Welcome to the L2L Microarray Analysis ToolA simple tool for discovering the hidden biological significance in microarray expression data. |
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| Results summary | View all lists in GO:BiolProc | View all genes in diab_neph_dn |
| List Name | Notes | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| caspase activation | Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis. | 22 | 0.95 | 9 | 9.47 | 1.56e-07 |
| tyrosine phosphorylation of STAT protein | The process of introducing a phosphoric group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. | 18 | 0.78 | 8 | 10.29 | 3.58e-07 |
| peptidyl-tyrosine phosphorylation | The posttranslational phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. | 25 | 1.08 | 9 | 8.34 | 5.68e-07 |
| peptidyl-tyrosine modification | The modification of peptidyl-tyrosine. | 27 | 1.17 | 9 | 7.72 | 1.20e-06 |
| peptidyl-amino acid modification | 32 | 1.38 | 9 | 6.51 | 5.92e-06 | |
| protein-nucleus import, translocation | The vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. | 20 | 0.86 | 7 | 8.10 | 1.32e-05 |
| apoptotic program | The genetically programmed processes that occur during apoptosis. | 53 | 2.29 | 11 | 4.81 | 1.38e-05 |
| I-kappaB kinase/NF-kappaB cascade | A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase. | 99 | 4.28 | 14 | 3.27 | 9.34e-05 |
| protein targeting | The process of targeting specific proteins to particular membrane-bound subcellular organelles. Usually requires an organelle specific protein sequence motif. | 115 | 4.97 | 15 | 3.02 | 1.36e-04 |
| cellular morphogenesis | Any process that modulates the mass, volume, or shape of a cell. | 157 | 6.78 | 18 | 2.65 | 1.66e-04 |
| JAK-STAT cascade | The processes by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. | 48 | 2.07 | 9 | 4.34 | 1.89e-04 |
| protein-nucleus import | The directed movement of a protein from the cytoplasm to the nucleus. | 64 | 2.76 | 10 | 3.62 | 4.02e-04 |
| negative regulation of cell proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. | 155 | 6.69 | 17 | 2.54 | 4.19e-04 |
| cell adhesion | The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules. | 561 | 24.23 | 42 | 1.73 | 4.88e-04 |
| growth | The increase in size or mass of an entire organism (as used in GO), as opposed to cell growth (GO:0016049). | 133 | 5.74 | 15 | 2.61 | 6.65e-04 |
| nucleotide-sugar metabolism | The chemical reactions and physical changes involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. | 12 | 0.52 | 4 | 7.72 | 1.30e-03 |
| protein kinase cascade | A series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. | 254 | 10.97 | 22 | 2.01 | 1.70e-03 |
| regulation of cell growth | Any process that modulates the frequency, rate or extent of cell growth. | 80 | 3.46 | 10 | 2.89 | 2.34e-03 |
| N-acetylglucosamine metabolism | The chemical reactions and physical changes involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein. | 7 | 0.30 | 3 | 9.92 | 2.47e-03 |
| nucleocytoplasmic transport | The directed movement of molecules between the nucleus and the cytoplasm. | 96 | 4.15 | 11 | 2.65 | 2.92e-03 |
| prostaglandin metabolism | The chemical reactions and physical changes involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. | 15 | 0.65 | 4 | 6.17 | 3.24e-03 |
| intracellular transport | The directed movement of substances within a cell. | 425 | 18.36 | 31 | 1.69 | 3.59e-03 |
| regulation of growth | Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. | 85 | 3.67 | 10 | 2.72 | 3.66e-03 |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. | 330 | 14.25 | 25 | 1.75 | 5.17e-03 |
| complement activation, classical pathway | Processes involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes. | 27 | 1.17 | 5 | 4.29 | 5.47e-03 |
| integrin-mediated signaling pathway | 50 | 2.16 | 7 | 3.24 | 5.47e-03 | |
| glucosamine metabolism | The chemical reactions and physical changes involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin. | 9 | 0.39 | 3 | 7.72 | 5.56e-03 |
| protein transport | The directed movement of proteins into, out of, within or between cells. | 354 | 15.29 | 26 | 1.70 | 6.55e-03 |
| regulation of development | Any process that modulates the frequency, rate or extent of development, the biological processes specifically aimed at the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). | 122 | 5.27 | 12 | 2.28 | 6.71e-03 |
| nerve ensheathment | The processes by which the axon of a neuron is insulated, thereby preventing dispersion of the electrical signal. | 10 | 0.43 | 3 | 6.95 | 7.69e-03 |
| regulation of cellular process | Any process that modulates the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. | 776 | 33.51 | 48 | 1.43 | 9.28e-03 |
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