Welcome to the L2L Microarray Analysis ToolA simple tool for discovering the hidden biological significance in microarray expression data. |
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| Results summary | View all lists in GO:CellComp | View all genes in alzheimers_dn |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | 584 | 45.42 | 145 | 3.19 | 3.87e-36 |
| cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | 3309 | 257.35 | 411 | 1.60 | 1.47e-20 |
| inner membrane | The inner membrane of organelles such as mitochondria and chloroplasts; highly selective to most ions and metabolites (contrast outer membrane GO:0019867). | 114 | 8.87 | 39 | 4.40 | 7.60e-16 |
| mitochondrial inner membrane | The inner membrane of the mitochondria. It is highly folded to form cristae. | 88 | 6.84 | 30 | 4.38 | 1.71e-12 |
| mitochondrial membrane | The lipid bilayer surrounding the mitochondrion and separating its contents from the cell cytoplasm. | 131 | 10.19 | 36 | 3.53 | 1.51e-11 |
| proton-transporting two-sector ATPase complex | A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (F0, V0, A0) and a cytoplasmic compartment sector (F1, V1, A1). The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits, as well as the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archebacterial) enzymes have a similar structure but, under physiological conditions, they pump hydrogen ion rather than synthesize ATP. | 38 | 2.96 | 17 | 5.75 | 8.11e-10 |
| synaptic vesicle | Secretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. | 27 | 2.10 | 11 | 5.24 | 2.53e-06 |
| mitochondrial electron transport chain | The protein complexes that form the mitochondrial electron transport system (the respiratory chain). Complexes I, III and IV can transport protons if embedded in an oriented membrane, such as an intact mitochondrial inner membrane. | 15 | 1.17 | 8 | 6.86 | 5.22e-06 |
| intracellular | The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. | 5791 | 450.38 | 543 | 1.21 | 5.50e-06 |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of the cell. | 125 | 9.72 | 25 | 2.57 | 1.08e-05 |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). | 443 | 34.45 | 61 | 1.77 | 1.15e-05 |
| proteasome complex (sensu Eukarya) | A large multisubunit complex which catalyzes protein degradation, as seen in eukaryotes. This complex consists of the barrel shaped proteasome core complex and the regulatory particle that caps the proteasome core complex. | 49 | 3.81 | 14 | 3.67 | 1.46e-05 |
| coated vesicle | Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. | 97 | 7.54 | 21 | 2.78 | 1.51e-05 |
| proteasome core complex (sensu Eukarya) | A multisubunit barrel shaped endoprotease complex as seen in eukaryotes, which is the core of the proteasome complex. This complex is involved in the proteolysis of substrates in an ATP dependent manner and consists of four ring-like structures, two outer and two inner, each containing seven subunits. | 27 | 2.10 | 10 | 4.76 | 1.98e-05 |
| cytosol | That part of the cytoplasm that does not contain membranous or particulate subcellular components. | 364 | 28.31 | 51 | 1.80 | 3.58e-05 |
| neurofilament | A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter. | 7 | 0.54 | 5 | 9.18 | 5.23e-05 |
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. | 84 | 6.53 | 18 | 2.76 | 6.90e-05 |
| hydrogen-translocating F-type ATPase complex | 11 | 0.86 | 6 | 7.01 | 7.25e-05 | |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. | 64 | 4.98 | 15 | 3.01 | 9.30e-05 |
| heterotrimeric G-protein complex | Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors (GO:0004930) to an effector protein. | 40 | 3.11 | 11 | 3.54 | 1.74e-04 |
| nuclear envelope-endoplasmic reticulum network | The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum. | 69 | 5.37 | 15 | 2.80 | 2.28e-04 |
| extrinsic to plasma membrane | Loosely bound, by ionic or covalent forces, to one or other surface of the plasma membrane, but not integrated into the hydrophobic region. | 44 | 3.42 | 11 | 3.21 | 4.31e-04 |
| integral to endoplasmic reticulum membrane | Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer. | 21 | 1.63 | 7 | 4.29 | 7.52e-04 |
| microtubule associated complex | Any multimeric complex connected to a microtubule. | 69 | 5.37 | 14 | 2.61 | 7.61e-04 |
| signal recognition particle | A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. | 11 | 0.86 | 5 | 5.84 | 8.81e-04 |
| cell | The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. | 8352 | 649.56 | 722 | 1.11 | 1.88e-03 |
| small nucleolar ribonucleoprotein complex | Any of various particulate complexes of proteins with molecules of small nucleolar RNA (any of a class of small RNAs that participate in the processing of ribosomal RNA; they contain a long stretch of sequence complementarity to conserved sequences in mature mRNA), found in the eukaryotic nucleolus. They are possibly the same as processosomes. | 20 | 1.56 | 6 | 3.86 | 3.30e-03 |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes concerned with fatty-acid oxidation and enzymes of the tricarboxylic acid cycle. | 73 | 5.68 | 13 | 2.29 | 3.91e-03 |
| extrinsic to membrane | Loosely bound, by ionic or covalent forces, to one or other surface of a membrane, but not integrated into the hydrophobic region. | 57 | 4.43 | 11 | 2.48 | 4.07e-03 |
| synapse | The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. | 91 | 7.08 | 15 | 2.12 | 4.37e-03 |
| protein serine/threonine phosphatase complex | A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. | 43 | 3.34 | 9 | 2.69 | 5.16e-03 |
| microtubule cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules. | 148 | 11.51 | 21 | 1.82 | 5.44e-03 |
| unlocalized | Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products (see: cellular_component unknown, GO:0008372). | 87 | 6.77 | 14 | 2.07 | 7.15e-03 |
| voltage-gated sodium channel complex | A sodium channel in a cell membrane whose opening is governed by the membrane potential. | 6 | 0.47 | 3 | 6.43 | 7.86e-03 |
| cell fraction | A generic term for parts of cells prepared by disruptive biochemical techniques. | 874 | 67.97 | 88 | 1.29 | 8.50e-03 |
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