1
mesoderm development	GO:0007498	Biological processes specifically aimed at the progression of the mesoderm over time, from its initial formation to a mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.	43	3.34423743500867	4	1.19608732266632	0.432430293669227
mesoderm morphogenesis	GO:0048332	Developmental processes by which the mesoderm is generated and organized. Morphogenesis pertains to the creation of form.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
morphogenesis	GO:0009653	Developmental processes by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.	1362	105.926776429809	88	0.830762560383509	0.971488365184472
appendage morphogenesis	GO:0035107	Generation and organization of the structure of an appendage, an organ or part that is attached to the trunk of an organism. For example a limb or a branch.	4	0.311091854419411	0	0	1
limb morphogenesis	GO:0035108	Generation and organization of the structure of a limb, an appendage of an animal used for locomotion or grasping. For example a leg, arm or some types of fin.	4	0.311091854419411	0	0	1
organogenesis	GO:0009887	Morphogenesis of a tissue or tissues that function together to perform a specific function. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.	1129	87.8056759098787	77	0.876936475940697	0.897320053319758
blood vessel development	GO:0001568	Development of vasculature carrying blood.	57	4.4330589254766	2	0.45115574451449	0.942495442230529
angiogenesis	GO:0001525	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.	57	4.4330589254766	2	0.45115574451449	0.942495442230529
regulation of angiogenesis	GO:0045765	Any process that modulates the frequency, rate or extent of angiogenesis.	19	1.4776863084922	0	0	1
negative regulation of angiogenesis	GO:0016525	Any process that stops, prevents or reduces the rate of angiogenesis.	14	1.08882149046794	0	0	1
eye morphogenesis	GO:0001654	Formation and development of the eye, the organ of sight.	12	0.933275563258232	0	0	1
eye morphogenesis (sensu Vertebrata)	GO:0043010	The formation and development of the eye, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742).	9	0.699956672443674	0	0	1
gonad development	GO:0008406	The development of an animal organ that produces gametes; in some species it also produces hormones.	21	1.63323223570191	1	0.612282796126807	0.817360440672319
female gonad development	GO:0008585		6	0.466637781629116	0	0	1
male gonad development	GO:0008584		8	0.622183708838821	0	0	1
heart development	GO:0007507	Development of the heart; a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.	26	2.02209705372617	1	0.49453610456396	0.878161624233234
hemopoiesis	GO:0030097	The process of blood cell formation. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.	83	6.45515597920277	2	0.309829848642481	0.990348250673568
histogenesis	GO:0009888	The origin and formation of tissues.	142	11.0437608318891	7	0.633842049511554	0.931135067821102
ectoderm development	GO:0007398	Biological processes specifically aimed at the progression of the ectoderm over time, from its initial formation to a mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.	96	7.46620450606586	3	0.401810584958217	0.982511536544288
epidermis development	GO:0008544	Biological processes specifically aimed at the progression of the epidermis over time, from its initial formation to a mature structure.	79	6.14406412478336	3	0.488276153873277	0.950671632332662
muscle development	GO:0007517	Development of an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.	165	12.8325389948007	9	0.70134211192707	0.901665608306967
myogenesis	GO:0007519	The developmental sequence of events leading to the formation of adult muscle that occurs in the animal and in cultured cells. In vertebrate skeletal muscle the main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.	21	1.63323223570191	2	1.22456559225361	0.493912087895391
regulation of myogenesis	GO:0016202	Any process that modulates the frequency, rate or extent of myogenesis.	3	0.233318890814558	0	0	1
neurogenesis	GO:0007399	The origin and formation of neurons.	484	37.6421143847487	53	1.40799742167177	0.00790431740891805
axonogenesis	GO:0007409	Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells.	54	4.19974003466205	5	1.19054988135768	0.411625000318262
central nervous system development	GO:0007417	Formation and development of the central nervous system; the core nervous system, which consists of the brain, spinal cord, and spinal nerves.	103	8.01061525129983	14	1.74768099088623	0.0286886943409812
brain development	GO:0007420	Formation and development of the brain; one of the two components of the central nervous system, the brain is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).	30	2.33318890814558	3	1.2857938718663	0.416246509111854
peripheral nervous system development	GO:0007422		22	1.71100519930676	2	1.16890351987845	0.51906762486396
sensory organ development	GO:0007423		9	0.699956672443674	0	0	1
regulation of neurogenesis	GO:0050767	Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons.	16	1.24436741767764	1	0.803621169916435	0.726217553201261
odontogenesis	GO:0042476	Formation and development of a tooth or teeth.	7	0.544410745233969	0	0	1
skeletal development	GO:0001501	Development of the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).	157	12.2103552859619	7	0.573283891914909	0.964750132539883
cartilage condensation	GO:0001502		14	1.08882149046794	0	0	1
ossification	GO:0001503	The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.	28	2.17764298093588	2	0.918424194190211	0.65169040816838
bone mineralization	GO:0030282	The deposition of calcium phosphate in bone tissue.	10	0.777729636048527	0	0	1
regulation of bone mineralization	GO:0030500	Any process that modulates the frequency, rate or extent of bone mineralization.	6	0.466637781629116	0	0	1
regulation of ossification	GO:0030278	Any process that modulates the frequency, rate or extent of bone formation.	6	0.466637781629116	0	0	1
pattern specification	GO:0007389	The processes that result in the patterns of cell differentiation that will arise in an organism.	40	3.11091854419411	0	0	1
axis specification	GO:0009798	The establishment, maintenance and elaboration of a pattern around a line or a set of lines.	5	0.388864818024263	0	0	1
pigmentation	GO:0048066	The deposition of coloring matter in an organ or organism.	34	2.64428076256499	3	1.13452400458791	0.499107478166499
eye pigmentation	GO:0048069	Establishment of a pattern of pigment in the eye of an organism.	6	0.466637781629116	0	0	1
pigment metabolism	GO:0042440	The chemical reactions and physical changes involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.	32	2.48873483535529	3	1.20543175487465	0.458355693535576
heme metabolism	GO:0042168	The chemical reactions and physical changes involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.	22	1.71100519930676	2	1.16890351987845	0.51906762486396
heme biosynthesis	GO:0006783	The formation from simpler components of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.	17	1.3221403812825	2	1.51269867278388	0.385531596872848
melanin metabolism	GO:0006582	The chemical reactions and physical changes involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
melanin biosynthesis	GO:0042438	The formation from simpler components of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
melanin biosynthesis from tyrosine	GO:0006583	The formation of melanin from simpler components, including tyrosine.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
pigment biosynthesis	GO:0046148	The formation from simpler components of a pigment, any general or particular coloring matter in living organisms, e.g. melanin.	27	2.09987001733102	3	1.42865985762922	0.351306942612832
post-embryonic development	GO:0009791	The development of an organism after the completion of embryonic development. See embryonic development.	7	0.544410745233969	0	0	1
regulation of development	GO:0050793	Any process that modulates the frequency, rate or extent of development, the biological processes specifically aimed at the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).	127	9.87716637781629	7	0.708705283705832	0.872147809407672
regulation of gene expression, epigenetic	GO:0040029	Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.	34	2.64428076256499	2	0.756349336391938	0.753457253912228
DNA methylation	GO:0006306	The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.	11	0.855502599653379	1	1.16890351987845	0.589591496765378
negative regulation of gene expression, epigenetic	GO:0045814	Any epigenetic process that stops, prevents or reduces the rate of gene expression.	12	0.933275563258232	1	1.07149489322191	0.621510182350567
reproduction	GO:0000003	The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism.	163	12.676993067591	7	0.552181417365894	0.973369487787274
sexual reproduction	GO:0019953	The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.	163	12.676993067591	7	0.552181417365894	0.973369487787274
fertilization	GO:0009566	The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).	24	1.86655112651646	1	0.535747446610956	0.856745457935699
fertilization (sensu Animalia)	GO:0007338	The union of male and female gametes to form a zygote.	24	1.86655112651646	1	0.535747446610956	0.856745457935699
gametogenesis	GO:0007276	The generation, maintenance, and proliferation of gametes.	142	11.0437608318891	6	0.543293185295618	0.968532083350168
female gamete generation	GO:0007292	The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell.	16	1.24436741767764	1	0.803621169916435	0.726217553201261
male gamete generation	GO:0048232	Generation of the male gamete; specialised haploid cells produced by meiosis and involved in sexual reproduction.	116	9.02166377816291	5	0.554221496494093	0.952260479886928
spermatogenesis	GO:0007283	The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.	116	9.02166377816291	5	0.554221496494093	0.952260479886928
sex determination	GO:0007530	Any process that establishes and transmits the specification of sexual status of an individual organism.	12	0.933275563258232	1	1.07149489322191	0.621510182350567
sex differentiation	GO:0007548	The establishment of the sex of an organism by physical differentiation.	16	1.24436741767764	2	1.60724233983287	0.356800974762934
obsolete biological process	GO:0008371	These are terms that have been removed from the active process ontology.	333	25.8983968804159	21	0.810861000276042	0.867145888142243
embryogenesis and morphogenesis	GO:0007345	OBSOLETE. Formation and development of an embryo and its organized structures.	84	6.53292894280762	3	0.459212097095106	0.963419081888637
glutathione conjugation reaction	GO:0006803	OBSOLETE (was not defined before being made obsolete).	10	0.777729636048527	1	1.2857938718663	0.554981054514678
histogenesis and organogenesis	GO:0007397	OBSOLETE. The generation of organized tissues or of whole organs.	67	5.21078856152513	3	0.575728599343117	0.901397244732094
invasive growth	GO:0007125	OBSOLETE (was not defined before being made obsolete).	23	1.78877816291161	0	0	1
mitochondrial translocation	GO:0006628	OBSOLETE. The translocation of proteins across the mitochondrial membrane. In the presence of a translocating chain, the outer membrane import machinery (MOM complex) and the inner membrane import machinery (MIM complex) form translocation contact sites as a part of the membrane preprotein import machinery.	15	1.16659445407279	1	0.85719591457753	0.703129017048866
mRNA splicing	GO:0006371	OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced.	60	4.66637781629116	4	0.85719591457753	0.695743391678724
peroxidase reaction	GO:0006804	OBSOLETE (was not defined before being made obsolete).	5	0.388864818024263	0	0	1
phosphatidylinositol-4,5-bisphosphate hydrolysis	GO:0007203	OBSOLETE (was not defined before being made obsolete).	9	0.699956672443674	0	0	1
regulation of synapse	GO:0007273	OBSOLETE (was not defined before being made obsolete).	9	0.699956672443674	3	4.28597957288765	0.0276600757776216
taste perception	GO:0007607	OBSOLETE. The series of events required for the chemical composition of a soluble stimulus to be received and converted to a molecular signal.	6	0.466637781629116	2	4.28597957288765	0.0734918863657436
viral replication	GO:0008166	OBSOLETE (was not defined before being made obsolete).	9	0.699956672443674	0	0	1
physiological process	GO:0007582	Those processes specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms.	8910	692.957105719237	752	1.08520425549209	0.0109396574611239
coagulation	GO:0050817	The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.	127	9.87716637781629	6	0.607461671747856	0.935796599729277
blood coagulation	GO:0007596	The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.	123	9.56607452339688	5	0.522680435718006	0.966619105682772
platelet activation	GO:0030168	A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.	19	1.4776863084922	1	0.676733616771734	0.785256933460783
regulation of blood coagulation	GO:0030193	Any process that modulates the frequency, rate or extent of blood coagulation.	11	0.855502599653379	0	0	1
negative regulation of blood coagulation	GO:0030195	Any process that stops, prevents or reduces the rate of blood coagulation.	11	0.855502599653379	0	0	1
regulation of coagulation	GO:0050818	Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.	17	1.3221403812825	1	0.756349336391938	0.747510425471787
negative regulation of coagulation	GO:0050819	Any process that stops, prevents or reduces the rate of coagulation.	17	1.3221403812825	1	0.756349336391938	0.747510425471787
death	GO:0016265	A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism (see 'apoptosis ; GO:0006915').	530	41.2196707105719	30	0.72780785199979	0.975630530162371
extracellular structure organization and biogenesis	GO:0043062	The assembly and arrangement of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.	39	3.03314558058925	2	0.659381472751946	0.817599634724074
homeostasis	GO:0042592	Any of the processes involved in the maintenance of an internal equilibrium within an organism or cell.	106	8.24393414211438	6	0.72780785199979	0.840932201962416
ion homeostasis	GO:0050801	Any of the processes involved in the maintenance of an internal equilibrium of ions within an organism or cell.	84	6.53292894280762	6	0.918424194190211	0.644721637539678
metabolism	GO:0008152	The totality of the chemical reactions and physical changes that occur in living organisms, comprising anabolism and catabolism; may be qualified to mean the chemical reactions and physical processes undergone by a particular substance, or class of substances, in a living organism.	5871	456.60506932409	506	1.10817867341909	0.00933152272130773
alcohol metabolism	GO:0006066	The chemical reactions and physical changes involving alcohols, any of a class of alkyl compounds containing a hydroxyl group.	253	19.6765597920277	26	1.32136919638434	0.0895554470248488
alcohol biosynthesis	GO:0046165	The formation from simpler components of alcohols, any of a class of alkyl compounds containing a hydroxyl group.	22	1.71100519930676	3	1.75335527981768	0.242356718209695
monosaccharide biosynthesis	GO:0046364	The formation from simpler components of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms.	22	1.71100519930676	3	1.75335527981768	0.242356718209695
hexose biosynthesis	GO:0019319	The formation from simpler components of hexose, any aldose with a chain of six carbon atoms in the molecule.	22	1.71100519930676	3	1.75335527981768	0.242356718209695
gluconeogenesis	GO:0006094	The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.	16	1.24436741767764	3	2.4108635097493	0.123149544778158
alcohol catabolism	GO:0046164	The breakdown into simpler components of alcohols, any of a class of alkyl compounds containing a hydroxyl group.	79	6.14406412478336	16	2.60413948732414	0.000338045021054901
monosaccharide catabolism	GO:0046365	The breakdown into simpler components of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms.	79	6.14406412478336	16	2.60413948732414	0.000338045021054901
hexose catabolism	GO:0019320	The breakdown into simpler components of hexose, any aldose with a chain of six carbon atoms in the molecule.	79	6.14406412478336	16	2.60413948732414	0.000338045021054901
fucose catabolism	GO:0019317	The breakdown into simpler components of fucose (6-deoxygalactose).	11	0.855502599653379	0	0	1
L-fucose catabolism	GO:0042355	The breakdown into simpler components of L-fucose (6-deoxy-Lgalactose).	11	0.855502599653379	0	0	1
glucose catabolism	GO:0006007	The breakdown into simpler components of glucose, the aldohexose gluco-hexose.	68	5.28856152512998	16	3.02539734556775	5.22479900397192e-05
glycolysis	GO:0006096	The breakdown of a monosaccharide (generally glucose) into simpler components, including pyruvate.	59	4.58860485268631	16	3.48689863556961	7.64616108601509e-06
pentose-phosphate shunt	GO:0006098	The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses.	10	0.777729636048527	2	2.57158774373259	0.17968906149323
ethanol metabolism	GO:0006067	The chemical reactions and physical changes involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.	8	0.622183708838821	1	1.60724233983287	0.476757755147065
ethanol oxidation	GO:0006069		8	0.622183708838821	1	1.60724233983287	0.476757755147065
monosaccharide metabolism	GO:0005996	The chemical reactions and physical changes involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.	132	10.2660311958406	18	1.75335527981768	0.0140942034125745
hexose metabolism	GO:0019318	The chemical reactions and physical changes involving a hexose, any aldose with a chain of six carbon atoms in the molecule.	132	10.2660311958406	18	1.75335527981768	0.0140942034125745
fructose metabolism	GO:0006000	The chemical reactions and physical changes involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.	20	1.55545927209705	1	0.642896935933148	0.801958138159132
fucose metabolism	GO:0006004	The chemical reactions and physical changes involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose.	18	1.39991334488735	0	0	1
L-fucose metabolism	GO:0042354	The chemical reactions and physical changes involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants.	15	1.16659445407279	0	0	1
galactose metabolism	GO:0006012	The chemical reactions and physical changes involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.	7	0.544410745233969	0	0	1
glucose metabolism	GO:0006006	The chemical reactions and physical changes involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.	96	7.46620450606586	18	2.4108635097493	0.000403844594175111
phenol metabolism	GO:0018958	The chemical reactions and physical changes involving phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. The largest single use of phenol is in the production of plastics, but it is also used in the synthesis of caprolactam, a precursor for nylon 6 and other man-made fibers.	18	1.39991334488735	1	0.714329928814609	0.767147287962174
catecholamine metabolism	GO:0006584	The chemical reactions and physical changes involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.	18	1.39991334488735	1	0.714329928814609	0.767147287962174
catecholamine biosynthesis	GO:0042423	The formation from simpler components of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.	6	0.466637781629116	0	0	1
polyol metabolism	GO:0019751	The chemical reactions and physical changes involving a polyol, any polyhydric alcohol.	11	0.855502599653379	0	0	1
glycerol metabolism	GO:0006071	The chemical reactions and physical changes involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.	9	0.699956672443674	0	0	1
glycerol-3-phosphate metabolism	GO:0006072	The chemical reactions and physical changes involving glycerol-3-phosphate, a phosphoric monoester of glycerol.	8	0.622183708838821	0	0	1
sterol metabolism	GO:0016125	The chemical reactions and physical changes involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.	80	6.22183708838821	5	0.803621169916435	0.754665329325125
cholesterol metabolism	GO:0008203	The chemical reactions and physical changes involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.	75	5.83297227036395	4	0.685756731662024	0.844217393420584
cholesterol biosynthesis	GO:0006695	The formation from simpler components of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.	26	2.02209705372617	2	0.989072209127919	0.611015887938427
sterol biosynthesis	GO:0016126	The formation from simpler components of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.	31	2.41096187175043	3	1.24431665019319	0.437451349268559
aldehyde metabolism	GO:0006081	The chemical reactions and physical changes involving aldehydes, any organic compound with the formula R-CH=O.	14	1.08882149046794	0	0	1
amine metabolism	GO:0009308	The chemical reactions and physical changes involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.	294	22.8652512998267	33	1.44323801944176	0.0221316277539499
amine biosynthesis	GO:0009309	The formation from simpler components of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.	67	5.21078856152513	3	0.575728599343117	0.901397244732094
amino acid biosynthesis	GO:0008652	The formation from simpler components of amino acids, organic acids containing one or more amino substituents.	45	3.49978336221837	2	0.571463943051687	0.874545812868877
glutamine family amino acid biosynthesis	GO:0009084	The formation from simpler components of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.	13	1.01104852686308	1	0.989072209127919	0.650946457163423
arginine biosynthesis	GO:0006526	The formation from simpler components of arginine, 2-amino-5-guanidinopentanoic acid, a chiral alpha-amino acid found in peptide linkage in proteins.	6	0.466637781629116	0	0	1
serine family amino acid biosynthesis	GO:0009070	The formation from simpler components of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.	18	1.39991334488735	0	0	1
L-serine biosynthesis	GO:0006564	The formation from simpler components of L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid.	12	0.933275563258232	0	0	1
sulfur amino acid biosynthesis	GO:0000097	The formation from simpler components of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.	6	0.466637781629116	1	2.14298978644383	0.384784738770702
biogenic amine biosynthesis	GO:0042401	The formation from simpler components of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.	20	1.55545927209705	1	0.642896935933148	0.801958138159132
polyamine biosynthesis	GO:0006596	The formation from simpler components of polyamines, any organic compound containing two or more amino groups.	7	0.544410745233969	0	0	1
amine catabolism	GO:0009310	The breakdown into simpler components of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.	55	4.2775129982669	14	3.27292985565966	6.01943197285266e-05
amino acid catabolism	GO:0009063	The breakdown into simpler components of amino acids, organic acids containing one or more amino substituents.	52	4.04419410745234	14	3.46175273194772	3.05468971761734e-05
aromatic amino acid family catabolism	GO:0009074	The breakdown into simpler components of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).	16	1.24436741767764	2	1.60724233983287	0.356800974762934
phenylalanine catabolism	GO:0006559	The breakdown into simpler components of phenylalanine, 2-amino-3-phenylpropanoic acid.	12	0.933275563258232	2	2.14298978644383	0.238485955328307
tyrosine catabolism	GO:0006572	The breakdown into simpler components of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.	8	0.622183708838821	0	0	1
aspartate family amino acid catabolism	GO:0009068	The breakdown into simpler components of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.	5	0.388864818024263	2	5.14317548746518	0.0516153430227439
glutamine family amino acid catabolism	GO:0009065	The breakdown into simpler components of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.	21	1.63323223570191	6	3.67369677676084	0.00431708949720852
arginine catabolism	GO:0006527	The breakdown into simpler components of arginine, 2-amino-5-guanidinopentanoic acid, a chiral alpha-amino acid found in peptide linkage in proteins.	6	0.466637781629116	0	0	1
amino acid metabolism	GO:0006520	The chemical reactions and physical changes involving amino acids, organic acids containing one or more amino substituents.	206	16.0212305025997	24	1.49801227790248	0.0312251772377114
amino acid activation	GO:0043038	The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule.	33	2.56650779896014	6	2.3378070397569	0.0396692168662993
tRNA aminoacylation	GO:0043039	The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.	33	2.56650779896014	6	2.3378070397569	0.0396692168662993
tRNA aminoacylation for protein translation	GO:0006418	The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis.	33	2.56650779896014	6	2.3378070397569	0.0396692168662993
aromatic amino acid family metabolism	GO:0009072	The chemical reactions and physical changes involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).	26	2.02209705372617	3	1.48360831369188	0.32940524860957
L-phenylalanine metabolism	GO:0006558	The chemical reactions and physical changes involving L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid.	13	1.01104852686308	2	1.97814441825584	0.268274884596286
tryptophan metabolism	GO:0006568	The chemical reactions and physical changes involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.	5	0.388864818024263	0	0	1
tyrosine metabolism	GO:0006570	The chemical reactions and physical changes involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.	15	1.16659445407279	1	0.85719591457753	0.703129017048866
aspartate family amino acid metabolism	GO:0009066	The chemical reactions and physical changes involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.	18	1.39991334488735	3	2.14298978644383	0.160314266774028
methionine metabolism	GO:0006555	The chemical reactions and physical changes involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.	8	0.622183708838821	1	1.60724233983287	0.476757755147065
branched chain family amino acid metabolism	GO:0009081	The chemical reactions and physical changes involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.	12	0.933275563258232	4	4.28597957288765	0.0108899304991899
glutamine family amino acid metabolism	GO:0009064	The chemical reactions and physical changes involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.	47	3.65532928942808	7	1.9150121495881	0.0697790404372823
arginine metabolism	GO:0006525	The chemical reactions and physical changes involving arginine, 2-amino-5-guanidinopentanoic acid.	12	0.933275563258232	0	0	1
glutamate metabolism	GO:0006536	The chemical reactions and physical changes involving glutamate, the anion of 2-aminopentanedioic acid.	11	0.855502599653379	4	4.6756140795138	0.00773128171817817
glutamine metabolism	GO:0006541	The chemical reactions and physical changes involving glutamine, 2-amino-4-carbamoylbutanoic acid.	24	1.86655112651646	3	1.60724233983287	0.285614431155593
serine family amino acid metabolism	GO:0009069	The chemical reactions and physical changes involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.	31	2.41096187175043	0	0	1
glycine metabolism	GO:0006544	The chemical reactions and physical changes involving glycine, aminoethanoic acid.	11	0.855502599653379	0	0	1
L-serine metabolism	GO:0006563	The chemical reactions and physical changes involving L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid.	20	1.55545927209705	0	0	1
sulfur amino acid metabolism	GO:0000096	The chemical reactions and physical changes involving amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.	19	1.4776863084922	1	0.676733616771734	0.785256933460783
amino sugar metabolism	GO:0006040	The chemical reactions and physical changes involving any amino sugar, sugars containing an amino group in place of a hydroxyl group.	10	0.777729636048527	2	2.57158774373259	0.17968906149323
glucosamine metabolism	GO:0006041	The chemical reactions and physical changes involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin.	9	0.699956672443674	2	2.85731971525843	0.151204954623315
N-acetylglucosamine metabolism	GO:0006044	The chemical reactions and physical changes involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein.	9	0.699956672443674	2	2.85731971525843	0.151204954623315
aminoglycan metabolism	GO:0006022	The chemical reactions and physical changes involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.	28	2.17764298093588	3	1.37763629128532	0.373121143713707
aminoglycan biosynthesis	GO:0006023	The formation from simpler components of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.	9	0.699956672443674	0	0	1
glycosaminoglycan biosynthesis	GO:0006024	The formation from simpler components of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.	8	0.622183708838821	0	0	1
glycosaminoglycan metabolism	GO:0030203	The chemical reactions and physical changes involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties.	27	2.09987001733102	3	1.42865985762922	0.351306942612832
biogenic amine metabolism	GO:0006576	The chemical reactions and physical changes involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.	51	3.96642114384749	4	1.00846578185592	0.567675514642246
indolalkylamine metabolism	GO:0006586	The chemical reactions and physical changes involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group.	10	0.777729636048527	1	1.2857938718663	0.554981054514678
polyamine metabolism	GO:0006595	The chemical reactions and physical changes involving polyamines, any organic compound containing two or more amino groups.	12	0.933275563258232	1	1.07149489322191	0.621510182350567
thyroid hormone metabolism	GO:0042403	The chemical reactions and physical changes involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
thyroid hormone generation	GO:0006590	The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
amino acid and derivative metabolism	GO:0006519	The chemical reactions and physical changes involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids.	252	19.5987868284229	28	1.42865985762922	0.0366227062528869
amino acid derivative metabolism	GO:0006575	The chemical reactions and physical changes involving compounds derived from amino acids, organic acids containing one or more amino substituents.	57	4.4330589254766	4	0.902311489028979	0.656312235652629
amino acid derivative biosynthesis	GO:0042398	The formation from simpler components of compounds derived from amino acids, organic acids containing one or more amino substituents.	26	2.02209705372617	1	0.49453610456396	0.878161624233234
aromatic compound metabolism	GO:0006725	The chemical reactions and physical changes involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons.	97	7.54397746967071	9	1.1930046233811	0.341406875587312
aromatic compound biosynthesis	GO:0019438	The formation from simpler components of aromatic compounds, any substance containing an aromatic carbon ring.	8	0.622183708838821	3	4.82172701949861	0.0195566048789912
pteridine and derivative biosynthesis	GO:0042559	The formation from simpler components of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.	8	0.622183708838821	3	4.82172701949861	0.0195566048789912
tetrahydrobiopterin biosynthesis	GO:0006729	The formation from simpler components of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.	5	0.388864818024263	2	5.14317548746518	0.0516153430227439
aromatic compound catabolism	GO:0019439	The breakdown into simpler components of aromatic compounds, any substance containing an aromatic carbon ring.	17	1.3221403812825	2	1.51269867278388	0.385531596872848
folic acid and derivative metabolism	GO:0006760	The chemical reactions and physical changes involving folic acid and its derivatives.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
indole and derivative metabolism	GO:0042430	The chemical reactions and physical changes involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan) formed in degradation of tryptophan.	10	0.777729636048527	1	1.2857938718663	0.554981054514678
indole derivative metabolism	GO:0042434		10	0.777729636048527	1	1.2857938718663	0.554981054514678
nucleobase metabolism	GO:0009112	The chemical reactions and physical changes involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine.	26	2.02209705372617	1	0.49453610456396	0.878161624233234
nucleobase biosynthesis	GO:0046112	The formation from simpler components of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid.	20	1.55545927209705	0	0	1
pyrimidine base biosynthesis	GO:0019856	The formation from simpler components of pyrimidine bases, 1,3-diazine, organic nitrogenous bases.	9	0.699956672443674	0	0	1
purine base metabolism	GO:0006144	The chemical reactions and physical changes involving purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.	16	1.24436741767764	1	0.803621169916435	0.726217553201261
pyrimidine base metabolism	GO:0006206	The chemical reactions and physical changes involving pyrimidine bases, 1,3-diazine, organic nitrogenous bases.	10	0.777729636048527	0	0	1
pteridine and derivative metabolism	GO:0042558	The chemical reactions and physical changes involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.	8	0.622183708838821	3	4.82172701949861	0.0195566048789912
tetrahydrobiopterin metabolism	GO:0046146	The chemical reactions and physical changes involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.	5	0.388864818024263	2	5.14317548746518	0.0516153430227439
biosynthesis	GO:0009058	The energy-requiring part of metabolism in which simpler substances are transformed into more complex ones, as in growth and other biosynthetic processes.	1001	77.8507365684575	104	1.33588973700394	0.00181438525937677
coenzyme and prosthetic group biosynthesis	GO:0046138	The formation from simpler components of coenzymes and prosthetic groups.	82	6.37738301559792	24	3.76329913716964	8.8478951927221e-09
coenzyme biosynthesis	GO:0009108	The formation from simpler components of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.	64	4.97746967071057	21	4.21901114206128	7.70048063495201e-09
ATP biosynthesis	GO:0006754	The formation from simpler components of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	41	3.18869150779896	19	5.95855696718527	3.82493129529944e-11
coenzyme A biosynthesis	GO:0015937	The formation from simpler components of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.	0	0	0	0	1
glutathione biosynthesis	GO:0006750	The formation from simpler components of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.	10	0.777729636048527	0	0	1
pyridine nucleotide biosynthesis	GO:0019363	The formation from simpler components of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base.	1	0.0777729636048527	0	0	1
porphyrin biosynthesis	GO:0006779	The formation from simpler components of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.	18	1.39991334488735	3	2.14298978644383	0.160314266774028
hormone biosynthesis	GO:0042446	The formation from simpler components of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.	16	1.24436741767764	1	0.803621169916435	0.726217553201261
C21-steroid hormone biosynthesis	GO:0006700	The formation from simpler components of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.	8	0.622183708838821	0	0	1
macromolecule biosynthesis	GO:0009059	The formation from simpler components of macromolecules, large molecules including proteins, nucleic acids and carbohydrates.	845	65.7181542461005	87	1.32383511067891	0.00504694606650271
carbohydrate biosynthesis	GO:0016051	The formation from simpler components of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.	63	4.89969670710572	6	1.22456559225361	0.365621117636411
polysaccharide biosynthesis	GO:0000271	The formation from simpler components of polysaccharides (synonym:glycans), a polymer of more than about 10 monosaccharide residues joined by glycosidic linkages.	14	1.08882149046794	0	0	1
glucan biosynthesis	GO:0009250	The formation from simpler components of glucans, polysaccharides consisting only of glucose residues.	12	0.933275563258232	0	0	1
glycogen biosynthesis	GO:0005978	The formation from simpler components of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.	12	0.933275563258232	0	0	1
lipid biosynthesis	GO:0008610	The formation from simpler components of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.	158	12.2881282495667	14	1.13931102570431	0.345982735049262
fatty acid biosynthesis	GO:0006633	The formation from simpler components of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.	47	3.65532928942808	6	1.64143898536123	0.155725872039936
icosanoid biosynthesis	GO:0046456	The formation from simpler components of icosanoids, any of a group of C20 polyunsaturated fatty acids.	25	1.94432409012132	1	0.514317548746518	0.867886788221895
leukotriene biosynthesis	GO:0019370	The formation from simpler components of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.	15	1.16659445407279	1	0.85719591457753	0.703129017048866
prostanoid biosynthesis	GO:0046457	The formation from simpler components of prostanoids, any compound based on or derived from the prostanoate structure.	10	0.777729636048527	0	0	1
prostaglandin biosynthesis	GO:0001516	The formation from simpler components of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.	10	0.777729636048527	0	0	1
isoprenoid biosynthesis	GO:0008299	The formation from simpler components of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.	10	0.777729636048527	0	0	1
membrane lipid biosynthesis	GO:0046467	The formation from simpler components of membrane lipids, any lipid found in or associated with a biological membrane.	43	3.34423743500867	4	1.19608732266632	0.432430293669227
glycolipid biosynthesis	GO:0009247	The formation from simpler components of glycolipid, a compound containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid.	11	0.855502599653379	1	1.16890351987845	0.589591496765378
glycosphingolipid biosynthesis	GO:0006688	The formation from simpler components of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.	11	0.855502599653379	1	1.16890351987845	0.589591496765378
phospholipid biosynthesis	GO:0008654	The formation from simpler components of phospholipids, any lipid containing phosphoric acid as a mono- or diester.	30	2.33318890814558	3	1.2857938718663	0.416246509111854
glycerophospholipid biosynthesis	GO:0046474	The formation from simpler components of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.	18	1.39991334488735	2	1.42865985762922	0.4136837631352
phosphoinositide biosynthesis	GO:0046489	The formation from simpler components of phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol.	10	0.777729636048527	1	1.2857938718663	0.554981054514678
GPI anchor biosynthesis	GO:0006506	The formation from simpler components of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage.	7	0.544410745233969	0	0	1
sphingolipid biosynthesis	GO:0030148	The formation from simpler components of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).	13	1.01104852686308	1	0.989072209127919	0.650946457163423
steroid biosynthesis	GO:0006694	The formation from simpler components of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.	61	4.74415077989601	4	0.843143522535276	0.708141403628447
nucleotide biosynthesis	GO:0009165	The formation from simpler components of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).	135	10.4993500866551	31	2.95256370576705	3.95946314113143e-08
cyclic nucleotide biosynthesis	GO:0009190	The formation from simpler components of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.	25	1.94432409012132	3	1.54295264623955	0.307483370901745
cAMP biosynthesis	GO:0006171	The formation from simpler components of cyclic AMP, adenosine 3',5'-phosphate.	13	1.01104852686308	2	1.97814441825584	0.268274884596286
cGMP biosynthesis	GO:0006182	The formation from simpler components of cyclic GMP, guanosine 3',5'-phosphate.	12	0.933275563258232	1	1.07149489322191	0.621510182350567
nucleoside monophosphate biosynthesis	GO:0009124	The formation from simpler components of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.	31	2.41096187175043	2	0.829544433462126	0.706238126807694
purine nucleoside monophosphate biosynthesis	GO:0009127	The formation from simpler components of purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety.	20	1.55545927209705	0	0	1
purine ribonucleoside monophosphate biosynthesis	GO:0009168	The formation from simpler components of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety.	20	1.55545927209705	0	0	1
ribonucleoside monophosphate biosynthesis	GO:0009156	The formation from simpler components of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety.	28	2.17764298093588	2	0.918424194190211	0.65169040816838
nucleoside triphosphate biosynthesis	GO:0009142	The formation from simpler components of a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety.	53	4.12196707105719	23	5.57986019866506	1.89199388136965e-12
purine nucleoside triphosphate biosynthesis	GO:0009145	The formation from simpler components of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety.	51	3.96642114384749	22	5.54656180020755	6.61065365955966e-12
purine ribonucleoside triphosphate biosynthesis	GO:0009206	The formation from simpler components of purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety.	51	3.96642114384749	22	5.54656180020755	6.61065365955966e-12
GTP biosynthesis	GO:0006183	The formation from simpler components of GTP, guanosine triphosphate.	10	0.777729636048527	3	3.85738161559889	0.0372685271436536
ribonucleoside triphosphate biosynthesis	GO:0009201	The formation from simpler components of a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety.	51	3.96642114384749	22	5.54656180020755	6.61065365955966e-12
pyrimidine ribonucleoside triphosphate biosynthesis	GO:0009209	The formation from simpler components of pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety.	7	0.544410745233969	2	3.67369677676084	0.0977020540462852
CTP biosynthesis	GO:0006241	The formation from simpler components of CTP, cytidine 5'-triphosphate.	7	0.544410745233969	2	3.67369677676084	0.0977020540462852
UTP biosynthesis	GO:0006228	The formation from simpler components of UTP, uridine (5'-)triphosphate.	7	0.544410745233969	2	3.67369677676084	0.0977020540462852
purine nucleotide biosynthesis	GO:0006164	The formation from simpler components of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	83	6.45515597920277	25	3.87287310803101	2.26419493219738e-09
purine ribonucleotide biosynthesis	GO:0009152	The formation from simpler components of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	79	6.14406412478336	23	3.74345051302845	1.99986115282994e-08
pyrimidine nucleotide biosynthesis	GO:0006221	The formation from simpler components of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	20	1.55545927209705	4	2.57158774373259	0.0649254338118785
pyrimidine ribonucleotide biosynthesis	GO:0009220	The formation from simpler components of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	11	0.855502599653379	3	3.50671055963535	0.048344994178207
ribonucleotide biosynthesis	GO:0009260	The formation from simpler components of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	87	6.76624783362218	25	3.69480997662729	6.63850770586105e-09
protein biosynthesis	GO:0006412	The formation from simpler components of a protein, rather than of proteins in general.	520	40.4419410745234	40	0.98907220912792	0.552335161102401
cytokine biosynthesis	GO:0042089	The formation from simpler components of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.	30	2.33318890814558	0	0	1
regulation of cytokine biosynthesis	GO:0042035	Any process that modulates the frequency, rate or extent of the formation from simpler components of cytokines.	24	1.86655112651646	0	0	1
negative regulation of cytokine biosynthesis	GO:0042036	Any process that stops, prevents or reduces the rate of the formation from simpler components of cytokines.	6	0.466637781629116	0	0	1
positive regulation of cytokine biosynthesis	GO:0042108	Any process that activates or increases the rate of the formation from simpler components of cytokines.	17	1.3221403812825	0	0	1
glycoprotein biosynthesis	GO:0009101	The synthesis from simpler components of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.	98	7.62175043327556	5	0.656017281564436	0.886458573008623
protein amino acid glycosylation	GO:0006486	The addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins.	92	7.15511265164645	4	0.559040813854911	0.933717549283909
N-linked glycosylation	GO:0006487	The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine or the N1' atom peptidyl-tryptophan.	33	2.56650779896014	3	1.16890351987845	0.478919481760808
O-linked glycosylation	GO:0006493	The formation of O-glycans by addition of glycosyl groups either to the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or to the phenol group of peptidyl-tyrosine.	17	1.3221403812825	1	0.756349336391938	0.747510425471787
lipoprotein biosynthesis	GO:0042158	The formation from simpler components of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.	19	1.4776863084922	0	0	1
protein lipidation	GO:0006497	The covalent or non-covalent attachment of lipid moieties to protein.	19	1.4776863084922	0	0	1
protein prenylation	GO:0018342	The enzymatic addition of prenyl moieties to proteins as a posttranslational modification; geranyl, farnesyl, or geranylgeranyl groups may be added.	7	0.544410745233969	0	0	1
protein amino acid prenylation	GO:0018346	The covalent or non-covalent attachment of a prenyl moiety to a protein amino acid.	7	0.544410745233969	0	0	1
regulation of protein biosynthesis	GO:0006417	Any process that modulates the frequency, rate or extent of the formation from simpler components of proteins.	122	9.48830155979203	8	0.843143522535276	0.74061204392816
negative regulation of protein biosynthesis	GO:0017148	Any process that stops, prevents or reduces the rate of the formation from simpler components of proteins.	11	0.855502599653379	0	0	1
positive regulation of protein biosynthesis	GO:0045727	Any process that activates or increases the rate of the formation from simpler components of proteins.	20	1.55545927209705	0	0	1
regulation of translation	GO:0006445	Any process that modulates the frequency, rate or extent that mRNAs are effectively translated into protein.	90	6.99956672443674	8	1.14292788610337	0.401137527646592
negative regulation of translation	GO:0016478	Any process that stops, prevents or reduces the rate that mRNAs are effectively translated into protein.	5	0.388864818024263	0	0	1
regulation of translational initiation	GO:0006446	Any process that modulates the frequency, rate or extent of translational initiation.	37	2.87759965337955	3	1.04253557178348	0.557131264176124
translation	GO:0043037	A ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in a polypeptide chain.	166	12.9103119584055	18	1.39423431889116	0.0958265714739384
translational elongation	GO:0006414	The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.	30	2.33318890814558	2	0.85719591457753	0.688897044385815
translational initiation	GO:0006413	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.	59	4.58860485268631	6	1.30758698833861	0.309243825384082
translational termination	GO:0006415	The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA).	6	0.466637781629116	0	0	1
nitric oxide biosynthesis	GO:0006809	The formation from simpler components of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.	19	1.4776863084922	4	2.70693446708694	0.0552193514722824
organic acid biosynthesis	GO:0016053	The formation from simpler components of organic acids, any acidic compound containing carbon in covalent linkage.	59	4.58860485268631	7	1.52551815306171	0.172740012353591
carboxylic acid biosynthesis	GO:0046394	The formation from simpler components of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.	59	4.58860485268631	7	1.52551815306171	0.172740012353591
regulation of biosynthesis	GO:0009889	Any process that modulates the frequency, rate or extent of the formation of substances from simpler components.	129	10.032712305026	11	1.09641337911079	0.421153762229093
negative regulation of biosynthesis	GO:0009890	Any process that stops, prevents, or reduces the rate of the formation of substances from simpler components.	11	0.855502599653379	0	0	1
positive regulation of biosynthesis	GO:0009891	Any process that activates or increases the rate of the formation of substances from simpler components.	26	2.02209705372617	3	1.48360831369188	0.32940524860957
vitamin biosynthesis	GO:0009110	The formation from simpler components of a vitamin, an organic substance needed for the normal nutrition of an organism.	2	0.155545927209705	0	0	1
water-soluble vitamin biosynthesis	GO:0042364	The formation from simpler components of any of a diverse group of vitamins that are soluble in water.	1	0.0777729636048527	0	0	1
carbohydrate metabolism	GO:0005975	The chemical reactions and physical changes involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.	375	29.1648613518198	58	1.98869452181987	4.79172288293161e-07
carbohydrate catabolism	GO:0016052	The breakdown into simpler components of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.	91	7.07733968804159	18	2.54332853775751	0.000202712316363017
polysaccharide catabolism	GO:0000272	The breakdown into simpler components of polysaccharides (synonym:glycans), a polymer of more than about 10 monosaccharide residues joined by glycosidic linkages.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
glucan catabolism	GO:0009251	The breakdown into simpler components of glucans, polysaccharides consisting only of glucose residues.	6	0.466637781629116	1	2.14298978644383	0.384784738770702
main pathways of carbohydrate metabolism	GO:0006092		118	9.17720970537262	32	3.48689863556961	2.85234153633289e-10
TCA intermediate metabolism	GO:0006100	The chemical reactions and physical changes involving intermediates of the tricarboxylic acid cycle.	27	2.09987001733102	9	4.28597957288765	0.00013338326363402
tricarboxylic acid cycle	GO:0006099	A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two C02 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.	39	3.03314558058925	16	5.27505178201557	1.18288890231665e-08
oligosaccharide metabolism	GO:0009311	The chemical reactions and physical changes involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.	13	1.01104852686308	0	0	1
polysaccharide metabolism	GO:0005976	The chemical reactions and physical changes involving polysaccharides (synonym:glycans), a polymer of more than about 10 monosaccharide residues joined by glycosidic linkages.	37	2.87759965337955	4	1.39004742904464	0.324110906205762
glucan metabolism	GO:0006073	The chemical reactions and physical changes involving glucans, polysaccharides consisting only of glucose residues.	34	2.64428076256499	4	1.51269867278388	0.270310185568666
glycogen metabolism	GO:0005977	The chemical reactions and physical changes involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages.	33	2.56650779896014	4	1.5585380265046	0.252717811283259
proteoglycan metabolism	GO:0006029	The chemical reactions and physical changes involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.	5	0.388864818024263	0	0	1
catabolism	GO:0009056	Any metabolic process involving the breakdown of complex substances into smaller products, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.	826	64.2404679376083	84	1.30758698833861	0.00780984754812141
coenzyme and prosthetic group catabolism	GO:0046139	The breakdown into simpler components of coenzymes and prosthetic groups.	7	0.544410745233969	0	0	1
DNA catabolism	GO:0006308	The breakdown into simpler components of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.	9	0.699956672443674	0	0	1
lipid catabolism	GO:0016042	The breakdown into simpler components of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.	80	6.22183708838821	3	0.482172701949861	0.953514077501747
membrane lipid catabolism	GO:0046466	The breakdown into simpler components of membrane lipids, any lipid found in or associated with a biological membrane.	19	1.4776863084922	1	0.676733616771734	0.785256933460783
phospholipid catabolism	GO:0009395	The breakdown into simpler components of phospholipids, any lipid containing phosphoric acid as a mono- or diester.	6	0.466637781629116	0	0	1
sphingolipid catabolism	GO:0030149	The breakdown into simpler components of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).	14	1.08882149046794	1	0.918424194190211	0.678093385646598
steroid catabolism	GO:0006706	The breakdown into simpler components of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.	10	0.777729636048527	1	1.2857938718663	0.554981054514678
macromolecule catabolism	GO:0009057	The breakdown into simpler components of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates.	555	43.1639948006932	47	1.08887048608497	0.292965634387661
protein catabolism	GO:0030163	The breakdown into simpler components of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.	530	41.2196707105719	45	1.09171177799968	0.291731815955919
proteolysis and peptidolysis	GO:0006508	Destruction of a protein or peptide by hydrolysis of peptide bonds.	522	40.5974870017331	44	1.08381092647734	0.311330170053261
collagen catabolism	GO:0030574	The proteolytic breakdown into simpler components of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.	24	1.86655112651646	0	0	1
glycoprotein catabolism	GO:0006516	The breakdown into simpler components of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
modification-dependent protein catabolism	GO:0019941	Destruction of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.	126	9.79939341421144	27	2.75527258257063	1.23037888061865e-06
ubiquitin-dependent protein catabolism	GO:0006511	Destruction of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein.	126	9.79939341421144	27	2.75527258257063	1.23037888061865e-06
RNA catabolism	GO:0006401	The breakdown into simpler components of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.	24	1.86655112651646	2	1.07149489322191	0.566803918253758
mRNA catabolism	GO:0006402	The breakdown into simpler components of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
nucleotide catabolism	GO:0009166	The breakdown into simpler components of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).	12	0.933275563258232	1	1.07149489322191	0.621510182350567
organic acid catabolism	GO:0016054	The breakdown into simpler components of organic acids, any acidic compound containing carbon in covalent linkage.	6	0.466637781629116	1	2.14298978644383	0.384784738770702
carboxylic acid catabolism	GO:0046395	The breakdown into simpler components of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.	6	0.466637781629116	1	2.14298978644383	0.384784738770702
regulation of catabolism	GO:0009894	Any process that modulates the frequency, rate, or extent of the breakdown of substances into simpler components.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
coenzyme and prosthetic group metabolism	GO:0006731	The chemical reactions and physical changes involving coenzymes and prosthetic groups.	133	10.3438041594454	30	2.90028692902172	9.91753534953675e-08
coenzyme metabolism	GO:0006732	The chemical reactions and physical changes involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.	109	8.47725303292894	27	3.18499399453119	5.44182023001141e-08
acetyl-CoA metabolism	GO:0006084	The chemical reactions and physical changes involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.	10	0.777729636048527	2	2.57158774373259	0.17968906149323
ATP metabolism	GO:0046034	The chemical reactions and physical changes involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.	47	3.65532928942808	20	5.47146328453743	8.05554179487832e-11
glutathione metabolism	GO:0006749	The chemical reactions and physical changes involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.	11	0.855502599653379	0	0	1
group transfer coenzyme metabolism	GO:0006752		51	3.96642114384749	20	5.04232890927959	4.71126399034329e-10
coenzyme A metabolism	GO:0015936	The chemical reactions and physical changes involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.	3	0.233318890814558	0	0	1
nucleoside phosphate metabolism	GO:0006753		41	3.18869150779896	19	5.95855696718527	3.82493129529944e-11
oxidoreduction coenzyme metabolism	GO:0006733		19	1.4776863084922	2	1.35346723354347	0.441173668987211
pyridine nucleotide metabolism	GO:0019362	The chemical reactions and physical changes involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base.	15	1.16659445407279	2	1.71439182915506	0.327594546014837
nicotinamide metabolism	GO:0006769	The chemical reactions and physical changes involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms.	15	1.16659445407279	2	1.71439182915506	0.327594546014837
NADPH metabolism	GO:0006739	The chemical reactions and physical changes involving NADPH, reduced nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.	14	1.08882149046794	2	1.83684838838042	0.298036386882161
NADPH regeneration	GO:0006740		10	0.777729636048527	2	2.57158774373259	0.17968906149323
porphyrin metabolism	GO:0006778	The chemical reactions and physical changes involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.	24	1.86655112651646	3	1.60724233983287	0.285614431155593
electron transport	GO:0006118	The transport of electrons from an electron donor to an electron acceptor.	285	22.165294627383	47	2.1204319992181	8.92396627886185e-07
ATP synthesis coupled electron transport	GO:0042773	The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.	30	2.33318890814558	14	6.00037140204271	1.29443267790302e-08
ATP synthesis coupled electron transport (sensu Eukarya)	GO:0042775	The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane of eukaryotes.	30	2.33318890814558	14	6.00037140204271	1.29443267790302e-08
mitochondrial electron transport, NADH to ubiquinone	GO:0006120	The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.	26	2.02209705372617	13	6.42896935933148	1.49870926837869e-08
energy pathways	GO:0006091		277	21.5431109185442	62	2.87795018251662	3.47523082652415e-14
energy derivation by oxidation of organic compounds	GO:0015980		177	13.7658145580589	41	2.97839258454905	2.16412336737622e-10
cellular respiration	GO:0045333	The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).	14	1.08882149046794	8	7.34739355352169	2.61800565397754e-06
aerobic respiration	GO:0009060	The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.	14	1.08882149046794	8	7.34739355352169	2.61800565397754e-06
energy reserve metabolism	GO:0006112		45	3.49978336221837	4	1.14292788610337	0.467664791717456
glycerol ether metabolism	GO:0006662	The chemical reactions and physical changes involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol.	16	1.24436741767764	0	0	1
acylglycerol metabolism	GO:0006639	The chemical reactions and physical changes involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.	16	1.24436741767764	0	0	1
triacylglycerol metabolism	GO:0006641	The chemical reactions and physical changes involving triacylglycerol, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triacylglycerols are important components of plant oils, animal fats and animal plasma lipoproteins.	15	1.16659445407279	0	0	1
heterocycle metabolism	GO:0046483	The chemical reactions and physical changes involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).	71	5.52188041594454	7	1.26768409902311	0.314202853072269
hormone metabolism	GO:0042445	The chemical reactions and physical changes involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.	33	2.56650779896014	2	0.7792690132523	0.738495502397773
C21-steroid hormone metabolism	GO:0008207	The chemical reactions and physical changes involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.	8	0.622183708838821	0	0	1
estrogen metabolism	GO:0008210	The chemical reactions and physical changes involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.	4	0.311091854419411	0	0	1
lipid metabolism	GO:0006629	The chemical reactions and physical changes involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.	524	40.7530329289428	38	0.932445937612962	0.696342047928421
fatty acid metabolism	GO:0006631	The chemical reactions and physical changes involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.	134	10.4215771230503	13	1.24741196524342	0.243293177357973
fatty acid oxidation	GO:0019395	The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.	23	1.78877816291161	1	0.559040813854911	0.844664560448951
fatty acid beta-oxidation	GO:0006635	The metabolic oxidation of a long-chain fatty acid by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A.	21	1.63323223570191	1	0.612282796126807	0.817360440672319
icosanoid metabolism	GO:0006690	The chemical reactions and physical changes involving icosanoids, any of a group of C20 polyunsaturated fatty acids.	42	3.26646447140381	1	0.306141398063404	0.966642791368591
leukotriene metabolism	GO:0006691	The chemical reactions and physical changes involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.	18	1.39991334488735	1	0.714329928814609	0.767147287962174
prostanoid metabolism	GO:0006692	The chemical reactions and physical changes involving prostanoids, any compound based on or derived from the prostanoate structure.	22	1.71100519930676	0	0	1
prostaglandin metabolism	GO:0006693	The chemical reactions and physical changes involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.	22	1.71100519930676	0	0	1
glycerolipid metabolism	GO:0046486	The chemical reactions and physical changes involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.	16	1.24436741767764	0	0	1
isoprenoid metabolism	GO:0006720	The chemical reactions and physical changes involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.	14	1.08882149046794	1	0.918424194190211	0.678093385646598
membrane lipid metabolism	GO:0006643	The chemical reactions and physical changes involving membrane lipids, any lipid found in or associated with a biological membrane.	106	8.24393414211438	8	0.970410469333053	0.587379209777343
glycolipid metabolism	GO:0006664	The chemical reactions and physical changes involving glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid.	25	1.94432409012132	4	2.05727019498607	0.125242206350472
glycosphingolipid metabolism	GO:0006687	The chemical reactions and physical changes involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide.	23	1.78877816291161	3	1.67712244156473	0.263877345481983
phospholipid metabolism	GO:0006644	The chemical reactions and physical changes involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.	57	4.4330589254766	3	0.676733616771734	0.830093986602335
glycerophospholipid metabolism	GO:0006650	The chemical reactions and physical changes involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.	20	1.55545927209705	2	1.2857938718663	0.467934044192153
phosphoinositide metabolism	GO:0030384	The chemical reactions and physical changes involving phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol. They are important constituents of cell membranes.	10	0.777729636048527	1	1.2857938718663	0.554981054514678
GPI anchor metabolism	GO:0006505	The chemical reactions and physical changes involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate moiety, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain.	7	0.544410745233969	0	0	1
sphingolipid metabolism	GO:0006665	The chemical reactions and physical changes involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).	50	3.88864818024263	5	1.2857938718663	0.348412837921869
sphingoid metabolism	GO:0046519	The chemical reactions and physical changes involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.	21	1.63323223570191	2	1.22456559225361	0.493912087895391
ceramide metabolism	GO:0006672	The chemical reactions and physical changes involving ceramides, any N-acylated sphingoid.	18	1.39991334488735	2	1.42865985762922	0.4136837631352
neutral lipid metabolism	GO:0006638	The chemical reactions and physical changes involving neutral lipids, lipids only soluble in solvents of very low polarity.	16	1.24436741767764	0	0	1
regulation of lipid metabolism	GO:0019216	Any process that modulates the frequency, rate or extent of the chemical reactions and physical changes involving lipids.	8	0.622183708838821	0	0	1
steroid metabolism	GO:0008202	The chemical reactions and physical changes involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.	150	11.6659445407279	9	0.771476323119777	0.832590345678392
bile acid metabolism	GO:0008206	The chemical reactions and physical changes involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.	9	0.699956672443674	0	0	1
nitrogen metabolism	GO:0006807	The chemical reactions and physical changes involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.	42	3.26646447140381	6	1.83684838838042	0.104692840319246
nitric oxide metabolism	GO:0046209	The chemical reactions and physical changes involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.	19	1.4776863084922	4	2.70693446708694	0.0552193514722824
urea cycle	GO:0000050	A cyclic metabolic pathway that converts waste nitrogen, in the form of ammonium to urea.	9	0.699956672443674	0	0	1
urea cycle intermediate metabolism	GO:0000051		13	1.01104852686308	1	0.989072209127919	0.650946457163423
nucleobase, nucleoside, nucleotide and nucleic acid metabolism	GO:0006139	The chemical reactions and physical changes involving nucleobases, nucleosides, nucleotides and nucleic acids.	2499	194.354636048527	160	0.823237372943606	0.996205421373714
DNA metabolism	GO:0006259	The chemical reactions and physical changes involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.	491	38.1865251299827	35	0.916553676483102	0.727904714487528
DNA modification	GO:0006304	The enzymatic modification of the chemical structure of specific sites in DNA.	20	1.55545927209705	1	0.642896935933148	0.801958138159132
DNA alkylation	GO:0006305	The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis.	11	0.855502599653379	1	1.16890351987845	0.589591496765378
DNA packaging	GO:0006323		153	11.8992634315425	7	0.588271706082619	0.957666724919641
DNA recombination	GO:0006310	The processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.	75	5.83297227036395	5	0.85719591457753	0.702462178825818
regulation of DNA recombination	GO:0000018	Any process that modulates the frequency, rate or extent of DNA recombination, the processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.	9	0.699956672443674	2	2.85731971525843	0.151204954623315
DNA repair	GO:0006281	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.	183	14.232452339688	17	1.19445332359164	0.257975367181966
base-excision repair	GO:0006284	In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.	12	0.933275563258232	1	1.07149489322191	0.621510182350567
double-strand break repair	GO:0006302	The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.	20	1.55545927209705	0	0	1
nucleotide-excision repair	GO:0006289	In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).	21	1.63323223570191	2	1.22456559225361	0.493912087895391
regulation of DNA metabolism	GO:0051052	Any process that modulates the frequency, rate or extent of the chemical reactions and physical changes involving DNA.	32	2.48873483535529	7	2.81267409470752	0.0102289732411051
gene silencing	GO:0016458	Any mechanism, at the level of transcription or post-transcription, causing long-term gene inactivation.	16	1.24436741767764	1	0.803621169916435	0.726217553201261
nucleoside metabolism	GO:0009116	The chemical reactions and physical changes involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).	27	2.09987001733102	5	2.38109976271536	0.0544533268519111
purine nucleoside metabolism	GO:0042278	The chemical reactions and physical changes involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).	7	0.544410745233969	3	5.51054516514127	0.0129664671643897
purine ribonucleoside metabolism	GO:0046128	The chemical reactions and physical changes involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule.	7	0.544410745233969	3	5.51054516514127	0.0129664671643897
pyrimidine nucleoside metabolism	GO:0006213	The chemical reactions and physical changes involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).	8	0.622183708838821	1	1.60724233983287	0.476757755147065
ribonucleoside metabolism	GO:0009119	The chemical reactions and physical changes involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule.	8	0.622183708838821	3	4.82172701949861	0.0195566048789912
nucleotide metabolism	GO:0009117	The chemical reactions and physical changes involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).	187	14.5435441941075	35	2.40656607033799	1.11171720535888e-06
cyclic nucleotide metabolism	GO:0009187	The chemical reactions and physical changes involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.	35	2.72205372616984	3	1.10210903302825	0.518889014018474
cAMP metabolism	GO:0046058	The chemical reactions and physical changes involving cyclic AMP, adenosine 3',5'-phosphate.	17	1.3221403812825	2	1.51269867278388	0.385531596872848
cGMP metabolism	GO:0046068	The chemical reactions and physical changes involving cyclic GMP, guanosine 3',5'-phosphate.	12	0.933275563258232	1	1.07149489322191	0.621510182350567
deoxyribonucleotide metabolism	GO:0009262	The chemical reactions and physical changes involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	12	0.933275563258232	2	2.14298978644383	0.238485955328307
pyrimidine deoxyribonucleotide metabolism	GO:0009219	The chemical reactions and physical changes involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
nucleoside diphosphate metabolism	GO:0009132	The chemical reactions and physical changes involving a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety.	12	0.933275563258232	1	1.07149489322191	0.621510182350567
nucleoside monophosphate metabolism	GO:0009123	The chemical reactions and physical changes involving a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.	31	2.41096187175043	2	0.829544433462126	0.706238126807694
purine nucleoside monophosphate metabolism	GO:0009126	The chemical reactions and physical changes involving purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety.	20	1.55545927209705	0	0	1
purine ribonucleoside monophosphate metabolism	GO:0009167	The chemical reactions and physical changes involving purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety.	20	1.55545927209705	0	0	1
ribonucleoside monophosphate metabolism	GO:0009161	The chemical reactions and physical changes involving a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety.	28	2.17764298093588	2	0.918424194190211	0.65169040816838
nucleoside triphosphate metabolism	GO:0009141	The chemical reactions and physical changes involving a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety.	62	4.82192374350087	24	4.97726660077276	1.22854487347841e-11
purine nucleoside triphosphate metabolism	GO:0009144	The chemical reactions and physical changes involving purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety.	57	4.4330589254766	23	5.18829106191663	1.18401405433039e-11
purine ribonucleoside triphosphate metabolism	GO:0009205	The chemical reactions and physical changes involving purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety.	57	4.4330589254766	23	5.18829106191663	1.18401405433039e-11
GTP metabolism	GO:0046039	The chemical reactions and physical changes involving GTP, guanosine triphosphate.	10	0.777729636048527	3	3.85738161559889	0.0372685271436536
pyrimidine nucleoside triphosphate metabolism	GO:0009147	The chemical reactions and physical changes involving pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety.	12	0.933275563258232	3	3.21448467966574	0.0608300154045459
pyrimidine ribonucleoside triphosphate metabolism	GO:0009208	The chemical reactions and physical changes involving pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety.	7	0.544410745233969	2	3.67369677676084	0.0977020540462852
CTP metabolism	GO:0046036	The chemical reactions and physical changes involving CTP, cytidine triphosphate.	7	0.544410745233969	2	3.67369677676084	0.0977020540462852
UTP metabolism	GO:0046051	The chemical reactions and physical changes involving UTP, uridine (5'-)triphosphate.	7	0.544410745233969	2	3.67369677676084	0.0977020540462852
ribonucleoside triphosphate metabolism	GO:0009199	The chemical reactions and physical changes involving a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety.	57	4.4330589254766	23	5.18829106191663	1.18401405433039e-11
purine nucleotide metabolism	GO:0006163	The chemical reactions and physical changes involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	88	6.84402079722704	25	3.65282349962016	8.58556517761949e-09
purine ribonucleotide metabolism	GO:0009150	The chemical reactions and physical changes involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	84	6.53292894280762	23	3.52062607772914	7.07321292861344e-08
pyrimidine nucleotide metabolism	GO:0006220	The chemical reactions and physical changes involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	35	2.72205372616984	4	1.46947871070434	0.288104429078766
pyrimidine ribonucleotide metabolism	GO:0009218	The chemical reactions and physical changes involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	13	1.01104852686308	3	2.96721662738376	0.0746468443544225
ribonucleotide metabolism	GO:0009259	The chemical reactions and physical changes involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.	94	7.31065857885615	25	3.41966455283589	3.6748314914374e-08
nucleotide-sugar metabolism	GO:0009225	The chemical reactions and physical changes involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.	12	0.933275563258232	2	2.14298978644383	0.238485955328307
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism	GO:0019219	Any process that modulates the frequency, rate or extent of the chemical reactions and physical changes involving nucleobases, nucleosides, nucleotides and nucleic acids.	1583	123.114601386482	66	0.53608588466946	0.999999998006008
negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism	GO:0045934	Any process that stops, prevents or reduces the rate of the chemical reactions and physical changes involving nucleobases, nucleosides, nucleotides and nucleic acids.	117	9.09943674176776	5	0.549484560626622	0.954609627612525
negative regulation of transcription	GO:0016481	Any process that stops, prevents or reduces the rate of transcription.	116	9.02166377816291	5	0.554221496494093	0.952260479886928
negative regulation of transcription, DNA-dependent	GO:0045892	Any process that stops, prevents or reduces the rate of DNA-dependent transcription.	82	6.37738301559792	1	0.156804130715402	0.998691710962271
negative regulation of transcription from Pol II promoter	GO:0000122	Any process that stops, prevents or reduces the rate of transcription from Pol II promoter.	64	4.97746967071057	0	0	1
positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism	GO:0045935	Any process that activates or increases the rate of the chemical reactions and physical changes involving nucleobases, nucleosides, nucleotides and nucleic acids.	38	2.9553726169844	5	1.69183404192934	0.170068093739003
positive regulation of transcription	GO:0045941	Any process that activates or increases the rate of transcription.	36	2.7998266897747	5	1.78582482203652	0.144514020078151
positive regulation of transcription, DNA-dependent	GO:0045893	Any process that activates or increases the rate of DNA-dependent transcription.	23	1.78877816291161	4	2.23616325541964	0.0988858697277758
regulation of transcription	GO:0045449	Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.	1562	121.48136915078	60	0.493902895723289	0.999999999939758
regulation of transcription, DNA-dependent	GO:0006355	Any process that modulates the frequency, rate or extent of DNA-dependent transcription.	1525	118.6037694974	59	0.497454678295813	0.999999999863318
regulation of transcription from Pol II promoter	GO:0006357	Any process that modulates the frequency, rate or extent of transcription from Pol II promoter.	288	22.3986135181976	10	0.44645620550913	0.999167917875654
regulation of transcription from Pol III promoter	GO:0006359	Any process that modulates the frequency, rate or extent of transcription from Pol III promoter.	6	0.466637781629116	0	0	1
RNA localization	GO:0006403	The process that leads to the specific localization of RNA to regions of cells.	51	3.96642114384749	2	0.504232890927959	0.914674019976109
RNA metabolism	GO:0016070	The chemical reactions and physical changes involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.	337	26.2094887348354	32	1.22093186646058	0.141591916243849
mRNA metabolism	GO:0016071	The chemical reactions and physical changes involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.	199	15.4768197573657	19	1.2276423902241	0.207733891672548
mRNA processing	GO:0006397	Any process involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.	184	14.3102253032929	17	1.18796172944169	0.265176880608557
mRNA polyadenylation	GO:0006378	The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.	10	0.777729636048527	0	0	1
nuclear mRNA splicing, via spliceosome	GO:0000398	The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.	102	7.93284228769497	13	1.63875689551587	0.0530741309346767
spliceosomal snRNP biogenesis	GO:0000387	The formation and assembly from one or more snRNA and multiple protein components of a ribonucleoprotein complex that in involved in formation of the spliceosome.	6	0.466637781629116	0	0	1
spliceosome assembly	GO:0000245	Formation of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.	31	2.41096187175043	4	1.65908886692425	0.218334667649271
mRNA splice site selection	GO:0006376	Selection of a splice site by components of the assembling spliceosome.	18	1.39991334488735	2	1.42865985762922	0.4136837631352
RNA modification	GO:0009451	The enzymatic modification of the chemical structure of specific sites in RNA.	37	2.87759965337955	7	2.43258300082813	0.022293777531031
tRNA modification	GO:0006400	The enzymatic modification of the chemical structure of specific sites in tRNA.	36	2.7998266897747	7	2.50015475085113	0.0193393141081339
RNA processing	GO:0006396	Any process involved in the conversion of a primary RNA transcript into a mature RNA molecule.	279	21.6986568457539	25	1.15214504647518	0.259342052588386
RNA splicing	GO:0008380	The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.	135	10.4993500866551	17	1.61914783864645	0.0333985072716991
RNA splicing, via transesterification reactions	GO:0000375	Splicing of RNA via a series of two transesterification reactions.	102	7.93284228769497	13	1.63875689551587	0.0530741309346767
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure.	102	7.93284228769497	13	1.63875689551587	0.0530741309346767
tRNA processing	GO:0008033	The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.	14	1.08882149046794	1	0.918424194190211	0.678093385646598
rRNA metabolism	GO:0016072	The chemical reactions and physical changes involving rRNA, ribosomal RNA, a structural constituent of ribosomes.	13	1.01104852686308	1	0.989072209127919	0.650946457163423
tRNA metabolism	GO:0006399	The chemical reactions and physical changes involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.	47	3.65532928942808	8	2.18858531381497	0.0273262261025914
transcription	GO:0006350	The synthesis of either RNA on a template of DNA or DNA on a template of RNA.	1634	127.081022530329	66	0.519353705894587	0.999999999745079
transcription, DNA-dependent	GO:0006351	The synthesis of RNA on a template of DNA.	1577	122.647963604853	65	0.529972109520033	0.999999998731834
RNA elongation	GO:0006354		4	0.311091854419411	0	0	1
transcription from Pol I promoter	GO:0006360	The synthesis of RNA from a DNA template by RNA Polymerase I (Pol I), originating at a Pol I-specific promoter.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
transcription from Pol II promoter	GO:0006366	The synthesis of RNA from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).	541	42.0751733102253	26	0.617941602005983	0.997678889039155
RNA elongation from Pol II promoter	GO:0006368		7	0.544410745233969	0	0	1
transcription initiation from Pol II promoter	GO:0006367		36	2.7998266897747	4	1.42865985762922	0.306053230203843
transcription from Pol III promoter	GO:0006383	The synthesis of RNA from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III-specific promoter.	26	2.02209705372617	3	1.48360831369188	0.32940524860957
transcription initiation	GO:0006352	Processes involved in starting transcription, which is the synthesis of RNA by RNA polymerases using a DNA template.	55	4.2775129982669	6	1.40268422385414	0.254564256069438
one-carbon compound metabolism	GO:0006730	The chemical reactions and physical changes involving compounds containing a single carbon atom.	40	3.11091854419411	2	0.642896935933148	0.828477914020744
organic acid metabolism	GO:0006082	The chemical reactions and physical changes involving organic acids, any acidic compound containing carbon in covalent linkage.	396	30.7980935875217	46	1.49359894206691	0.00446545774075385
carboxylic acid metabolism	GO:0019752	The chemical reactions and physical changes involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).	394	30.642547660312	46	1.50118066258501	0.00406640974298056
oxidative phosphorylation	GO:0006119	The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.	71	5.52188041594454	34	6.15732276668367	2.22981403849619e-19
oxygen and reactive oxygen species metabolism	GO:0006800	The chemical reactions and physical changes involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH).	59	4.58860485268631	3	0.653793494169303	0.847185625667374
response to oxidative stress	GO:0006979	A change in state or activity of an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.	43	3.34423743500867	1	0.29902183066658	0.969237080341441
superoxide metabolism	GO:0006801	The chemical reactions and physical changes involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.	15	1.16659445407279	1	0.85719591457753	0.703129017048866
phosphorus metabolism	GO:0006793	The chemical reactions and physical changes involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).	825	64.1626949740035	99	1.54295264623955	1.45220938214249e-05
phosphate metabolism	GO:0006796	The chemical reactions and physical changes involving the phosphate group, the anion or salt of any phosphoric acid.	825	64.1626949740035	99	1.54295264623955	1.45220938214249e-05
dephosphorylation	GO:0016311	The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.	143	11.1215337954939	18	1.61848179675478	0.0293654544430683
protein amino acid dephosphorylation	GO:0006470	The process of removing one or more phosphoric residues from a protein.	141	10.9659878682842	18	1.64143898536123	0.0259341478548875
phosphorylation	GO:0016310	The process of introducing a phosphoric group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.	682	53.0411611785095	79	1.48940932371609	0.000295701870103033
protein amino acid phosphorylation	GO:0006468	The process of introducing a phosphoric group on to a protein.	599	46.5860051993068	48	1.03035235141206	0.436253443649551
peptidyl-tyrosine phosphorylation	GO:0018108	The posttranslational phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.	22	1.71100519930676	2	1.16890351987845	0.51906762486396
regulation of protein kinase activity	GO:0045859	Any process that modulates the frequency, rate or extent of protein kinase activity.	51	3.96642114384749	7	1.76481511824786	0.0986713413225158
negative regulation of protein kinase activity	GO:0006469	Any process that stops, prevents or reduces the rate of protein kinase activity.	10	0.777729636048527	1	1.2857938718663	0.554981054514678
regulation of phosphorylation	GO:0042325	Any process that modulates the frequency, rate or extent of addition of phosphoric groups into a molecule.	6	0.466637781629116	0	0	1
regulation of phosphate metabolism	GO:0019220	Any process that modulates the frequency, rate or extent of the chemical reactions and physical changes involving phosphates.	6	0.466637781629116	0	0	1
protein metabolism	GO:0019538	The chemical reactions and physical changes involving a specific protein, rather than of proteins in general. Includes protein modification.	2314	179.966637781629	222	1.23356196868763	0.000871699265614047
cytokine metabolism	GO:0042107	The chemical reactions and physical changes involving cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.	30	2.33318890814558	0	0	1
glycoprotein metabolism	GO:0009100	The chemical reactions and physical changes involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.	109	8.47725303292894	7	0.825739183767346	0.752144294478466
beta-amyloid metabolism	GO:0050435	The chemical reactions and physical changes involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP).	6	0.466637781629116	1	2.14298978644383	0.384784738770702
lipoprotein metabolism	GO:0042157	The chemical reactions and physical changes involving any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.	40	3.11091854419411	0	0	1
protein complex assembly	GO:0006461	The aggregation and bonding together of a set of components to form a protein complex.	168	13.0658578856152	9	0.688818145642658	0.912137427417251
protein complex assembly, multichaperone pathway	GO:0006462		7	0.544410745233969	1	1.83684838838042	0.432631852891438
protein folding	GO:0006457		145	11.2770797227036	31	2.7489386226107	2.21152656211051e-07
protein localization	GO:0008104	The process that leads to the specific localization of proteins to regions of cells, excluding that due to targeting to membrane bound subcellular organelles.	7	0.544410745233969	0	0	1
protein modification	GO:0006464	The covalent alteration of one or more amino acid residues within a protein, resulting in a change in the properties of that protein.	1051	81.7393847487002	102	1.24786845794826	0.013373568864335
peptide cross-linking	GO:0018149	The formation of a covalent cross-link between or within protein chains.	8	0.622183708838821	0	0	1
peptidyl-amino acid modification	GO:0018193		36	2.7998266897747	6	2.14298978644383	0.0573276237462762
peptidyl-tyrosine modification	GO:0018212	The modification of peptidyl-tyrosine.	24	1.86655112651646	2	1.07149489322191	0.566803918253758
protein amino acid acetylation	GO:0006473	The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.	5	0.388864818024263	0	0	1
protein amino acid ADP-ribosylation	GO:0006471	The transfer, from NAD, of ADP-ribose to protein amino acids.	31	2.41096187175043	6	2.48863330038638	0.0300807592382807
protein amino acid alkylation	GO:0008213	The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom.	13	1.01104852686308	2	1.97814441825584	0.268274884596286
protein amino acid methylation	GO:0006479	The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.	11	0.855502599653379	2	2.3378070397569	0.20887663200768
protein amino acid deacetylation	GO:0006476	The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.	8	0.622183708838821	0	0	1
protein processing	GO:0016485	The post translational modification of a protein, particularly secretory proteins and proteins targeted for membranes or specific cellular locations.	9	0.699956672443674	0	0	1
ubiquitin cycle	GO:0006512	The cyclical process by which one or more ubiquitin moieties are added to (ubiquitination) and removed from (deubiquitination) a protein.	69	5.36633448873483	12	2.23616325541964	0.00661683960728899
protein ubiquitination	GO:0016567	The process by which one or more ubiquitin moieties are added to a protein.	10	0.777729636048527	0	0	1
protein stabilization	GO:0050821	The processes involved in maintaining the structure and integrity of a protein and preventing it from being degraded.	8	0.622183708838821	0	0	1
regulation of metabolism	GO:0019222	Any process that modulates the frequency, rate or extent of chemical reactions and physical changes involving a substance.	1703	132.447357019064	77	0.581363054220227	0.999999975167537
negative regulation of metabolism	GO:0009892	Any process that stops, prevents or reduces the rate of chemical reactions and physical changes involving a substance.	131	10.1882582322357	5	0.490761019796296	0.978091775155295
positive regulation of metabolism	GO:0009893	Any process that activates or increases the rate of chemical reactions and physical changes involving a substance.	60	4.66637781629116	8	1.71439182915506	0.0923594091556725
sulfur metabolism	GO:0006790	The chemical reactions and physical changes involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.	36	2.7998266897747	4	1.42865985762922	0.306053230203843
vitamin metabolism	GO:0006766	The chemical reactions and physical changes involving vitamins, organic substances needed for the normal nutrition of an organism.	33	2.56650779896014	3	1.16890351987845	0.478919481760808
fat-soluble vitamin metabolism	GO:0006775	The chemical reactions and physical changes involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water.	5	0.388864818024263	0	0	1
vitamin A metabolism	GO:0006776	The chemical reactions and physical changes involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene.	5	0.388864818024263	0	0	1
water-soluble vitamin metabolism	GO:0006767	The chemical reactions and physical changes involving any of a diverse group of vitamins that are soluble in water.	23	1.78877816291161	3	1.67712244156473	0.263877345481983
xenobiotic metabolism	GO:0006805	The chemical reactions and physical changes involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.	49	3.81087521663778	0	0	1
organismal physiological process	GO:0050874	The processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.	1825	141.935658578856	113	0.796135383676117	0.995970073002375
bone remodeling	GO:0046849	The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.	29	2.25541594454073	2	0.886754394390549	0.670720342034218
regulation of bone remodeling	GO:0046850	Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.	6	0.466637781629116	0	0	1
circulation	GO:0008015	The flow of blood through the body of an animal, enabling the transport of O2 and nutrients to the tissues and the removal of waste products.	143	11.1215337954939	7	0.629409587626858	0.934043544548774
regulation of blood pressure	GO:0008217	Any process that modulates blood pressure.	36	2.7998266897747	2	0.714329928814609	0.781169733771809
regulation of blood vessel size	GO:0050880	Any process that modulates the size of blood vessels.	10	0.777729636048527	1	1.2857938718663	0.554981054514678
vasoconstriction	GO:0042310	A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
regulation of vasoconstriction	GO:0019229	Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.	6	0.466637781629116	1	2.14298978644383	0.384784738770702
regulation of heart rate	GO:0008016	Any process that modulates the frequency, rate or extent of heart contraction.	38	2.9553726169844	3	1.0151004251576	0.575551064817616
digestion	GO:0007586	The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.	52	4.04419410745234	2	0.49453610456396	0.920058204984164
excretion	GO:0007588	The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.	49	3.81087521663778	2	0.524813825251549	0.902867920107407
fluid secretion	GO:0007589	The regulated release of a fluid by a cell or group of cells.	8	0.622183708838821	1	1.60724233983287	0.476757755147065
immune response	GO:0006955	Any process involved in the immunological reaction of an organism to an immunogenic stimulus.	816	63.4627383015598	25	0.393931946037468	0.999999995443312
acute-phase response	GO:0006953	Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.	31	2.41096187175043	3	1.24431665019319	0.437451349268559
antigen presentation	GO:0019882	The process by which antigen-presenting cells express antigen (protein/peptide/lipid) on their cell surface in a form recognizable by lymphocytes.	54	4.19974003466205	4	0.952439905086145	0.613572742784165
antigen presentation, endogenous antigen	GO:0019883	The process by which antigen-presenting cells express self antigen on their cell surface in a form recognizable by lymphocytes.	29	2.25541594454073	4	1.7735087887811	0.185356447409555
antigen presentation, exogenous antigen	GO:0019884	The process by which antigen-presenting cells express foreign antigen on their cell surface in a form recognizable by lymphocytes.	21	1.63323223570191	0	0	1
antigen processing	GO:0030333	The processes that result in the fragmentation by proteolysis of antigens and the association of the resulting peptides with MHC molecules.	54	4.19974003466205	4	0.952439905086145	0.613572742784165
antigen processing, endogenous antigen via MHC class I	GO:0019885	The processes that result in the fragmentation by proteolysis of endogenous antigens and the association of the resulting peptides with MHC class I molecules.	28	2.17764298093588	4	1.83684838838042	0.169521933438873
antigen processing, exogenous antigen via MHC class II	GO:0019886	The processes that result in the fragmentation by proteolysis of exogenous antigens and the association of the resulting peptides with MHC class II molecules.	22	1.71100519930676	0	0	1
cytokine production	GO:0001816	The synthesis and release of a cytokine following a stimulus, resulting in an increase in its intracellular or extracellular levels.	32	2.48873483535529	0	0	1
regulation of cytokine production	GO:0001817	Any process that modulates the frequency, rate, or extent of production of a cytokine.	26	2.02209705372617	0	0	1
negative regulation of cytokine production	GO:0001818	Any process that stops, prevents, or reduces the rate of production of a cytokine.	6	0.466637781629116	0	0	1
positive regulation of cytokine production	GO:0001819	Any process that activates or increases the rate of production of a cytokine.	19	1.4776863084922	0	0	1
humoral immune response	GO:0006959	An immune response mediated through a body fluid.	184	14.3102253032929	5	0.349400508659319	0.998953784128464
antimicrobial humoral response	GO:0019730	An immune response against microbes mediated through a body fluid.	94	7.31065857885615	4	0.547146328453743	0.940377926683789
antimicrobial humoral response (sensu Vertebrata)	GO:0019735	An immune response against microbes mediated through a body fluid, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742).	94	7.31065857885615	4	0.547146328453743	0.940377926683789
complement activation	GO:0006956	Processes involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.	42	3.26646447140381	0	0	1
complement activation, alternative pathway	GO:0006957	Processes involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.	11	0.855502599653379	0	0	1
complement activation, classical pathway	GO:0006958	Processes involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.	37	2.87759965337955	0	0	1
humoral defense mechanism (sensu Vertebrata)	GO:0016064	The specific immune response mediated by antibodies, as in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742).	132	10.2660311958406	4	0.38963450662615	0.993187843762048
T-helper 2 type immune response	GO:0042092		10	0.777729636048527	0	0	1
innate immune response	GO:0045087	The innate immune response is the first line of defense against infection. It can also activate the adaptive immune response via inflammation as a danger signal that something has damaged the host tissue.	176	13.6880415944541	3	0.219169409977209	0.999918784937228
inflammatory response	GO:0006954	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.	170	13.221403812825	3	0.226904800917582	0.999876272985753
regulation of inflammatory response	GO:0050727	Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.	4	0.311091854419411	0	0	1
regulation of innate immune response	GO:0045088	Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.	6	0.466637781629116	0	0	1
regulation of immune response	GO:0050776	Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.	8	0.622183708838821	0	0	1
neurophysiological process	GO:0050877	The processes pertaining to the functions of the nervous system of an organism.	650	50.5524263431542	73	1.44404542532676	0.00113438725274207
neuromuscular physiological process	GO:0050905	The processes pertaining to the functions of the nervous and muscular systems of an organism.	312	24.265164644714	53	2.18420112849082	7.10222653661843e-08
sensory perception	GO:0007600	The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal.	350	27.2205372616984	21	0.771476323119777	0.91438373290963
equilibrioception	GO:0050957	The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion.	175	13.6102686308492	11	0.808213290887386	0.807772019682769
visual perception	GO:0007601	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.	175	13.6102686308492	11	0.808213290887386	0.807772019682769
sensory perception of chemical stimulus	GO:0007606	The series of events required to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal.	61	4.74415077989601	7	1.47550116443673	0.19423481232095
perception of smell	GO:0007608	The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors.	50	3.88864818024263	7	1.80011142061281	0.090912283845584
perception of taste	GO:0050909	The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells.	10	0.777729636048527	0	0	1
sensory perception of light	GO:0050953	The series of events required to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal.	175	13.6102686308492	11	0.808213290887386	0.807772019682769
sensory perception of mechanical stimulus	GO:0050954	The series of events required to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal.	118	9.17720970537262	3	0.326896747084651	0.995740713595278
perception of sound	GO:0007605	The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.	118	9.17720970537262	3	0.326896747084651	0.995740713595278
organismal movement	GO:0050879	Physiological processes involved in the relocation of an organism or an anatomical part of an organism.	484	37.6421143847487	64	1.70022330164138	2.57126678936183e-05
musculoskeletal movement	GO:0050881	The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.	175	13.6102686308492	11	0.808213290887386	0.807772019682769
regulation of balance	GO:0050885	The processes that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.	175	13.6102686308492	11	0.808213290887386	0.807772019682769
regulation of body fluids	GO:0050878	Any process that modulates the levels of body fluids.	140	10.8882149046794	7	0.642896935933148	0.924978722738294
hemostasis	GO:0007599	The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.	132	10.2660311958406	6	0.584451759939225	0.949105861197046
reproductive physiological process	GO:0050876	The processes pertinent to the reproductive function of an organism.	75	5.83297227036395	4	0.685756731662024	0.844217393420584
lactation	GO:0007595	The secretion of milk by the mammary gland.	9	0.699956672443674	0	0	1
parturition	GO:0007567	The process of giving birth to offspring.	8	0.622183708838821	1	1.60724233983287	0.476757755147065
pregnancy	GO:0007565	The physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.	68	5.28856152512998	4	0.756349336391938	0.784628384343977
respiratory gaseous exchange	GO:0007585	The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.	29	2.25541594454073	2	0.886754394390549	0.670720342034218
pathogenesis	GO:0009405	The specific processes that generate the ability of an organism to cause disease in another.	69	5.36633448873483	2	0.372693875903274	0.974442102959161
regulation of physiological process	GO:0050791	Any process that modulates the frequency, rate or extent of a physiological process, a processes specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms.	1801	140.06910745234	84	0.599703971331309	0.999999953401913
negative regulation of physiological process	GO:0043118	Any process that stops, prevents or reduces the rate of a physiological process, a process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms.	23	1.78877816291161	1	0.559040813854911	0.844664560448951
negative regulation of secretion	GO:0051048	Any process that stops, prevents or reduces the rate of the regulated release of a substance from a cell or group of cells.	6	0.466637781629116	0	0	1
positive regulation of physiological process	GO:0043119	Any process that activates or increases the rate of a physiological process, a process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
positive regulation of secretion	GO:0051047	Any process that activates or increases the rate of the regulated release of a substance from a cell or group of cells.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
regulation of secretion	GO:0051046	Any process that modulates the frequency, rate or extent of the regulated release of a substance from a cell or group of cells.	12	0.933275563258232	1	1.07149489322191	0.621510182350567
response to stimulus	GO:0050896	A change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a stimulus.	1749	136.024913344887	106	0.7792690132523	0.997566947126628
response to endogenous stimulus	GO:0009719	A change in state or activity of a cell or an organism as a result of the perception of an endogenous stimulus.	230	17.8877816291161	19	1.06217754632433	0.426767673896012
response to DNA damage stimulus	GO:0006974	A change in the state or activity of a cell (in terms of enzyme production, gene expression, etc.) as a result of damage to its DNA from environmental insults or errors during metabolism.	225	17.4989168110919	19	1.0857814917982	0.388989404761288
DNA damage response, signal transduction	GO:0042770	A cascade of processes induced by the detection of DNA damage within a cell.	20	1.55545927209705	0	0	1
response to hormone stimulus	GO:0009725	A change in state or activity of a cell or an organism as a result of the perception of a hormone.	3	0.233318890814558	0	0	1
response to external stimulus	GO:0009605	A change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of an external stimulus.	1478	114.948440207972	78	0.678565101526191	0.999937022835982
detection of external stimulus	GO:0009581	The series of events by which an external stimulus is received and converted into a molecular signal.	383	29.7870450606586	27	0.906434322203394	0.729281762711115
detection of abiotic stimulus	GO:0009582	The series of events by which an (non-living) abiotic stimulus is received and converted into a molecular signal.	154	11.9770363951473	8	0.667944868501972	0.918138937926535
detection of chemical substance	GO:0009593	The series of events by which a chemical stimulus is received and converted into a molecular signal.	7	0.544410745233969	2	3.67369677676084	0.0977020540462852
detection of light	GO:0009583	The series of events by which a light stimulus (in the form of photons) is received and converted into a molecular signal.	23	1.78877816291161	2	1.11808162770982	0.543371460995577
detection of visible light	GO:0009584	The series of events by which a visible light stimulus is received and converted into a molecular signal; visible light is defined as having a wavelength within the range 380-780 nm.	8	0.622183708838821	2	3.21448467966574	0.12375053710205
phototransduction, visible light	GO:0007603	The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal; visible light being defined as having a wavelength within the range 380-780 nm.	7	0.544410745233969	2	3.67369677676084	0.0977020540462852
phototransduction	GO:0007602	The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.	22	1.71100519930676	2	1.16890351987845	0.51906762486396
detection of mechanical stimulus	GO:0050982	The series of events by which a mechanical stimulus is received and converted into a molecular signal.	120	9.33275563258232	3	0.321448467966574	0.996265601194792
detection of biotic stimulus	GO:0009595	The series of events by which a biotic (living) stimulus is received and converted into a molecular signal.	16	1.24436741767764	1	0.803621169916435	0.726217553201261
detection of pest/pathogen/parasite	GO:0009596	The series of events by which a stimulus from a pest, pathogen or parasite is received and converted into a molecular signal.	16	1.24436741767764	1	0.803621169916435	0.726217553201261
detection of bacteria	GO:0016045	The series of events by which a stimulus from a bacterium is received and converted into a molecular signal.	4	0.311091854419411	0	0	1
response to abiotic stimulus	GO:0009628	A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of an abiotic (non-living) stimulus.	395	30.7203206239168	26	0.846345333380346	0.836629754942048
response to chemical substance	GO:0042221	A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a chemical substance.	199	15.4768197573657	14	0.904578603323022	0.689853026999564
chemotaxis	GO:0006935	The directed movement of a motile cell or organism in response to a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).	88	6.84402079722704	6	0.876677639908838	0.688913667325669
response to drug	GO:0042493	A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to any drug, a substance used in the diagnosis, treatment or prevention of a disease.	17	1.3221403812825	3	2.26904800917581	0.141321308938586
response to inorganic substance	GO:0010035	A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to an inorganic substance.	6	0.466637781629116	1	2.14298978644383	0.384784738770702
response to organic substance	GO:0010033	A change in state or activity of an organism(in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to an organic substance.	15	1.16659445407279	1	0.85719591457753	0.703129017048866
response to toxin	GO:0009636	The process by which a toxin or poisonous compound or other is rendered harmless.	10	0.777729636048527	1	1.2857938718663	0.554981054514678
response to xenobiotic stimulus	GO:0009410	A change in state or activity of an organism as the result of exposure to a xenobiotic compound, a compound foreign to living organisms.	51	3.96642114384749	1	0.252116445463979	0.983903540859625
response to radiation	GO:0009314	A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of radiation.	42	3.26646447140381	3	0.918424194190211	0.644238037684352
response to light	GO:0009416	A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a light stimulus.	30	2.33318890814558	3	1.2857938718663	0.416246509111854
response to temperature	GO:0009266	A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of temperature.	20	1.55545927209705	2	1.2857938718663	0.467934044192153
response to cold	GO:0009409	A change in state or activity of an organism (in terms of movement, secretion, gene expression, enzyme production, etc.) in response to temperatures below the optimal temperature for that organism.	6	0.466637781629116	0	0	1
response to heat	GO:0009408	A change in state or activity of an organism (in terms of movement, secretion, gene expression, enzyme production, etc.) in response to temperatures above the optimal temperature for that organism.	11	0.855502599653379	2	2.3378070397569	0.20887663200768
response to biotic stimulus	GO:0009607	A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a biotic stimulus.	948	73.7287694974003	32	0.434023247887357	0.999999994518921
defense response	GO:0006952	Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.	883	68.6735268630849	27	0.393164604081427	0.999999998893733
defense response to bacteria	GO:0042742	Reactions triggered in response to the presence of bacteria that act to protect the cell or organism.	10	0.777729636048527	0	0	1
defense response to Gram-positive bacteria	GO:0050830	Reactions triggered in response to the presence of Gram-positive bacteria that act to protect the cell or organism.	0	0	0	0	1
defense response to fungi	GO:0050832	Reactions triggered in response to the presence of fungi that act to protect the cell or organism.	10	0.777729636048527	0	0	1
response to bacteria	GO:0009617	A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of bacteria.	29	2.25541594454073	1	0.443377197195274	0.904435266978434
response to pathogenic bacteria	GO:0009618	A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a pathogenic (disease-causing) bacteria.	15	1.16659445407279	1	0.85719591457753	0.703129017048866
response to fungi	GO:0009620	A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of fungi.	11	0.855502599653379	0	0	1
response to pest/pathogen/parasite	GO:0009613	A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a pest, a pathogen or a parasite.	480	37.3310225303293	19	0.508960074280409	0.999771534999188
response to virus	GO:0009615	A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a virus.	30	2.33318890814558	3	1.2857938718663	0.416246509111854
response to unfolded protein	GO:0006986	A change in the state or activity of a cell (in terms of enzyme production, gene expression, etc.) as a result of the presence of unfolded proteins.	5	0.388864818024263	0	0	1
response to wounding	GO:0009611	A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of damage to the organism.	282	21.9319757365685	12	0.547146328453743	0.993788409582024
taxis	GO:0042330	The directed movement of a cell or organism in response to an external stimulus.	88	6.84402079722704	6	0.876677639908838	0.688913667325669
response to stress	GO:0006950	A change in state or activity of an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) that occurs in response to stress, usually, but not necessarily exogenous (e.g. temperature, humidity, ionizing radiation).	853	66.3403379549393	57	0.859205752595297	0.89794155198401
response to hypoxia	GO:0001666	The alteration of cellular processes due to exposure to lowered oxygen tension.	3	0.233318890814558	1	4.28597957288765	0.215643409392579
secretion	GO:0046903	The regulated release of a substance by a cell or group of cells.	83	6.45515597920277	20	3.09829848642481	4.34494852928819e-06
protein secretion	GO:0009306	The regulated release of proteins from a cell or group of cells.	25	1.94432409012132	3	1.54295264623955	0.307483370901745
regulation of biological process	GO:0050789	Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.	2645	205.709488734835	152	0.738906119182143	0.999979713637961
regulation of enzyme activity	GO:0050790	Any process that modulates the activity of an enzyme.	118	9.17720970537262	19	2.07034606486946	0.00192398387805161
negative regulation of enzyme activity	GO:0043086	Any process that stops or reduces the activity of an enzyme.	33	2.56650779896014	4	1.5585380265046	0.252717811283259
positive regulation of enzyme activity	GO:0043085	Any process that activates or increases the activity of an enzyme.	35	2.72205372616984	9	3.30632709908476	0.00113698926720772
regulation of viral life cycle	GO:0050792	Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts.	9	0.699956672443674	2	2.85731971525843	0.151204954623315
viral life cycle	GO:0016032	A set of processes by which a virus reproduces. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle; see viral infectious cycle (GO:0019058) and its children, and lysogeny (GO:0030069).	38	2.9553726169844	3	1.0151004251576	0.575551064817616
viral infectious cycle	GO:0019058	A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.	36	2.7998266897747	3	1.07149489322191	0.538237721637986
initiation of viral infection	GO:0019059	Processes involved in the start of virus infection of cells.	11	0.855502599653379	0	0	1
viral entry	GO:0046718	The process by which a virion enters a host cell, including virion attachment and penetration.	11	0.855502599653379	0	0	1
viral genome replication	GO:0019079	Any process involved directly in viral genome replication, including viral nucleotide metabolism.	29	2.25541594454073	3	1.33013159158582	0.394786300979571
biological_process	GO:0008150	A phenomenon marked by changes that lead to a particular result, mediated by one or more gene products.	10151	789.47335355286	857	1.08553378799075	0.00698352170642899
behavior	GO:0007610	The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.	117	9.09943674176776	8	0.879175297002595	0.697388553012425
feeding behavior	GO:0007631	Behavior (GO:0007610) associated with the intake of food.	23	1.78877816291161	1	0.559040813854911	0.844664560448951
learning and/or memory	GO:0007611	The acquisition and processing of information and/or the storage and retrieval of this information over time.	31	2.41096187175043	4	1.65908886692425	0.218334667649271
locomotory behavior	GO:0007626	The abilities associated with normal movement, including both general motion and specifically coordinated patterns of activity.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
mechanosensory behavior	GO:0007638	Behavior that is dependent upon the sensation of movement.	8	0.622183708838821	0	0	1
rhythmic behavior	GO:0007622	The specific actions or reactions of an organism that recur with measured regularity.	27	2.09987001733102	0	0	1
circadian rhythm	GO:0007623	The specific actions or reactions of an organism that recur with a regularity of approximately 24 hours.	18	1.39991334488735	0	0	1
biological_process unknown	GO:0000004	Used for the annotation of gene products whose process is not known or cannot be inferred.	378	29.3981802426343	29	0.986455615982078	0.55803786630448
cellular process	GO:0009987	Processes that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.	6155	478.692590987868	508	1.06122386175155	0.0860628689172938
cell communication	GO:0007154	Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.	3263	253.773180242634	268	1.05606116353101	0.184287121804664
cell adhesion	GO:0007155	The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules.	663	51.5634748700173	40	0.775742909119937	0.963871717725154
cell recognition	GO:0008037	The process by which a cell in a multicellular organism interprets its surroundings.	18	1.39991334488735	2	1.42865985762922	0.4136837631352
cell-cell adhesion	GO:0016337	The attachment of one cell to another cell via adhesion molecules.	260	20.2209705372617	17	0.840711377758732	0.803401279036373
calcium-dependent cell-cell adhesion	GO:0016339	The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.	7	0.544410745233969	0	0	1
heterophilic cell adhesion	GO:0007157	The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.	111	8.63279896013865	5	0.579186428768602	0.938771407080847
leukocyte cell adhesion	GO:0007159	The attachment of an adhesion molecule on a leukocyte cell to a nonidentical adhesion molecule in an adjacent cell.	13	1.01104852686308	0	0	1
homophilic cell adhesion	GO:0007156	The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell.	113	8.78834488734835	12	1.36544481968102	0.168541890499735
cell-matrix adhesion	GO:0007160	The binding of a cell to the extracellular matrix via adhesion molecules.	83	6.45515597920277	0	0	1
regulation of cell adhesion	GO:0030155	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.	37	2.87759965337955	1	0.347511857261161	0.949996494565024
negative regulation of cell adhesion	GO:0007162	Any process that stops, prevents or reduces the rate of cell adhesion.	21	1.63323223570191	0	0	1
cell-cell signaling	GO:0007267	Any process that mediates the transfer of information from one cell to another.	628	48.8414211438475	64	1.31036318151979	0.0172137468352335
hormone secretion	GO:0046879	The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.	9	0.699956672443674	0	0	1
regulation of hormone secretion	GO:0046883	Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells.	6	0.466637781629116	0	0	1
negative regulation of hormone secretion	GO:0046888	Any process that stops, prevents or reduces the rate of the regulated release of hormones.	6	0.466637781629116	0	0	1
transmission of nerve impulse	GO:0019226	The sequential, electrochemical polarization and depolarisation that travels across the membrane of a nerve cell (neuron) in response to stimulation.	312	24.265164644714	53	2.18420112849082	7.10222653661843e-08
synaptic transmission	GO:0007268	The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.	306	23.7985268630849	52	2.18500919402116	9.24834431331859e-08
nerve-nerve synaptic transmission	GO:0007270	The process of communication from a neuron to another neuron across a synapse.	22	1.71100519930676	4	2.3378070397569	0.0867867307554927
synaptic transmission, cholinergic	GO:0007271		18	1.39991334488735	1	0.714329928814609	0.767147287962174
regulation of neurotransmitter levels	GO:0001505	Any process that modulates levels of neurotransmitter.	66	5.13301559792028	22	4.28597957288765	2.43801031854841e-09
neurotransmitter metabolism	GO:0042133	The chemical reactions and physical changes involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.	22	1.71100519930676	5	2.92225879969613	0.0244692017194864
neurotransmitter biosynthesis	GO:0042136	The formation from simpler components of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.	8	0.622183708838821	2	3.21448467966574	0.12375053710205
neurotransmitter catabolism	GO:0042135	The breakdown into simpler components of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.	11	0.855502599653379	2	2.3378070397569	0.20887663200768
neurotransmitter secretion	GO:0007269	The regulated release of neurotransmitter into the synaptic cleft.	36	2.7998266897747	15	5.35747446610956	2.6302131078363e-08
synaptic vesicle endocytosis	GO:0008099	Endocytosis of a synaptic vesicle into the presynaptic or postsynaptic membrane.	14	1.08882149046794	5	4.59212097095105	0.00313268177521419
synaptic vesicle exocytosis	GO:0016079	Exocytosis of a synaptic vesicle from the presynaptic membrane.	9	0.699956672443674	5	7.14329928814609	0.000274455837958301
synaptic vesicle transport	GO:0016181	Transport of vesicles containing neurotransmitters back and forth across the synapse.	24	1.86655112651646	10	5.35747446610956	5.71445135328376e-06
response to extracellular stimulus	GO:0009991	A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of an extracellular stimulus.	20	1.55545927209705	2	1.2857938718663	0.467934044192153
response to nutrients	GO:0007584	A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of nutrients.	19	1.4776863084922	2	1.35346723354347	0.441173668987211
signal transduction	GO:0007165	The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the cell's functioning.	2578	200.49870017331	201	1.0025002647212	0.49583019552363
cell surface receptor linked signal transduction	GO:0007166	Any pathway of signal transduction initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.	1135	88.2723136915078	81	0.917615009878149	0.80443069360008
cytokine and chemokine mediated signaling pathway	GO:0019221		6	0.466637781629116	0	0	1
enzyme linked receptor protein signaling pathway	GO:0007167	Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase.	206	16.0212305025997	16	0.998674851934987	0.539482480900685
transmembrane receptor protein serine/threonine kinase signaling pathway	GO:0007178	The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.	39	3.03314558058925	1	0.329690736375973	0.957471883285156
transforming growth factor beta receptor signaling pathway	GO:0007179	The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands.	25	1.94432409012132	1	0.514317548746518	0.867886788221895
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand.	145	11.2770797227036	11	0.975429833829603	0.578785050138488
epidermal growth factor receptor signaling pathway	GO:0007173	The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.	23	1.78877816291161	2	1.11808162770982	0.543371460995577
fibroblast growth factor receptor signaling pathway	GO:0008543	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.	14	1.08882149046794	2	1.83684838838042	0.298036386882161
insulin receptor signaling pathway	GO:0008286	The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	13	1.01104852686308	1	0.989072209127919	0.650946457163423
signal complex formation	GO:0007172	Formation of a complex by dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors; the resulting complex is capable of relaying a signal within a cell.	11	0.855502599653379	1	1.16890351987845	0.589591496765378
transmembrane receptor protein tyrosine phosphatase signaling pathway	GO:0007185	The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine phosphatase binding to its physiological ligand.	16	1.24436741767764	2	1.60724233983287	0.356800974762934
G-protein coupled receptor protein signaling pathway	GO:0007186	The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.	615	47.8303726169844	51	1.06626808886473	0.337379260931798
acetyl choline receptor signaling, muscarinic pathway	GO:0007213		6	0.466637781629116	2	4.28597957288765	0.0734918863657436
dopamine receptor signaling pathway	GO:0007212		9	0.699956672443674	1	1.42865985762922	0.517451855212534
G-protein signaling, coupled to cyclic nucleotide second messenger	GO:0007187		137	10.6548960138648	15	1.40780350934266	0.113093953859912
G-protein signaling, coupled to cAMP nucleotide second messenger	GO:0007188		91	7.07733968804159	13	1.83684838838042	0.0237780545822547
G-protein signaling, adenylate cyclase activating pathway	GO:0007189		35	2.72205372616984	9	3.30632709908476	0.00113698926720772
adenylate cyclase activation	GO:0007190		33	2.56650779896014	9	3.50671055963535	0.000715751838133224
G-protein signaling, adenylate cyclase inhibiting pathway	GO:0007193		73	5.67742634315425	12	2.11363376197199	0.0103591814897376
regulation of adenylate cyclase activity	GO:0045761	Any process that modulates the frequency, rate or extent of adenylate cyclase activity.	55	4.2775129982669	12	2.80536844770828	0.000905511493973702
negative regulation of adenylate cyclase activity	GO:0007194	Any process that stops, prevents or reduces the rate of adenylate cyclase activity.	22	1.71100519930676	3	1.75335527981768	0.242356718209695
positive regulation of adenylate cyclase activity	GO:0045762	Any process that activates or increases the rate of adenylate cyclase activity.	33	2.56650779896014	9	3.50671055963535	0.000715751838133224
G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)	GO:0007200		101	7.85506932409012	5	0.63653161973579	0.901138472752979
cytosolic calcium ion concentration elevation	GO:0007204		47	3.65532928942808	0	0	1
phospholipase C activation	GO:0007202	A signaling pathway that leads to the upregulation of phospholipase C activity in response to the signal.	22	1.71100519930676	0	0	1
protein kinase C activation	GO:0007205		26	2.02209705372617	3	1.48360831369188	0.32940524860957
gamma-aminobutyric acid signaling pathway	GO:0007214		13	1.01104852686308	2	1.97814441825584	0.268274884596286
glutamate signaling pathway	GO:0007215		18	1.39991334488735	2	1.42865985762922	0.4136837631352
neuropeptide signaling pathway	GO:0007218		65	5.05524263431542	7	1.38470109277909	0.240087373825404
regulation of G-protein coupled receptor protein signaling pathway	GO:0008277	Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.	38	2.9553726169844	6	2.0302008503152	0.071338845551476
tachykinin signaling pathway	GO:0007217		7	0.544410745233969	1	1.83684838838042	0.432631852891438
integrin-mediated signaling pathway	GO:0007229		58	4.51083188908146	0	0	1
Notch signaling pathway	GO:0007219	A pathway of signal transduction initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell.	17	1.3221403812825	0	0	1
Wnt receptor signaling pathway	GO:0016055	A pathway of signal transduction initiated by binding of Wnt protein to a receptor on the surface of the target cell.	104	8.08838821490468	6	0.74180415684594	0.827700074687599
frizzled signaling pathway	GO:0007222	A pathway of signal transduction initiated by binding of Wnt protein to a frizzled receptor on the surface of the target cell.	21	1.63323223570191	0	0	1
frizzled-2 signaling pathway	GO:0007223	A pathway of signal transduction initiated by binding of Wnt protein to a frizzled-2 receptor on the surface of the target cell.	19	1.4776863084922	0	0	1
regulation of Wnt receptor signaling pathway	GO:0030111	Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signal transduction pathway.	16	1.24436741767764	1	0.803621169916435	0.726217553201261
negative regulation of Wnt receptor signaling pathway	GO:0030178	Any process that stops, prevents or reduces the rate of Wnt receptor signaling pathway activity.	7	0.544410745233969	0	0	1
intracellular signaling cascade	GO:0007242	A series of reactions within the cell that occur as a result of a single trigger reaction or compound.	983	76.4508232235702	87	1.13798643796915	0.116941149511845
intracellular receptor-mediated signaling pathway	GO:0030522	A signaling pathway initiated by a ligand entering the target cell, where it binds to an intracellular receptor.	33	2.56650779896014	2	0.7792690132523	0.738495502397773
steroid hormone receptor signaling pathway	GO:0030518	Signal transduction pathway mediated by a steroid hormone and its receptor.	33	2.56650779896014	2	0.7792690132523	0.738495502397773
androgen receptor signaling pathway	GO:0030521	Signal transduction pathway mediated by an androgen and its receptor.	18	1.39991334488735	2	1.42865985762922	0.4136837631352
estrogen receptor signaling pathway	GO:0030520	Signal transduction pathway mediated by an estrogen and its receptor.	19	1.4776863084922	0	0	1
nitric oxide mediated signal transduction	GO:0007263	Signal transduction pathway mediated by the perception of nitric oxide (NO).	6	0.466637781629116	1	2.14298978644383	0.384784738770702
protein kinase cascade	GO:0007243	A series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.	288	22.3986135181976	21	0.937558031569174	0.652340746022802
I-kappaB kinase/NF-kappaB cascade	GO:0007249	A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.	115	8.94389081455806	3	0.335424488312947	0.994816414656232
activation of NF-kappaB-inducing kinase	GO:0007250	The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.	15	1.16659445407279	0	0	1
regulation of I-kappaB kinase/NF-kappaB cascade	GO:0043122	Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade.	87	6.76624783362218	1	0.147792399065091	0.99912724378017
positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:0043123	Any process that activates or increases the rate of an I-kappaB kinase/NF-kappaB induced cascade.	87	6.76624783362218	1	0.147792399065091	0.99912724378017
JAK-STAT cascade	GO:0007259	The processes by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.	44	3.42201039861352	5	1.46112939984806	0.255346447029199
regulation of JAK-STAT cascade	GO:0046425	Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
negative regulation of JAK-STAT cascade	GO:0046426	Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
regulation of tyrosine phosphorylation of STAT protein	GO:0042509	Any process that modulates the frequency, rate or extent of the introduction of a phosphoric group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
regulation of tyrosine phosphorylation of Stat3 protein	GO:0042516	Any process that modulates the frequency, rate or extent of introducing a phosphoric group to a tyrosine residue of a Stat3 protein.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
tyrosine phosphorylation of STAT protein	GO:0007260	The process of introducing a phosphoric group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.	17	1.3221403812825	2	1.51269867278388	0.385531596872848
tyrosine phosphorylation of Stat3 protein	GO:0042503	The process of introducing a phosphoric group to a tyrosine residue of a Stat3 protein.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
JNK cascade	GO:0007254	A cascade of protein kinase activities, culminating in the phosphorylation and activation of a JUN kinase, a member of a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress.	42	3.26646447140381	5	1.53070699031702	0.225725837857596
activation of JUNK	GO:0007257	Upregulation of a JUN kinase activity due to phosphorylation by a JUN kinase kinase (JNKK).	10	0.777729636048527	0	0	1
regulation of JNK cascade	GO:0046328	Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
MAPKKK cascade	GO:0000165	Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.	64	4.97746967071057	8	1.60724233983287	0.122426153786431
activation of MAPK	GO:0000187	Upregulation of a MAP kinase activity due to phosphorylation by a MAPKK.	19	1.4776863084922	2	1.35346723354347	0.441173668987211
inactivation of MAPK	GO:0000188	Downregulation of MAP kinase activity.	23	1.78877816291161	5	2.79520406927456	0.029315820637148
second-messenger-mediated signaling	GO:0019932		153	11.8992634315425	17	1.42865985762922	0.0872256679291357
calcium-mediated signaling	GO:0019722	The process by which a cell uses calcium ions to convert an extracellular signal into a response.	6	0.466637781629116	1	2.14298978644383	0.384784738770702
cyclic-nucleotide-mediated signaling	GO:0019935	The process by which a cell uses a cyclic nucleotide to convert an extracellular signal into a response.	137	10.6548960138648	15	1.40780350934266	0.113093953859912
cAMP-mediated signaling	GO:0019933		91	7.07733968804159	13	1.83684838838042	0.0237780545822547
small GTPase mediated signal transduction	GO:0007264		217	16.876733102253	22	1.30356982401191	0.122615710515147
RAS protein signal transduction	GO:0007265	A series of reactions within the cell that are mediated by a member of the RAS family of proteins switching to a GTP-bound active state.	43	3.34423743500867	3	0.897065491999741	0.660123618485486
Rho protein signal transduction	GO:0007266	A series of reactions within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.	27	2.09987001733102	0	0	1
regulation of signal transduction	GO:0009966	Any process that modulates the frequency, rate or extent of signal transduction.	174	13.5324956672444	10	0.738961995325457	0.876612204262428
negative regulation of signal transduction	GO:0009968	Any process that stops, prevents or reduces the rate of signal transduction.	26	2.02209705372617	1	0.49453610456396	0.878161624233234
positive regulation of signal transduction	GO:0009967	Any process that activates or increases the rate of signal transduction.	89	6.92179376083189	1	0.144471221558011	0.999257718472782
two-component signal transduction system (phosphorelay)	GO:0000160	A conserved signal transduction system found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase that then acts as a phospho-donor to response regulator proteins; also known as histidyl-aspartyl phosphorelay.	5	0.388864818024263	0	0	1
cell differentiation	GO:0030154	The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.	237	18.4321923743501	13	0.705287777816955	0.931141700180241
cell development	GO:0048468	Processes by which a cell becomes a fully functional differentiated cell, following commitment to a specific fate.	19	1.4776863084922	1	0.676733616771734	0.785256933460783
cell maturation	GO:0048469	Processes by which a cell attains its full functional capacity. These process are independent of morphogenetic change.	14	1.08882149046794	1	0.918424194190211	0.678093385646598
nerve maturation	GO:0042551	The processes leading to the attainment of full functional capacity of a nascent neuron.	14	1.08882149046794	1	0.918424194190211	0.678093385646598
nerve ensheathment	GO:0008366	The processes by which the axon of a neuron is insulated, thereby preventing dispersion of the electrical signal.	14	1.08882149046794	1	0.918424194190211	0.678093385646598
cell fate commitment	GO:0045165	The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.	25	1.94432409012132	1	0.514317548746518	0.867886788221895
cell fate determination	GO:0001709	Process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.	24	1.86655112651646	1	0.535747446610956	0.856745457935699
hemocyte differentiation (sensu Arthropoda)	GO:0042386	The process whereby a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656).	11	0.855502599653379	0	0	1
hemocyte development	GO:0007516	Development of an immature hemocyte cell into a mature hemocyte, following its initial specification. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body). As in, but not restricted to, arthropods (Arthropoda, ncbi_taxonomy_id:6656).	8	0.622183708838821	0	0	1
keratinocyte differentiation	GO:0030216	The process whereby a relatively unspecialized cell acquires specialized features of a keratinocyte.	8	0.622183708838821	0	0	1
lymphocyte differentiation	GO:0030098	The process whereby a relatively unspecialized precursor cell acquires specialized features of B-cells, T-cells, or natural killer cells.	34	2.64428076256499	0	0	1
B-cell differentiation	GO:0030183	The process by which a hemopoietic stem cell acquires characteristics of a B-cell.	15	1.16659445407279	0	0	1
regulation of lymphocyte differentiation	GO:0045619	Any process that modulates the frequency, rate or extent of lymphocyte differentiation.	16	1.24436741767764	0	0	1
positive regulation of lymphocyte differentiation	GO:0045621	Any process that activates or increases the rate of lymphocyte differentiation.	9	0.699956672443674	0	0	1
positive regulation of T-cell differentiation	GO:0045582	Any process that activates or increases the rate of T-cell differentiation.	9	0.699956672443674	0	0	1
regulation of T-cell differentiation	GO:0045580	Any process that modulates the frequency, rate or extent of T-cell differentiation.	13	1.01104852686308	0	0	1
T-cell differentiation	GO:0030217	The process by which a hemopoietic stem cell acquires characteristics of a T-cell.	17	1.3221403812825	0	0	1
T-helper cell differentiation	GO:0042093	The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell.	11	0.855502599653379	0	0	1
myeloid blood cell differentiation	GO:0030099	Differentiation of erythrocytes, megakaryocytes, platelets, basophils, eosinophils, neutrophils, monocytes, macrophages, and osteoclasts from myeloid precursor cells.	20	1.55545927209705	0	0	1
monocyte differentiation	GO:0030224	The process by which a myeloid precursor cell acquires specializes features of a monocyte.	15	1.16659445407279	0	0	1
regulation of monocyte differentiation	GO:0045655	Any process that modulates the frequency, rate or extent of monocyte differentiation.	6	0.466637781629116	0	0	1
regulation of myeloid blood cell differentiation	GO:0045637	Any process that modulates the frequency, rate or extent of myeloid blood cell differentiation.	8	0.622183708838821	0	0	1
negative regulation of myeloid blood cell differentiation	GO:0045638	Any process that stops, prevents or reduces the rate of myeloid blood cell differentiation.	6	0.466637781629116	0	0	1
myoblast differentiation	GO:0045445	The process whereby a relatively unspecialized cell acquires specialized features of a myoblast, a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.	9	0.699956672443674	0	0	1
neuron differentiation	GO:0030182	The process whereby a relatively unspecialized cell acquires specialized features of a neuron.	10	0.777729636048527	5	6.42896935933148	0.000513623819005561
regulation of neuron differentiation	GO:0045664	Any process that modulates the frequency, rate or extent of neuron differentiation.	5	0.388864818024263	2	5.14317548746518	0.0516153430227439
regulation of cell differentiation	GO:0045595	Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.	46	3.57755632582322	3	0.838561220782367	0.704659694796215
negative regulation of cell differentiation	GO:0045596	Any process that stops, prevents or reduces the rate of cell differentiation.	10	0.777729636048527	0	0	1
positive regulation of cell differentiation	GO:0045597	Any process that activates or increases the rate of cell differentiation.	15	1.16659445407279	0	0	1
spermatid development	GO:0007286	The process by which an immature germ cell becomes a mature male gamete.	8	0.622183708838821	2	3.21448467966574	0.12375053710205
cellular physiological process	GO:0050875	The processes pertinent to the integrated function of a cell.	4234	329.290727902946	353	1.07200103157488	0.0924361662840393
autophagy	GO:0006914	The process by which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of nutrient limitation and remodeling the intracellular structure for cell differentiation.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
cell activation	GO:0001775	A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.	90	6.99956672443674	0	0	1
immune cell activation	GO:0045321	A change in morphology and behavior of an immune cell resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, pathogen, or soluble factor.	90	6.99956672443674	0	0	1
lymphocyte activation	GO:0046649	A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.	74	5.7551993067591	0	0	1
B-cell activation	GO:0042113	The change in morphology and behavior of a mature or immature B-cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.	30	2.33318890814558	0	0	1
B-cell proliferation	GO:0042100	The rapid expansion of a B-cell population by cell division. Follows B-cell activation.	9	0.699956672443674	0	0	1
lymphocyte proliferation	GO:0046651	The rapid expansion of a lymphocyte population by cell division.	21	1.63323223570191	0	0	1
regulation of lymphocyte proliferation	GO:0050670	Any process that modulates the frequency, rate or extent of lymphocyte proliferation.	13	1.01104852686308	0	0	1
positive regulation of lymphocyte proliferation	GO:0050671	Any process that activates or increases the rate or extent of lymphocyte proliferation.	11	0.855502599653379	0	0	1
positive regulation of T-cell proliferation	GO:0042102	Any process that activates or increases the rate or extent of T-cell proliferation.	10	0.777729636048527	0	0	1
regulation of T-cell proliferation	GO:0042129	Any process that modulates the frequency, rate or extent of T-cell proliferation.	12	0.933275563258232	0	0	1
T-cell proliferation	GO:0042098	The rapid expansion of a T-cell population by cell division. Follows T-cell activation.	13	1.01104852686308	0	0	1
natural killer cell activation	GO:0030101	The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, pathogen, or soluble factor.	8	0.622183708838821	0	0	1
T-cell activation	GO:0042110	The change in morphology and behavior of a mature or immature T-cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.	41	3.18869150779896	0	0	1
cell death	GO:0008219	The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.	525	40.8308058925477	30	0.734739355352169	0.972012442047901
cytolysis	GO:0019835	The rupture of cell membranes and the loss of cytoplasm.	14	1.08882149046794	3	2.75527258257063	0.0897058708810319
programmed cell death	GO:0012501	Cell death resulting from activation of endogenous cellular processes.	493	38.3420710571924	27	0.704187313192494	0.981002033993317
apoptosis	GO:0006915	A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposition of phosphatidylserine.	492	38.2642980935875	27	0.705618588219308	0.980426176612054
apoptotic program	GO:0008632	The genetically programmed processes that occur during apoptosis.	56	4.35528596187175	2	0.459212097095105	0.938551531506733
apoptotic nuclear changes	GO:0030262		5	0.388864818024263	0	0	1
DNA fragmentation	GO:0006309	Internucleosomal cleavage of chromatin that is characteristic of apoptosis.	5	0.388864818024263	0	0	1
caspase activation	GO:0006919	Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis.	26	2.02209705372617	1	0.49453610456396	0.878161624233234
regulation of caspase activation	GO:0043026	Any process that modulates the frequency, rate or extent of caspase activation.	4	0.311091854419411	0	0	1
negative regulation of caspase activation	GO:0043154	Any process that stops, prevents or reduces the rate of caspase activation.	4	0.311091854419411	0	0	1
inhibition of caspase activation	GO:0001719	Any process that results in preventing the activation of the pro-apoptotic caspases.	4	0.311091854419411	0	0	1
disassembly of cell structures	GO:0006921		5	0.388864818024263	0	0	1
regulation of apoptosis	GO:0042981	Any process that modulates the occurrence or rate of cell death by apoptosis.	319	24.809575389948	16	0.64491228682949	0.979729576113281
negative regulation of apoptosis	GO:0043066	Any process that stops, prevents or reduces the rate of cell death by apoptosis.	143	11.1215337954939	10	0.899156553752654	0.681694400055148
anti-apoptosis	GO:0006916	A process which directly inhibits any of the steps required for cell death by apoptosis.	138	10.7326689774697	8	0.745387751806548	0.849302632541372
regulation of anti-apoptosis	GO:0045767	Any process that modulates the frequency, rate or extent of anti-apoptosis.	12	0.933275563258232	4	4.28597957288765	0.0108899304991899
positive regulation of anti-apoptosis	GO:0045768	Any process that activates or increases the rate of anti-apoptosis.	9	0.699956672443674	3	4.28597957288765	0.0276600757776216
positive regulation of apoptosis	GO:0043065	Any process that activates or increases the rate of cell death by apoptosis.	165	12.8325389948007	6	0.46756140795138	0.990296947553882
induction of apoptosis	GO:0006917	A process that directly activates any of the steps required for cell death by apoptosis.	161	12.5214471403813	6	0.479177840447067	0.988018057910916
induction of apoptosis by extracellular signals	GO:0008624	Any process induced by extracellular signals that directly activates any of the steps required for cell death by apoptosis.	38	2.9553726169844	0	0	1
induction of apoptosis via death domain receptors	GO:0008625		9	0.699956672443674	0	0	1
induction of apoptosis by intracellular signals	GO:0008629	Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis.	20	1.55545927209705	3	1.92869080779944	0.200330292142734
DNA damage response, signal transduction resulting in induction of apoptosis	GO:0008630	A cascade of processes initiated by the perception of DNA damage and resulting in the induction of apoptosis (programmed cell death).	7	0.544410745233969	0	0	1
regulation of programmed cell death	GO:0043067	Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.	319	24.809575389948	16	0.64491228682949	0.979729576113281
negative regulation of programmed cell death	GO:0043069	Any process that stops, prevents or reduces the rate of programmed cell death, cell death resulting from activation of endogenous cellular processes.	143	11.1215337954939	10	0.899156553752654	0.681694400055148
positive regulation of programmed cell death	GO:0043068	Any process that activates or increases the rate of programmed cell death, cell death resulting from activation of endogenous cellular processes.	165	12.8325389948007	6	0.46756140795138	0.990296947553882
induction of programmed cell death	GO:0012502	A process which directly activates any of the steps required for programmed cell death.	161	12.5214471403813	6	0.479177840447067	0.988018057910916
cell growth and/or maintenance	GO:0008151	Any process required for the survival and growth of a cell.	3647	283.637998266898	319	1.12467300555346	0.0167692277189386
cell growth	GO:0016049	The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.	122	9.48830155979203	9	0.948536462852185	0.614219727188094
regulation of cell growth	GO:0001558	Any process that modulates the frequency, rate or extent of cell growth.	85	6.61070190641248	5	0.756349336391938	0.799687457984394
negative regulation of cell growth	GO:0030308	Any process that stops, prevents or reduces the rate of cell growth.	28	2.17764298093588	2	0.918424194190211	0.65169040816838
cell homeostasis	GO:0019725	Any of the processes involved in the maintenance of an internal equilibrium within a cell.	91	7.07733968804159	6	0.847776179252502	0.719574550896029
cell ion homeostasis	GO:0006873	The regulation of the levels, transport, and metabolism of ions within a cell or between a cell and its external environment.	84	6.53292894280762	6	0.918424194190211	0.644721637539678
cation homeostasis	GO:0030003	The regulation of the levels, transport, and metabolism of cations within a cell or between a cell and its external environment.	76	5.9107452339688	5	0.845917020964668	0.713486901971295
di-, tri-valent inorganic cation homeostasis	GO:0030005	The regulation of the levels, transport, and metabolism of divalent and trivalent inorganic cations within a cell or between a cell and its external environment.	59	4.58860485268631	3	0.653793494169303	0.847185625667374
calcium ion homeostasis	GO:0006874	The regulation of the levels, transport, and metabolism of calcium ions within a cell or between a cell and its external environment.	22	1.71100519930676	1	0.584451759939225	0.831564860472717
copper ion homeostasis	GO:0006878	The regulation of the levels, transport, and metabolism of copper ions within a cell or between a cell and its external environment.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
iron ion homeostasis	GO:0006879	The regulation of the levels, transport, and metabolism of iron ions within a cell or between a cell and its external environment.	32	2.48873483535529	1	0.401810584958217	0.925043171824896
metal ion homeostasis	GO:0006875	The regulation of the levels, transport, and metabolism of metal ions within a cell or between a cell and its external environment.	63	4.89969670710572	3	0.612282796126807	0.876920553501049
transition metal ion homeostasis	GO:0046916	The regulation of the levels, transport, and metabolism of transition metal ions within a cell or between a cell and its external environment. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.	37	2.87759965337955	2	0.695023714522322	0.79397193203442
monovalent inorganic cation homeostasis	GO:0030004	The regulation of the levels, transport, and metabolism of monovalent inorganic cations within a cell or between a cell and its external environment.	14	1.08882149046794	2	1.83684838838042	0.298036386882161
hydrogen ion homeostasis	GO:0030641	The regulation of the levels, transport, and metabolism of hydrogen ions (protons) within a cell or between a cell and its external environment.	13	1.01104852686308	2	1.97814441825584	0.268274884596286
regulation of pH	GO:0006885	Any process that modulates the pH of a solution, measured by the concentration of the hydrogen ion.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
regulation of cell volume	GO:0006884	Any process that modulates the volume of a cell.	7	0.544410745233969	0	0	1
cell organization and biogenesis	GO:0016043	The processes involved in the assembly and arrangement of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.	758	58.9519064124783	67	1.13651964927496	0.153065492790038
cellular morphogenesis	GO:0000902	Any process that modulates the mass, volume, or shape of a cell.	173	13.4547227036395	12	0.891880142335003	0.700699659898291
establishment and/or maintenance of cell polarity	GO:0007163	The specification, formation and maintenance of anisotropic intracellular organization or cell growth patterns.	23	1.78877816291161	3	1.67712244156473	0.263877345481983
regulation of cell shape	GO:0008360	Any process that modulates the shape of a cell.	7	0.544410745233969	0	0	1
regulation of cell size	GO:0008361	Any process that modulates the size of a cell.	122	9.48830155979203	9	0.948536462852185	0.614219727188094
negative regulation of cell size	GO:0045792	Any process that reduces cell size.	28	2.17764298093588	2	0.918424194190211	0.65169040816838
cytoplasm organization and biogenesis	GO:0007028	The assembly and arrangement of the cytoplasm and its components.	434	33.7534662045061	48	1.42207617164936	0.00923342435903387
intercellular junction assembly and/or maintenance	GO:0045216	The assembly and maintenance of junctions between cells.	12	0.933275563258232	1	1.07149489322191	0.621510182350567
intercellular junction assembly	GO:0007043	The formation of a junction between cells.	9	0.699956672443674	0	0	1
organelle organization and biogenesis	GO:0006996	The assembly and arrangement of any organelle within a cell.	383	29.7870450606586	46	1.54429551190208	0.00237391973576879
cytoskeleton organization and biogenesis	GO:0007010	The assembly and arrangement of cytoskeletal structures.	314	24.4207105719237	39	1.59700512747725	0.00270188617886149
actin filament-based process	GO:0030029	Any cellular process that depends upon or alters the actin cytoskeleton (that part of the cytoskeleton comprising actin filaments and their associated proteins).	118	9.17720970537262	10	1.0896558236155	0.436819008101301
actin cytoskeleton organization and biogenesis	GO:0030036	The assembly and arrangement of cytoskeletal structures comprising actin filaments and their associated proteins.	99	7.69952339688042	10	1.29878168875383	0.240430238366619
actin filament organization	GO:0007015	Control of the spatial distribution of actin filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.	12	0.933275563258232	1	1.07149489322191	0.621510182350567
actin filament bundle formation	GO:0051017	The assembly of actin filament bundles; actin filaments may be oriented with the same or opposite polarities and may be packed with different levels of tightness.	4	0.311091854419411	1	3.21448467966574	0.276645145967116
actin polymerization and/or depolymerization	GO:0008154	Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.	29	2.25541594454073	6	2.66026318317165	0.0221497362299472
actin filament polymerization	GO:0030041	Assembly of actin filaments by the addition of actin monomers to a filament.	17	1.3221403812825	5	3.78174668195969	0.0079542766877979
regulation of actin filament polymerization	GO:0030833	Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.	9	0.699956672443674	4	5.71463943051687	0.00334966308173031
regulation of actin polymerization and/or depolymerization	GO:0008064	Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.	14	1.08882149046794	5	4.59212097095105	0.00313268177521419
regulation of actin filament length	GO:0030832	Any process that controls the length of actin filaments in a cell.	17	1.3221403812825	5	3.78174668195969	0.0079542766877979
actin filament-based movement	GO:0030048	Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.	19	1.4776863084922	0	0	1
cytoskeletal anchoring	GO:0007016	Process by which cytoskeletal filaments are directly or indirectly linked to the plasma membrane.	13	1.01104852686308	0	0	1
microtubule-based process	GO:0007017	Any cellular process that depends upon or alters the microtubule cytoskeleton (that part of the cytoskeleton comprising microtubules and their associated proteins).	113	8.78834488734835	22	2.50331550274854	5.45088361380353e-05
microtubule cytoskeleton organization and biogenesis	GO:0000226	The assembly and arrangement of cytoskeletal structures comprising microtubules and their associated proteins.	46	3.57755632582322	6	1.67712244156473	0.144753936090661
M phase specific microtubule process	GO:0000072	A microtubule-based process that occurs only during M phase of the cell cycle.	22	1.71100519930676	4	2.3378070397569	0.0867867307554927
centrosome cycle	GO:0007098	The process of centrosome duplication and separation. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.	7	0.544410745233969	0	0	1
spindle assembly	GO:0007051	The formation and maintenance of the spindle in mitosis or meiosis.	13	1.01104852686308	2	1.97814441825584	0.268274884596286
mitotic spindle assembly	GO:0007052	The formation and maintenance of the mitotic spindle.	13	1.01104852686308	2	1.97814441825584	0.268274884596286
microtubule nucleation	GO:0007020	The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.	9	0.699956672443674	3	4.28597957288765	0.0276600757776216
tubulin folding	GO:0007021	Folding of the microtubule constituent proteins alpha- and beta-tubulin into the native alpha-beta heterodimer.	7	0.544410745233969	2	3.67369677676084	0.0977020540462852
microtubule polymerization	GO:0046785	The addition of tubulin heterodimers to one or both ends of a microtubule.	9	0.699956672443674	3	4.28597957288765	0.0276600757776216
microtubule-based movement	GO:0007018	Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.	31	2.41096187175043	10	4.14772216731063	7.78313966235718e-05
axon cargo transport	GO:0008088	The directed movement of organelles along microtubules in nerve cell axons.	11	0.855502599653379	5	5.84451759939225	0.000881235782941936
endosome organization and biogenesis	GO:0007032	The assembly and arrangement of endosomes.	27	2.09987001733102	3	1.42865985762922	0.351306942612832
endosome transport	GO:0016197	The directed movement of substances into, out of or mediated by an endosome, a membrane-bound organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.	24	1.86655112651646	3	1.60724233983287	0.285614431155593
lysosome organization and biogenesis	GO:0007040	The assembly and arrangement of lysosomes.	16	1.24436741767764	0	0	1
lysosomal transport	GO:0007041	The directed movement of substances into, out of or within a lysosome.	8	0.622183708838821	0	0	1
mitochondrion organization and biogenesis	GO:0007005	The assembly and arrangement of a mitochondrion.	5	0.388864818024263	3	7.71476323119777	0.00417248463830091
peroxisome organization and biogenesis	GO:0007031	The assembly and arrangement of a peroxisome.	16	1.24436741767764	1	0.803621169916435	0.726217553201261
plasma membrane organization and biogenesis	GO:0007009	The assembly and arrangement of the plasma membrane.	7	0.544410745233969	0	0	1
ribosome biogenesis and assembly	GO:0042254	The processes of biogenesis and assembly of the ribosome and its subunits.	44	3.42201039861352	2	0.584451759939225	0.866358572809123
ribosome biogenesis	GO:0007046	The process of the formation of the constituents of ribosomal subunits and their export to the sites of protein synthesis.	40	3.11091854419411	2	0.642896935933148	0.828477914020744
rRNA processing	GO:0006364	Any process involved in the conversion of a primary ribsomal RNA (rRNA) transcript into a mature rRNA molecule.	13	1.01104852686308	1	0.989072209127919	0.650946457163423
membrane organization and biogenesis	GO:0016044	The assembly and arrangement of membranes inside and surrounding the cell.	12	0.933275563258232	4	4.28597957288765	0.0108899304991899
nuclear organization and biogenesis	GO:0006997	The assembly and arrangement of the nucleus.	192	14.9324090121317	9	0.602715877437326	0.966575438808516
chromosome organization and biogenesis (sensu Eukarya)	GO:0007001	The assembly and arrangement of the eukaryotic chromosomes, structures composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.	190	14.776863084922	9	0.609060255094561	0.963621417395772
establishment and/or maintenance of chromatin architecture	GO:0006325		143	11.1215337954939	7	0.629409587626858	0.934043544548774
chromatin assembly/disassembly	GO:0006333		81	6.29961005199307	4	0.634959936724096	0.883610616584396
nucleosome assembly	GO:0006334		43	3.34423743500867	3	0.897065491999741	0.660123618485486
chromatin modification	GO:0016568		74	5.7551993067591	3	0.521267785891741	0.933866707965419
covalent chromatin modification	GO:0016569		9	0.699956672443674	0	0	1
histone modification	GO:0016570		9	0.699956672443674	0	0	1
histone deacetylation	GO:0016575	The modification of histones by removal of acetyl groups.	6	0.466637781629116	0	0	1
non-covalent chromatin modification	GO:0016582		36	2.7998266897747	2	0.714329928814609	0.781169733771809
chromatin remodeling	GO:0006338	Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.	36	2.7998266897747	2	0.714329928814609	0.781169733771809
chromatin silencing	GO:0006342	Repression of transcription by conversion of large regions of DNA into an inaccessible state often called heterochromatin.	12	0.933275563258232	1	1.07149489322191	0.621510182350567
telomere maintenance	GO:0000723	The maintenance of proper telomeric length by processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA.	23	1.78877816291161	1	0.559040813854911	0.844664560448951
telomerase-dependent telomere maintenance	GO:0007004	Maintaining telomeric DNA is a balance between shortening, caused by the failure of normal DNA replication to complete replication of the ends, and lengthening of telomeric DNA sequences, which is dependent upon the activity of the telomerase enzyme.	23	1.78877816291161	1	0.559040813854911	0.844664560448951
cell proliferation	GO:0008283	The multiplication or reproduction of cells, resulting in the rapid expansion of a cell population.	1245	96.8273396880416	78	0.80555760647045	0.982048151202445
cell cycle	GO:0007049	The sequence of events by which a cell duplicates its contents and divides in two; comprises, at a minimum, replication and segregation of DNA; during the course of a cell cycle the cell usually also doubles its mass and duplicates all cytoplasmic organelles.	847	65.8737001733102	65	0.986736737559731	0.563024844383315
DNA replication and chromosome cycle	GO:0000067		210	16.3323223570191	12	0.734739355352169	0.898091263538296
chromosome condensation	GO:0030261	The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.	15	1.16659445407279	0	0	1
mitotic chromosome condensation	GO:0007076	Compaction of chromatin structure prior to mitosis in eukaryotic cells.	5	0.388864818024263	0	0	1
sister chromatid cohesion	GO:0007062	The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome.	10	0.777729636048527	0	0	1
chromosome segregation	GO:0007059	The separation of chromosomes into daughter cells during cell division.	24	1.86655112651646	1	0.535747446610956	0.856745457935699
sister chromatid segregation	GO:0000819	The separation of replicated chromosomes into daughter cells during nuclear division.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
mitotic sister chromatid segregation	GO:0000070	The separation of replicated chromosomes into daughter cells during mitotic nuclear division.	7	0.544410745233969	1	1.83684838838042	0.432631852891438
DNA replication	GO:0006260	The process whereby new strands of DNA are synthesized. The template for replication can either be DNA (DNA-dependent DNA replication, GO:0006261) or RNA (RNA-dependent DNA replication, GO:0006278).	174	13.5324956672444	11	0.812858194858003	0.801966610647276
DNA-dependent DNA replication	GO:0006261	The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.	86	6.68847487001733	6	0.897065491999741	0.667282873141475
DNA replication initiation	GO:0006270	The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.	23	1.78877816291161	2	1.11808162770982	0.543371460995577
DNA strand elongation	GO:0006271	The process by which a DNA strand is synthesized from template DNA by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand.	7	0.544410745233969	0	0	1
DNA topological change	GO:0006265	The process by which a transformation is induced in the tertiary structure of a DNA helix. This may be mediated by helicases, which can unwind the DNA duplex, thereby inducing formation of supercoils, or topoisomerases, which catalyze addition or removal of supercoils.	9	0.699956672443674	1	1.42865985762922	0.517451855212534
maintenance of fidelity during DNA-dependent DNA replication	GO:0045005	The correction of errors made during DNA replication by either intrinsic DNA polymerase proofreading activity or via mismatch repair.	19	1.4776863084922	1	0.676733616771734	0.785256933460783
mismatch repair	GO:0006298	A system for the correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.	19	1.4776863084922	1	0.676733616771734	0.785256933460783
regulation of DNA replication	GO:0006275	Any process that modulates the frequency, rate or extent of DNA replication.	14	1.08882149046794	2	1.83684838838042	0.298036386882161
M phase	GO:0000279	The part of the cell cycle comprising nuclear division and cytokinesis.	198	15.3990467937608	13	0.844208097689992	0.774610062428919
M phase of mitotic cell cycle	GO:0000087	The part of a standard cell cycle during which mitosis and cytokinesis take place.	147	11.4326256499133	10	0.874689708752582	0.714390225579274
mitosis	GO:0007067	The division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.	143	11.1215337954939	10	0.899156553752654	0.681694400055148
mitotic anaphase	GO:0000090	The stage of mitosis during which the two sets of chromosomes separate and move away from each other.	11	0.855502599653379	1	1.16890351987845	0.589591496765378
mitotic prophase	GO:0000088	The initial stage of mitosis in which the chromosomes are condensed but are not yet attached to a mitotic spindle.	5	0.388864818024263	0	0	1
regulation of mitosis	GO:0007088	Any process that modulates the frequency, rate or extent of mitosis.	45	3.49978336221837	3	0.85719591457753	0.690332911524407
mitotic checkpoint	GO:0007093	A signal transduction-based surveillance mechanism that ensures accurate chromosome segregation by preventing entry into, passage through and exit from mitosis. Events that may be monitored include the formation of a correctly assembled spindle, the position of the spindle pole (centrosome) and the orientation of the spindle and cellular morphogenesis.	13	1.01104852686308	1	0.989072209127919	0.650946457163423
nuclear division	GO:0000280	The partition of the nucleus and its genetic information into more than one cell deriving from a parent cell, either via meiosis or mitosis.	183	14.232452339688	10	0.70261960211273	0.910161188597765
meiosis	GO:0007126	A specialized cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiosis occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations.	53	4.12196707105719	3	0.72780785199979	0.790956739416238
meiosis I	GO:0007127	The first division of meiosis in which homologous chromosomes are paired and segregated from each other, producing two daughter cells.	28	2.17764298093588	0	0	1
meiotic prophase I	GO:0007128	Prophase of meiosis I; divided into several stages.	28	2.17764298093588	0	0	1
meiotic recombination	GO:0007131	The formation and repair of double strand breaks through a double Holliday junction intermediate that results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.	26	2.02209705372617	0	0	1
mitotic cell cycle	GO:0000278	The most common eukaryotic cell cycle, in which a cell is duplicated without changing ploidy; comprises four successive phases called G1, S, G2, and M.	240	18.6655112651646	20	1.07149489322191	0.40763710331778
G1 phase of mitotic cell cycle	GO:0000080	One of two 'gap' phases in the standard eukaryotic mitotic cell cycle; the interval between the completion of mitosis and the beginning of DNA synthesis.	24	1.86655112651646	0	0	1
traversing start control point of mitotic cell cycle	GO:0007089	Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle.	12	0.933275563258232	0	0	1
G1/S transition of mitotic cell cycle	GO:0000082	Progression from G1 phase to S phase of the standard mitotic cell cycle.	69	5.36633448873483	9	1.67712244156473	0.0861160571529213
regulation of cyclin dependent protein kinase activity	GO:0000079	Any process that modulates the frequency, rate or extent of CDK activity.	41	3.18869150779896	6	1.88164956858482	0.0957010323933541
G2/M transition of mitotic cell cycle	GO:0000086	Progression from G2 phase to M phase of the standard mitotic cell cycle.	52	4.04419410745234	6	1.48360831369188	0.21548845717156
regulation of mitotic cell cycle	GO:0007346	Any process that modulates the frequency, rate or extent of mitotic cell cycle activity.	9	0.699956672443674	0	0	1
regulation of S phase of mitotic cell cycle	GO:0007090	Any process that modulates the frequency, rate or extent of the activity of S phase of mitotic cell cycle.	8	0.622183708838821	0	0	1
regulation of cell cycle	GO:0000074	Any process that modulates the frequency, rate or extent of the cell cycle.	522	40.5974870017331	44	1.08381092647734	0.311330170053261
cell cycle arrest	GO:0007050	Any process by which progression through the cell cycle is halted during one of the normal phases (G1, S, G2, M).	72	5.59965337954939	4	0.714329928814609	0.820613295534383
cell cycle checkpoint	GO:0000075	A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.	39	3.03314558058925	2	0.659381472751946	0.817599634724074
DNA damage response, signal transduction resulting in cell cycle arrest	GO:0000077	A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.	10	0.777729636048527	0	0	1
negative regulation of cell cycle	GO:0045786	Any process that stops, prevents or reduces the rate of cell cycle activity.	118	9.17720970537262	11	1.19862140597706	0.311048610860748
cytokinesis	GO:0000910	The process of dividing a cell to compartmentalize intracellular constituents; usually after growth, replication, and segregation of cellular components.	114	8.86611785095321	7	0.789522552900357	0.791747636726666
regulation of cell proliferation	GO:0042127	Any process that modulates the frequency, rate or extent of cell proliferation.	355	27.6094020797227	19	0.688171368041116	0.970063962518153
negative regulation of cell proliferation	GO:0008285	Any process that stops, prevents or reduces the rate or extent of cell proliferation.	183	14.232452339688	10	0.70261960211273	0.910161188597765
positive regulation of cell proliferation	GO:0008284	Any process that activates or increases the rate or extent of cell proliferation.	159	12.3659012131716	9	0.72780785199979	0.877568301228863
transport	GO:0006810	The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.	1743	135.558275563258	208	1.5343954408961	8.89661443910912e-10
amine/polyamine transport	GO:0015837	The directed movement of amines or polyamines, organic compounds containing one or more amino groups, into, out of, within or between cells.	44	3.42201039861352	4	1.16890351987845	0.45013867833323
amino acid transport	GO:0006865	The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells.	39	3.03314558058925	4	1.31876294550389	0.360379381500773
acidic amino acid transport	GO:0015800	The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of, within or between cells.	5	0.388864818024263	1	2.57158774373259	0.332902596703209
L-glutamate transport	GO:0015813	The directed movement of L-glutamate, the levorotatory isomer of the anion of 2-aminopentanedioic acid, into, out of, within or between cells.	5	0.388864818024263	1	2.57158774373259	0.332902596703209
L-amino acid transport	GO:0015807	The directed movement of levorotatory isomer amino acids into, out of, within or between cells.	11	0.855502599653379	1	1.16890351987845	0.589591496765378
carbohydrate transport	GO:0008643	The directed movement of carbohydrate into, out of, within or between cells. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y.	27	2.09987001733102	1	0.476219952543072	0.887637355797417
monosaccharide transport	GO:0015749	The directed movement of monosaccharides into, out of, within or between cells. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.	17	1.3221403812825	0	0	1
hexose transport	GO:0008645	The directed movement of hexose into, out of, within or between cells. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.	17	1.3221403812825	0	0	1
glucose transport	GO:0015758	The directed movement of the hexose monosaccharide glucose into, out of, within or between cells.	17	1.3221403812825	0	0	1
fluid transport	GO:0042044	The directed movement of substances that are in liquid form in normal living conditions into, out of, within or between cells.	8	0.622183708838821	0	0	1
water transport	GO:0006833	The directed movement of water (H2O) into, out of, within or between cells.	8	0.622183708838821	0	0	1
gas transport	GO:0015669	The directed movement of substances that are gaseous in normal living conditions into, out of, within or between cells.	11	0.855502599653379	4	4.6756140795138	0.00773128171817817
oxygen transport	GO:0015671	The directed movement of oxygen (O2) into, out of, within or between cells.	11	0.855502599653379	4	4.6756140795138	0.00773128171817817
hydrogen transport	GO:0006818	The directed movement of hydrogen (H2 or H+), into, out of, within or between cells.	75	5.83297227036395	24	4.11454038997215	1.19905060660694e-09
proton transport	GO:0015992	The directed movement of protons (hydrogen ions) into, out of, within or between cells.	74	5.7551993067591	24	4.17014228713393	8.80609666413807e-10
energy coupled proton transport, against electrochemical gradient	GO:0015988		12	0.933275563258232	1	1.07149489322191	0.621510182350567
ATP hydrolysis coupled proton transport	GO:0015991		10	0.777729636048527	1	1.2857938718663	0.554981054514678
energy coupled proton transport, down electrochemical gradient	GO:0015985		38	2.9553726169844	17	5.75223574255974	8.11485042300257e-10
ATP synthesis coupled proton transport	GO:0015986	The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.	38	2.9553726169844	17	5.75223574255974	8.11485042300257e-10
intracellular transport	GO:0046907	The directed movement of substances within a cell.	562	43.7084055459272	81	1.8531904558927	7.37677751977995e-08
cytoskeleton-dependent intracellular transport	GO:0030705	The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.	31	2.41096187175043	10	4.14772216731063	7.78313966235718e-05
Golgi vesicle transport	GO:0048193	The directed movement of substances to or from the Golgi apparatus, mediated by vesicles.	71	5.52188041594454	11	1.9920750127506	0.020848311017936
ER to Golgi transport	GO:0006888	The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.	24	1.86655112651646	2	1.07149489322191	0.566803918253758
intra-Golgi transport	GO:0006891	The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).	22	1.71100519930676	0	0	1
post-Golgi transport	GO:0006892	The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane.	21	1.63323223570191	9	5.51054516514127	1.28594733335443e-05
retrograde transport, Golgi to ER	GO:0006890	The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by COP I vesicles.	5	0.388864818024263	0	0	1
intracellular protein transport	GO:0006886	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.	422	32.8201906412478	57	1.73673579849239	3.76604544422527e-05
protein targeting	GO:0006605	The process of targeting specific proteins to particular membrane-bound subcellular organelles. Usually requires an organelle specific protein sequence motif.	143	11.1215337954939	16	1.43865048600425	0.0904932381301955
protein-ER targeting	GO:0045047	The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.	12	0.933275563258232	3	3.21448467966574	0.0608300154045459
cotranslational membrane targeting	GO:0006613	The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner.	10	0.777729636048527	3	3.85738161559889	0.0372685271436536
protein-membrane targeting	GO:0006612	The process of directing proteins towards a membrane using signals contained within the protein.	16	1.24436741767764	4	3.21448467966574	0.0311965194000763
protein-mitochondrial targeting	GO:0006626	The process of directing proteins towards and into the mitochondrion, mediated by mitochondrial proteins that recognize signals contained within the imported protein.	22	1.71100519930676	2	1.16890351987845	0.51906762486396
protein-nucleus import	GO:0006606	The directed movement of a protein from the cytoplasm to the nucleus.	74	5.7551993067591	7	1.21629150041406	0.352735886696841
NLS-bearing substrate-nucleus import	GO:0006607	The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane.	25	1.94432409012132	4	2.05727019498607	0.125242206350472
protein-nucleus import, docking	GO:0000059		17	1.3221403812825	2	1.51269867278388	0.385531596872848
protein-nucleus import, translocation	GO:0000060	The vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane.	21	1.63323223570191	2	1.22456559225361	0.493912087895391
regulation of protein-nucleus import	GO:0042306	Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.	9	0.699956672443674	0	0	1
regulation of transcription factor-nucleus import	GO:0042990	Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.	9	0.699956672443674	0	0	1
negative regulation of transcription factor-nucleus import	GO:0042992	Any process that stops, prevents or reduces the rate of the movement of a transcription factor from the cytoplasm to the nucleus.	7	0.544410745233969	0	0	1
cytoplasmic sequestering of transcription factor	GO:0042994	The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.	7	0.544410745233969	0	0	1
regulation of NF-kappaB-nucleus import	GO:0042345	Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.	6	0.466637781629116	0	0	1
transcription factor-nucleus import	GO:0042991	The directed movement of a transcription factor from the cytoplasm to the nucleus.	9	0.699956672443674	0	0	1
NF-kappaB-nucleus import	GO:0042348	The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.	6	0.466637781629116	0	0	1
mitochondrial transport	GO:0006839	Transport of substances into, out of or within a mitochondrion.	21	1.63323223570191	6	3.67369677676084	0.00431708949720852
nucleocytoplasmic transport	GO:0006913	The directed movement of molecules between the nucleus and the cytoplasm.	130	10.1104852686308	10	0.98907220912792	0.561409594187481
regulation of nucleocytoplasmic transport	GO:0046822	Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.	9	0.699956672443674	0	0	1
RNA-nucleus export	GO:0006405	The export of RNA from the nucleus to the cytoplasm.	51	3.96642114384749	2	0.504232890927959	0.914674019976109
mRNA-nucleus export	GO:0006406	The export of mRNA from the nucleus to the cytoplasm.	41	3.18869150779896	1	0.313608261430804	0.963829721624951
ion transport	GO:0006811	The directed movement of charged atoms or small charged molecules into, out of, within or between cells.	651	50.6301993067591	73	1.44182722958893	0.00118175111492322
anion transport	GO:0006820	The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells.	187	14.5435441941075	14	0.962626428135194	0.598243323774401
inorganic anion transport	GO:0015698	The directed movement of inorganic anions into, out of, within or between cells. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.	144	11.1993067590988	8	0.714329928814609	0.879248480286358
chloride transport	GO:0006821	The directed movement of chloride into, out of, within or between cells.	50	3.88864818024263	5	1.2857938718663	0.348412837921869
phosphate transport	GO:0006817	The directed movement of phosphate into, out of, within or between cells.	84	6.53292894280762	3	0.459212097095106	0.963419081888637
sulfate transport	GO:0008272	The directed movement of sulfate into, out of, within or between cells.	10	0.777729636048527	0	0	1
organic anion transport	GO:0015711	The directed movement of organic anions into, out of, within or between cells. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.	34	2.64428076256499	2	0.756349336391938	0.753457253912228
dicarboxylic acid transport	GO:0006835	The directed movement of dicarboxylic acids into, out of, within or between cells.	10	0.777729636048527	2	2.57158774373259	0.17968906149323
monocarboxylic acid transport	GO:0015718	The directed movement of monocarboxylic acids into, out of, within or between cells.	21	1.63323223570191	0	0	1
cation transport	GO:0006812	The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells.	423	32.8979636048527	55	1.67183600360866	0.000139736854100564
di-, tri-valent inorganic cation transport	GO:0015674	The directed movement of inorganic cations with a valency of two or three into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.	147	11.4326256499133	12	1.0496276505031	0.474288577268416
calcium ion transport	GO:0006816	The directed movement of calcium (Ca) ions into, out of, within or between cells.	94	7.31065857885615	11	1.50465240324779	0.113207723884393
transition metal ion transport	GO:0000041	The directed movement of transition metal ions into, out of, within or between cells. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.	53	4.12196707105719	1	0.242602617333263	0.986309917933498
copper ion transport	GO:0006825	The directed movement of copper (Cu) ions into, out of, within or between cells.	10	0.777729636048527	0	0	1
iron ion transport	GO:0006826	The directed movement of iron (Fe) ions into, out of, within or between cells.	36	2.7998266897747	1	0.357164964407304	0.94577961449663
zinc ion transport	GO:0006829	The directed movement of zinc (Zn) ions into, out of, within or between cells.	4	0.311091854419411	0	0	1
metal ion transport	GO:0030001	The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells.	339	26.3650346620451	33	1.25165775137427	0.109100109200122
potassium ion transport	GO:0006813	The directed movement of potassium ions (K+) into, out of, within or between cells.	147	11.4326256499133	16	1.39950353400413	0.108550105894996
sodium ion transport	GO:0006814	The directed movement of sodium ions (Na+) into, out of, within or between cells.	79	6.14406412478336	8	1.30206974366207	0.271024167544346
monovalent inorganic cation transport	GO:0015672	The directed movement of inorganic cations with a valency of one into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.	264	20.5320623916811	44	2.14298978644383	1.45528966774437e-06
lipid transport	GO:0006869	The directed movement of lipids into, out of, within or between cells. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.	70	5.44410745233969	4	0.734739355352169	0.803288963216945