Hematopathology Laboratory
CD Antigens Useful for Hematopathology
See reference 1
| Cluster Designation |
Antibodies, Other Names |
Cells Expressing |
Function |
| CD1 |
T6, Leu 6 |
Dendritic reticular cells, Langerhans cell histiocytosis,
few lymphoblastic lymphomas |
|
| CD2 |
T11, 9.6 |
T cells, NK cells |
LFA-3 (CD58) ligand |
| CD3 |
T3, Leu 4 |
T cells |
T cell antigen receptor structure, signal transduction |
| CD4 |
T4, Leu 3a |
Helper T cells |
MHC class II coreceptor, HIV receptor |
| CD5 |
T1, 10.2 |
T cells, B cell subset, CLL, mantle cell lymphoma |
T cell activation, CD72 ligand |
| CD7 |
3A1, Leu 9 |
T cells, NK cells, early myeloid cells, some AMLs |
T and NK cell activation |
| CD8 |
T8, Leu 2a |
Cytotoxic and suppressor T cells, NK cells |
MHC class I coreceptor |
| CD10 |
J5, CALLA |
Early B cells |
Neutral endopeptidase |
| CD11b |
MAC-1, CR1, Mo1, OKM1 |
Monocytes, granulocytes |
Cell adhesion molecule, part of CD11/CD18 integrin |
| CD11c |
Leu M5 |
Granulocytes, monocytes, hairy cell leukemia |
Cell adhesion molecule, part of CD11/CD18 integrin |
| CD13 |
My7, Leu M7 |
Myeloid cells |
Aminopeptidase N |
| CD14 |
Mo2, My4 |
Monocytes |
|
| CD15 |
Leu M1, My1 |
Granulocytes, Reed-Sternberg cells, endothelial cells |
Lewisx antigen, cell adhesion and phagocytosis |
| CD16 |
Leu 11a |
NK cells, granulocytes |
Fc gamma RIII (IgG receptor) |
| CD19 |
B4, Leu 12 |
B cells |
B cell activation |
| CD20 |
B1, Leu 16 |
B cells |
Ca++ channel, B cell activation |
| CD22 |
B3, Leu 14 |
B cells |
Cell adhesion molecule |
| CD23 |
B6 |
Activated B cells, CLL |
Fc epsilon RII (IgE receptor) |
| CD25 |
Tac |
Activated T cells, activated B cells, hairy cell leukemia,
ATL/L |
Interleukin 2 receptor alpha chain |
| CD28 |
9.3 |
T cells |
Delivery of second signal during T cell activation, B7 (CD80/CD86)
ligand |
| CD29 |
4B4 |
Activated T cells |
Cell adhesion molecule |
| CD30 |
Ki-1, Ber-H2 |
Activated T cells, Reed-Sternberg cells, anaplastic large
cell lymphoma, germ cell tumors |
Growth factor receptor (similar to TNF receptor) |
| CD33 |
My9 |
Myeloid cells |
Sialic acid adhesion molecule |
| CD34 |
HPCA-2, My10 |
Progenitor cells |
|
| CD38 |
T10 |
Lymphoid progenitor cells, plasma cells |
Leukocyte activation |
| CD40 |
|
B cells |
Growth factor receptor, B cell activation |
| CD41 |
|
Megakaryocytes |
gpIIb, cell adhesion molecule with CD61, fibrinogen/fibronectin
receptor |
| CD42b |
|
Megakaryocytes |
gpIb, vWF receptor |
| CD43 |
Leu 22 |
T cells, myeloid cells, some B cell lymphomas |
|
| CD45 |
T200, LCA |
Panhematopoietic |
Signal transduction: tyrosine phosphatase |
| CD45RA |
2H4 |
B cells, naïve T cells |
Signal transduction: tyrosine phosphatase |
| CD45RO |
UCHL-1 |
Memory T cells |
Signal transduction: tyrosine phosphatase |
| CD54 |
ICAM-1 |
Endothelium, activated cells |
Cell adhesion molecule, receptor for CD11/CD18 integrin |
| CD55 |
DAF |
Most cells |
Inhibits complement activation |
| CD56 |
NKH-1, Leu 19, N-CAM |
NK cells |
Cell adhesion molecule |
| CD57 |
HNK-1, Leu 7 |
NK cells |
|
| CD59 |
MIRL |
Many hematopoietic cells, decreased or absent in PNH |
Blocks complement activity |
| CD61 |
|
Megakaryocytes |
gbIIIa, cell adhesion molecule with CD41, fibrinogen receptor |
| CD62P |
PADGEM, P-selectin, GMP-140 |
Activated platelets |
Cell adhesion molecule |
| CD71 |
T9 |
Erythroid, lymphoid precursors |
Transferrin receptor |
| CD80 |
B7-1 |
B cells, dendritic cells |
T cell costimulatory molecule |
| CD86 |
B7-2 |
B cells, dendritic cells |
T cell costimulatory molecule |
| CD95 |
APO-1, Fas |
T cells |
Transmits apoptosis signal (similar to TNF receptor) |
| CD103 |
HML-1 |
Intestinal epithelial lymphocytes |
|
| CD122 |
|
T cells |
Interleukin 2 receptor beta chain |
Other Antigens Useful for Hematopathology
| Antigen |
Antibodies, Other Names |
Cells Expressing |
Function |
| HLA-DR |
Ia, 7.2 |
B cells, monocytes, myeloid progenitors, activated T cells |
Class II MHC, antigen presentation |
| IgM heavy chain (mu) |
|
Naïve B cells |
Antigen recognition, B cell activation |
| IgG heavy chain (gamma) |
|
Antigen-experienced B cells |
Antigen recognition, B cell activation, humoral immunity |
| IgD heavy chain (delta) |
|
Naïve B cells |
Antigen recognition, B cell activation |
| IgA heavy chain (alpha) |
|
Antigen-experienced B cells |
Antigen recognition, B cell activation, mucosal immunity |
| IgE heavy chain (epsilon) |
|
Antigen-experienced B cells |
Antigen recognition, B cell activation, hypersensitivity
reactions |
| Kappa light chain |
|
B cells |
Antigen recognition, B cell activation |
| Lambda light chain |
|
B cells |
Antigen recognition, B cell activation |
| TdT |
|
Immature lymphoid cells |
Ig and TCR rearrangement |
| MiB-1/Ki-67 |
Dako-PC |
Proliferating cells |
|
Hematopathology Home
Table of Contents
Last updated: 6/22/00
|
