Welcome to the L2L Microarray Analysis ToolA simple tool for discovering the hidden biological significance in microarray expression data. |
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| Results summary | View all lists in GO:MoleFunc | View all genes in alzheimers_dn |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| hydrogen ion transporter activity | Enables the directed movement of hydrogen ions into, out of, within or between cells. | 131 | 10.19 | 60 | 5.89 | 1.19e-31 |
| monovalent inorganic cation transporter activity | Enables the directed movement of inorganic cations with a valency of one into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. | 146 | 11.35 | 61 | 5.37 | 2.09e-29 |
| cation transporter activity | Enables the directed movement of atoms or small molecules with a positive charge into, out of, within or between cells. | 236 | 18.35 | 68 | 3.70 | 1.18e-21 |
| primary active transporter activity | Catalysis of transport of a solute against a concentration gradient using a primary energy source. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources. | 249 | 19.37 | 70 | 3.61 | 1.42e-21 |
| ion transporter activity | Enables the directed movement of charged atoms or small charged molecules into, out of, within or between cells. | 286 | 22.24 | 73 | 3.28 | 8.85e-20 |
| transporter activity | Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. | 1504 | 116.97 | 214 | 1.83 | 1.83e-17 |
| carrier activity | Catalysis of the transfer of a specific substance or related group of substances from one side of the membrane to the other. | 436 | 33.91 | 85 | 2.51 | 4.53e-15 |
| oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. | 41 | 3.19 | 22 | 6.90 | 2.24e-14 |
| NADH dehydrogenase (ubiquinone) activity | Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. | 39 | 3.03 | 21 | 6.92 | 7.95e-14 |
| NADH dehydrogenase activity | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. | 38 | 2.96 | 20 | 6.77 | 5.52e-13 |
| catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. | 3597 | 279.75 | 401 | 1.43 | 6.02e-13 |
| oxidoreductase activity, acting on NADH or NADPH | Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. | 64 | 4.98 | 25 | 5.02 | 3.64e-12 |
| sodium ion transporter activity | Enables the directed movement of sodium ions (Na+) into, out of, within or between cells. | 47 | 3.66 | 21 | 5.75 | 8.65e-12 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. | 464 | 36.09 | 77 | 2.13 | 2.99e-10 |
| electron transporter activity | Enables the directed movement of electrons into, out of, within or between cells. | 248 | 19.29 | 50 | 2.59 | 4.84e-10 |
| hydrogen-transporting ATPase activity, rotational mechanism | Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. | 38 | 2.96 | 17 | 5.75 | 8.11e-10 |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. | 532 | 41.38 | 83 | 2.01 | 1.34e-09 |
| hydrogen-transporting ATP synthase activity, rotational mechanism | Catalysis of the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. | 35 | 2.72 | 16 | 5.88 | 1.72e-09 |
| oxidoreductase activity, acting on heme group of donors, oxygen as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen. | 25 | 1.94 | 13 | 6.69 | 8.07e-09 |
| cbb3-type cytochrome c oxidase | OBSOLETE. Catalysis of the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. | 12 | 0.93 | 9 | 9.64 | 1.84e-08 |
| metal ion transporter activity | Enables the directed movement of metal ions into, out of, within or between cells. | 93 | 7.23 | 25 | 3.46 | 2.91e-08 |
| ATPase activity, coupled to transmembrane movement of ions | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. | 89 | 6.92 | 24 | 3.47 | 5.11e-08 |
| chaperone activity | Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function. | 179 | 13.92 | 36 | 2.59 | 1.26e-07 |
| GTP binding | Interacting selectively with GTP, guanosine triphosphate. | 236 | 18.35 | 42 | 2.29 | 4.22e-07 |
| hydrogen-transporting two-sector ATPase activity | OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). | 25 | 1.94 | 11 | 5.66 | 1.00e-06 |
| guanyl nucleotide binding | Interacting selectively with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. | 245 | 19.05 | 42 | 2.20 | 1.17e-06 |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. | 1507 | 117.20 | 169 | 1.44 | 1.53e-06 |
| GTPase activity | Catalysis of the hydrolysis of GTP to GDP and orthophosphate. | 146 | 11.35 | 29 | 2.55 | 2.59e-06 |
| purine nucleotide binding | Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate. | 1330 | 103.44 | 149 | 1.44 | 6.31e-06 |
| nucleotide binding | Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety. | 1340 | 104.22 | 149 | 1.43 | 9.31e-06 |
| SNARE binding | Interacting selectively with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. | 12 | 0.93 | 7 | 7.50 | 9.59e-06 |
| ATPase activity, coupled to transmembrane movement of substances | Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance across a membrane. | 157 | 12.21 | 29 | 2.38 | 1.14e-05 |
| ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. | 293 | 22.79 | 44 | 1.93 | 2.22e-05 |
| protein transporter activity | Enables the directed movement of proteins into, out of, within or between cells. | 306 | 23.80 | 45 | 1.89 | 3.06e-05 |
| P-P-bond-hydrolysis-driven transporter activity | Catalysis of the transport of a solute, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. | 175 | 13.61 | 30 | 2.20 | 3.63e-05 |
| heat shock protein activity | Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones. | 47 | 3.66 | 13 | 3.56 | 4.27e-05 |
| ATPase activity, coupled | Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane. | 285 | 22.17 | 42 | 1.89 | 5.22e-05 |
| malate dehydrogenase activity | Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate using NAD+ or NADPH. | 9 | 0.70 | 5 | 7.14 | 2.74e-04 |
| ARF small monomeric GTPase activity | OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. | 10 | 0.78 | 5 | 6.43 | 5.14e-04 |
| protein domain specific binding | Interacting selectively with a specific domain of a protein. | 45 | 3.50 | 11 | 3.14 | 5.31e-04 |
| ligase activity | Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. | 196 | 15.24 | 29 | 1.90 | 6.43e-04 |
| microtubule motor activity | Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). | 21 | 1.63 | 7 | 4.29 | 7.52e-04 |
| adenyl nucleotide binding | Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. | 1120 | 87.11 | 117 | 1.34 | 8.27e-04 |
| proteasome endopeptidase activity | OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity. | 22 | 1.71 | 7 | 4.09 | 1.03e-03 |
| ATP binding | Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | 1105 | 85.94 | 114 | 1.33 | 1.46e-03 |
| thiolester hydrolase activity | 44 | 3.42 | 10 | 2.92 | 1.71e-03 | |
| ubiquitin conjugating enzyme activity | Functions to link ubiquitin to lysine residues on a target protein. This function may be performed alone or in conjunction with E3, ubiquitin-protein ligase. | 59 | 4.59 | 12 | 2.62 | 1.73e-03 |
| ubiquitin thiolesterase activity | Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. | 37 | 2.88 | 9 | 3.13 | 1.74e-03 |
| ubiquinol-cytochrome-c reductase activity | Catalysis of the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c. | 8 | 0.62 | 4 | 6.43 | 1.98e-03 |
| small protein conjugating enzyme activity | 60 | 4.67 | 12 | 2.57 | 2.01e-03 | |
| ubiquitin-specific protease activity | Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups. | 38 | 2.96 | 9 | 3.05 | 2.12e-03 |
| molecular_function | Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. | 10093 | 784.96 | 862 | 1.10 | 2.48e-03 |
| lipid binding | Interacting selectively with a lipid. | 176 | 13.69 | 25 | 1.83 | 2.57e-03 |
| ligase activity, forming carbon-carbon bonds | Catalysis of the ligation of two substances via a carbon-carbon bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. | 9 | 0.70 | 4 | 5.71 | 3.35e-03 |
| electron carrier activity | Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. | 15 | 1.17 | 5 | 4.29 | 4.40e-03 |
| GABA receptor activity | Combining with the neurotransmitter GABA (gamma aminobutyric acid) to initiate a change in cell activity. | 28 | 2.18 | 7 | 3.21 | 4.73e-03 |
| oxygen transporter activity | Enables the directed movement of oxygen into, out of, within or between cells. | 11 | 0.86 | 4 | 4.68 | 7.73e-03 |
| motor activity | Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. | 116 | 9.02 | 17 | 1.88 | 8.46e-03 |
| ubiquitin-protein ligase activity | Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Catalyzes the mediation of substrate recognition in ubiquitin-mediated protein degradation; binds directly to the substrate and its cognate E2 (ubiquitin conjugating enzyme). | 64 | 4.98 | 11 | 2.21 | 9.94e-03 |
| ligase activity, forming carbon-nitrogen bonds | Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. | 118 | 9.18 | 17 | 1.85 | 9.98e-03 |
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