Welcome to the L2L Microarray Analysis ToolA simple tool for discovering the hidden biological significance in microarray expression data. |
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| Results summary | View all lists in L2L MDB | View all genes in alzheimers_up |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alzheimers_disease_up | Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus | 3172 | 339.64 | 1752 | 5.16 | 0.00e+00 |
| alzheimers_incipient_up | Upregulated in correlation with incipient Alzheimer's Disease, in the CA1 region of the hippocampus | 781 | 83.62 | 438 | 5.24 | 1.66e-211 |
| ageing_brain_up | Age-upregulated in the human frontal cortex | 396 | 42.40 | 96 | 2.26 | 1.64e-14 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 154 | 16.49 | 44 | 2.67 | 8.10e-10 |
| tpa_skin_up | Upregulated in murine dorsal skin cells 6 hours after treatment with the phorbol ester carcinogen TPA | 28 | 3.00 | 12 | 4.00 | 1.32e-05 |
| heartfailure_atria_up | Upregulated in atria of failing hearts (DCM and ICM) compared to healthy controls | 53 | 5.67 | 17 | 3.00 | 2.29e-05 |
| uvb_nhek2_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 145 | 15.53 | 31 | 2.00 | 1.36e-04 |
| tgfbeta_cluster1_up | Upregulated by TGF-beta treatment of fibroblasts (Fig. 1 Cluster 1) | 35 | 3.75 | 12 | 3.20 | 1.76e-04 |
| oxstress_rpetwo_dn | Downregulated by two of H2O2, HNE and t-BH in retinal pigment epithelium cells (Tables 3-5) | 312 | 33.41 | 54 | 1.62 | 2.91e-04 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 106 | 11.35 | 24 | 2.11 | 3.01e-04 |
| tgfbeta_all_up | Upregulated by TGF-beta treatment of fibroblasts, at any timepoint | 188 | 20.13 | 36 | 1.79 | 4.15e-04 |
| idx_tsa_dn_cluster1 | Down-regulated at 48-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 57 | 6.10 | 15 | 2.46 | 7.60e-04 |
| atria_up | Upregulated in the atria of healthy hearts, compared to venticles | 368 | 39.40 | 59 | 1.50 | 1.15e-03 |
| dsrna_up | Upregulated by dsRNA (polyI:C) in IFN-null GRE cells | 68 | 7.28 | 16 | 2.20 | 1.88e-03 |
| myc_bp | c-Myc binding proteins | 23 | 2.46 | 8 | 3.25 | 1.92e-03 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 370 | 39.62 | 58 | 1.46 | 2.12e-03 |
| calres_mouse_neocortex_up | Upregulated in the neocortex of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls | 88 | 9.42 | 19 | 2.02 | 2.19e-03 |
| hypoxia_compilation_up | Compilation of upregulated genes from all hypoxia-related lists | 665 | 71.20 | 94 | 1.32 | 3.49e-03 |
| hypoxia_fibro_young_up | Upregulated by hypoxia in normal fibroblasts from young, but not old, donors | 16 | 1.71 | 6 | 3.50 | 4.65e-03 |
| dnmt1_ko_up | Upregulated following conditional knock-out of DNMT1 in MEFs | 122 | 13.06 | 23 | 1.76 | 5.07e-03 |
| ifn_alpha_up | Upregulated by treatment with IFN-alpha | 123 | 13.17 | 23 | 1.75 | 5.62e-03 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 44 | 4.71 | 11 | 2.33 | 5.66e-03 |
| ifn_beta_up | Upregulated by treatment with IFN-beta | 166 | 17.77 | 29 | 1.63 | 5.69e-03 |
| hdaci_colon_but24hrs_dn | Downregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 421 | 45.08 | 62 | 1.38 | 6.43e-03 |
| uvb_nhek1_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 519 | 55.57 | 74 | 1.33 | 7.01e-03 |
| hdaci_colon_allbut_dn | Downregulated by butyrate at any timepoint in SW260 colon carcinoma cells | 496 | 53.11 | 71 | 1.34 | 7.41e-03 |
| cmv_dn | Downregulated by infection of fibroblasts with CMV | 170 | 18.20 | 29 | 1.59 | 7.94e-03 |
| tgfbeta_cluster5_up | Upregulated by TGF-beta treatment of fibroblasts (Fig. 1 Cluster 5) | 40 | 4.28 | 10 | 2.33 | 8.16e-03 |
| calres_rhesus_up | Upregulated in the vastus lateralis muscle of middle-aged rhesus monkeys subjected to caloric restriction since young adulthood vs. age-matched controls | 106 | 11.35 | 20 | 1.76 | 8.47e-03 |
| microrna_human | Predicted human MicroRNA targets | 3269 | 350.02 | 393 | 1.12 | 8.91e-03 |
| aged_rhesus_dn | Downregulated in the vastus lateralis muscle of aged vs. young adult rhesus monkeys | 187 | 20.02 | 31 | 1.55 | 9.39e-03 |
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