Welcome to the L2L Microarray Analysis ToolA simple tool for discovering the hidden biological significance in microarray expression data. |
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| Results summary | View all lists in L2L MDB | View all genes in diab_neph_dn |
| List Name | Notes | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| ifn_beta_up | Upregulated by treatment with IFN-beta | 135 | 5.83 | 31 | 5.32 | 1.87e-14 |
| ifn_alpha_up | Upregulated by treatment with IFN-alpha | 111 | 4.79 | 28 | 5.84 | 2.66e-14 |
| ageing_brain_up | Age-upregulated in the human frontal cortex | 393 | 16.97 | 55 | 3.24 | 2.93e-14 |
| ifn_all_up | Upregulated by treatment with all three of IFN-alpha, -beta and -gamma | 73 | 3.15 | 19 | 6.03 | 1.97e-10 |
| nf90_up | Upregulated by ectopic expression of NF90 | 59 | 2.55 | 17 | 6.67 | 3.07e-10 |
| ifnalpha_both_up | Upregulated by IFNalpha treatment in both normal hepatocytes or Hep3B carcinoma cells | 36 | 1.55 | 13 | 8.36 | 1.64e-09 |
| adip_diff_cluster2 | Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) | 43 | 1.86 | 12 | 6.46 | 1.84e-07 |
| emt_up | Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 104 | 4.49 | 18 | 4.01 | 5.10e-07 |
| hypoxia_compilation_up | Compilation of upregulated genes from all hypoxia-related lists | 419 | 18.10 | 42 | 2.32 | 5.41e-07 |
| hpv31_dn | Downregulated by infection of NHEK with HPV31 | 69 | 2.98 | 14 | 4.70 | 1.28e-06 |
| ifnalpha_either_up | Upregulated by IFNalpha treatment in either normal hepatocytes or Hep3B carcinoma cells | 83 | 3.58 | 15 | 4.18 | 2.53e-06 |
| adip_vs_fibro_up | Upregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes | 55 | 2.38 | 12 | 5.05 | 3.25e-06 |
| hdaci_colon_tsa12hrs_dn | Downregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 12 | 0.52 | 6 | 11.58 | 4.78e-06 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 243 | 10.49 | 27 | 2.57 | 8.28e-06 |
| hypoxia_reg | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 60 | 2.59 | 12 | 4.63 | 8.47e-06 |
| hdaci_colon_common12hrs_dn | Downregulated in common by TSA and butyrate at 12 hours in SW260 colon carcinoma cells | 13 | 0.56 | 6 | 10.69 | 8.56e-06 |
| hdaci_colon_allbut_dn | Downregulated by butyrate at any timepoint in SW260 colon carcinoma cells | 350 | 15.12 | 34 | 2.25 | 1.19e-05 |
| hdaci_colon_allcommon_dn | Downregulated, at any timepoint, in common by butyrate and TSA in SW260 colon carcinoma cells | 36 | 1.55 | 9 | 5.79 | 1.70e-05 |
| rett_up | Upregulated by expression of mutant MeCP2 (Rett syndrome) vs. wt MeCP2 in fibroblasts | 30 | 1.30 | 8 | 6.17 | 3.01e-05 |
| hdaci_colon_tsa24hrs_up | Upregulated by TSA at 24 hrs in SW260 colon carcinoma cells | 31 | 1.34 | 8 | 5.98 | 3.90e-05 |
| tnfalpha_adip_up | Upregulated in mature, differentiated adipocytes following treatment with TNFalpha | 17 | 0.73 | 6 | 8.17 | 5.31e-05 |
| alzheimers_disease_dn | Downregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus | 1276 | 55.11 | 85 | 1.54 | 7.74e-05 |
| brca_er_neg | Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors | 859 | 37.10 | 62 | 1.67 | 7.90e-05 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 163 | 7.04 | 19 | 2.70 | 8.90e-05 |
| cmv_up | Upregulated by infection of fibroblasts with CMV | 88 | 3.80 | 13 | 3.42 | 1.04e-04 |
| hdaci_colon_tsa16hrs_dn | Downregulated by TSA at 16 hrs in SW260 colon carcinoma cells | 13 | 0.56 | 5 | 8.91 | 1.44e-04 |
| vhl_normal_up | Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2) | 230 | 9.93 | 23 | 2.32 | 1.84e-04 |
| dsrna_up | Upregulated by dsRNA (polyI:C) in IFN-null GRE cells | 48 | 2.07 | 9 | 4.34 | 1.89e-04 |
| tgfbeta_all_up | Upregulated by TGF-beta treatment of fibroblasts, at any timepoint | 145 | 6.26 | 17 | 2.71 | 1.90e-04 |
| hdaci_colon_but48hrs_dn | Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 326 | 14.08 | 29 | 2.06 | 2.29e-04 |
| heartfailure_atria_dn | Downregulated in the atria of failing hearts (DCM and ICM) compared to healthy controls | 225 | 9.72 | 22 | 2.26 | 3.43e-04 |
| tnfalpha_tgz_adip_up | Upregulated in mature, differentiated adipocytes following simultaneous treatment with troglitazone and TNFalpha | 23 | 0.99 | 6 | 6.04 | 3.47e-04 |
| hdaci_colon_alltsa_dn | Downregulated by TSA at any timepoint in SW260 colon carcinoma cells | 76 | 3.28 | 11 | 3.35 | 4.16e-04 |
| uvb_nhek1_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 372 | 16.07 | 31 | 1.93 | 4.43e-04 |
| hdaci_colon_but30min_dn | Downregulated by butyrate at 30 min in SW260 colon carcinoma cells | 66 | 2.85 | 10 | 3.51 | 5.18e-04 |
| hdaci_colon_alltsa_up | Upregulated by TSA at any timepoint in SW260 colon carcinoma cells | 232 | 10.02 | 22 | 2.20 | 5.22e-04 |
| hdaci_colon_cluster9 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) | 55 | 2.38 | 9 | 3.79 | 5.47e-04 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 266 | 11.49 | 24 | 2.09 | 6.15e-04 |
| tgz_adip_up | Upregulated in mature, differentiated adipocytes following treatment with troglitazone | 26 | 1.12 | 6 | 5.34 | 7.07e-04 |
| hdaci_compilation_up | Compilation of upregulated genes from all HDAC-inhibitor-related lists | 474 | 20.47 | 36 | 1.76 | 9.10e-04 |
| hif1_targets | Hif-1 (hypoxia-inducible factor 1) transcripional targets | 60 | 2.59 | 9 | 3.47 | 1.05e-03 |
| brca_brca1_neg | Genes whose expression is consistently negatively correlated with brca1 germline status in breast cancer - higher expression is associated with BRCA1 tumors | 112 | 4.84 | 13 | 2.69 | 1.13e-03 |
| brca1_up | Upregulated by induction of BRCA1 in EcR-293 cells | 62 | 2.68 | 9 | 3.36 | 1.33e-03 |
| hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 114 | 4.92 | 13 | 2.64 | 1.33e-03 |
| cmv_dn | Downregulated by infection of fibroblasts with CMV | 144 | 6.22 | 15 | 2.41 | 1.50e-03 |
| tgfbeta_cluster1_up | Upregulated by TGF-beta treatment of fibroblasts (Fig. 1 Cluster 1) | 30 | 1.30 | 6 | 4.63 | 1.57e-03 |
| ni2_mouse_up | Upregulated by nickel(II) in sensitive A/J mouse lung tissue | 52 | 2.25 | 8 | 3.56 | 1.66e-03 |
| adip_vs_preadip_up | Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 53 | 2.29 | 8 | 3.49 | 1.88e-03 |
| atria_up | Upregulated in the atria of healthy hearts, compared to venticles | 373 | 16.11 | 29 | 1.80 | 1.90e-03 |
| dac_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells | 43 | 1.86 | 7 | 3.77 | 2.29e-03 |
| cis_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to cisplatin, compared to parent chemosensitive lines | 7 | 0.30 | 3 | 9.92 | 2.47e-03 |
| lvad_heartfailure_dn | Downregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 46 | 1.99 | 7 | 3.52 | 3.41e-03 |
| il1_cornea_dn | Downregulated in corneal fibroblasts after interleukin-1 treatment | 129 | 5.57 | 13 | 2.33 | 3.99e-03 |
| aged_mouse_muscle_up | Upregulated in the gastrocnemius muscle of aged adult mice (30-month) vs. young adult (5-month) | 37 | 1.60 | 6 | 3.75 | 4.76e-03 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 148 | 6.39 | 14 | 2.19 | 5.09e-03 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 89 | 3.84 | 10 | 2.60 | 5.10e-03 |
| oxstress_rpetwo_dn | Downregulated by two of H2O2, HNE and t-BH in retinal pigment epithelium cells (Tables 3-5) | 262 | 11.32 | 21 | 1.86 | 5.26e-03 |
| brca_er_pos | Genes whose expression is consistently positively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-positive tumors | 478 | 20.64 | 33 | 1.60 | 6.20e-03 |
| alzheimers_disease_up | Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus | 1790 | 77.31 | 100 | 1.29 | 6.36e-03 |
| calres_mouse_neocortex_up | Upregulated in the neocortex of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls | 92 | 3.97 | 10 | 2.52 | 6.44e-03 |
| uvb_scc_up | Upregulated by UV-B light in squamous cell carcinoma cells | 186 | 8.03 | 16 | 1.99 | 7.18e-03 |
| hypoxia_fibro_up | Upregulated by hypoxia in normal fibroblasts from both young and old donors | 29 | 1.25 | 5 | 3.99 | 7.49e-03 |
| h2o2_csbrescued_up | Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1) | 96 | 4.15 | 10 | 2.41 | 8.63e-03 |
| adip_human_dn | Down-regulated in primary human adipocytes, versus preadipocytes | 42 | 1.81 | 6 | 3.31 | 8.94e-03 |
| aged_mouse_hypoth_dn | Down-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls | 55 | 2.38 | 7 | 2.95 | 9.23e-03 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 401 | 17.32 | 28 | 1.62 | 9.50e-03 |
| hdaci_colon_but24hrs_dn | Downregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 313 | 13.52 | 23 | 1.70 | 1.00e-02 |
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