Welcome to the L2L Microarray Analysis ToolA simple tool for discovering the hidden biological significance in microarray expression data. |
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| Results summary | View all lists in L2L MDB | View all genes in alzheimers_dn |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alzheimers_disease_dn | Downregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus | 2123 | 165.11 | 1333 | 8.07 | 0.00e+00 |
| alzheimers_incipient_dn | Downregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus | 306 | 23.80 | 197 | 8.28 | 7.94e-138 |
| ageing_brain_dn | Age-downregulated in the human frontal cortex | 229 | 17.81 | 74 | 4.15 | 7.62e-27 |
| ventricle_up | Upregulated in the ventricles of healthy hearts, compared to atria | 369 | 28.70 | 68 | 2.37 | 3.10e-11 |
| aged_mouse_cortex_dn | Down-regulated in the cerebral cortex of aged (22 months) BALB/c mice, compared to young (2 months) controls | 86 | 6.69 | 27 | 4.04 | 1.85e-10 |
| microrna_human | Predicted human MicroRNA targets | 3269 | 254.24 | 355 | 1.40 | 2.53e-10 |
| uvb_scc_up | Upregulated by UV-B light in squamous cell carcinoma cells | 216 | 16.80 | 45 | 2.68 | 1.16e-09 |
| microrna_mammal | Predicted MicroRNA targets conserved across human, mouse and rat | 1879 | 146.14 | 215 | 1.47 | 1.45e-08 |
| calres_rhesus_dn | Downregulated in the vastus lateralis muscle of middle-aged rhesus monkeys subjected to caloric restriction since young adulthood vs. age-matched controls | 99 | 7.70 | 26 | 3.38 | 2.63e-08 |
| aged_mouse_hypoth_up | Up-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls | 80 | 6.22 | 22 | 3.54 | 1.24e-07 |
| idx_tsa_up_cluster6 | Strongly up-regulated at 96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 218 | 16.95 | 39 | 2.30 | 9.29e-07 |
| hdaci_colon_tsa30min_dn | Downregulated by TSA at 30 min in SW260 colon carcinoma cells | 38 | 2.96 | 13 | 4.40 | 3.20e-06 |
| rcc_nl_up | Upregulated in VHL-rescued renal carcinoma vs. normal renal cells (Fig. 2) | 362 | 28.15 | 52 | 1.85 | 1.53e-05 |
| platelet_expressed | Fifty genes most strongly expressed in human platlets from three healthy donors | 77 | 5.99 | 18 | 3.01 | 2.01e-05 |
| idx_tsa_up_cluster5 | Up-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 5) | 114 | 8.87 | 23 | 2.59 | 2.06e-05 |
| heartfailure_atria_dn | Downregulated in the atria of failing hearts (DCM and ICM) compared to healthy controls | 212 | 16.49 | 34 | 2.06 | 4.74e-05 |
| uvb_nhek2_up | Upregulated by UV-B light in normal human epidermal keratinocytes | 120 | 9.33 | 23 | 2.46 | 4.83e-05 |
| aged_mouse_hypoth_dn | Down-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls | 58 | 4.51 | 14 | 3.10 | 1.12e-04 |
| diab_neph_dn | Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls | 684 | 53.20 | 81 | 1.52 | 1.24e-04 |
| aged_rhesus_dn | Downregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys | 187 | 14.54 | 30 | 2.06 | 1.26e-04 |
| 3ab_gamma_up | Upregulated synergystically by gamma-irradiation and 3-aminobenzamine (PARP inhibitor) | 9 | 0.70 | 5 | 7.14 | 2.74e-04 |
| oldwerner_dn | Commonly downregulated in fibroblasts from Werner Syndrome and old individuals, compared to young | 270 | 21.00 | 37 | 1.76 | 5.89e-04 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 358 | 27.84 | 46 | 1.65 | 5.96e-04 |
| cantharidin_dn | Downregulated in HL-60 promyeloid leukemic cells after treatment with the cytotoxic drug cantharidin | 88 | 6.84 | 16 | 2.34 | 1.16e-03 |
| egf_hdmec_up | Up-regulated in human dermal (foreskin) microvascular endothelial cells that were stimulated to proliferate with prolonged EGF treatment, versus non-stimulated quiescent controls. | 105 | 8.17 | 18 | 2.20 | 1.21e-03 |
| hdaci_colon_but12hrs_dn | Downregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 258 | 20.07 | 34 | 1.69 | 1.86e-03 |
| cancer_neoplastic_meta_up | Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database | 109 | 8.48 | 18 | 2.12 | 1.87e-03 |
| nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 45 | 3.50 | 10 | 2.86 | 2.05e-03 |
| hdaci_colon_alltsa_dn | Downregulated by TSA at any timepoint in SW260 colon carcinoma cells | 129 | 10.03 | 20 | 1.99 | 2.36e-03 |
| ros_mouse_aorta_up | Up-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone | 19 | 1.48 | 6 | 4.06 | 2.47e-03 |
| igfr_ir_dn | Down-regulated in common following stimulation of chimeric TrkC/IR or TrkC/IGFR in NIH3T3 cells | 32 | 2.49 | 8 | 3.21 | 2.58e-03 |
| elongina_ko_dn | Downregulated in MES cells from elongin-A knockout mice | 229 | 17.81 | 30 | 1.68 | 3.61e-03 |
| heatshock_old_up | Upregulated after heat shock in lymphocytes from young individuals, compared to old | 41 | 3.19 | 9 | 2.82 | 3.69e-03 |
| heartfailure_ventricles_dn | Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls | 116 | 9.02 | 18 | 2.00 | 3.75e-03 |
| ribosome_mito | Mitochondrial ribosomal proteins | 57 | 4.43 | 11 | 2.48 | 4.07e-03 |
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