Hematopathology Laboratory
Diagnosis of Acute Leukemia
| Classification |
Cytochemistry |
Immunophenotype |
Other Markers |
|
| General Markers |
Myeloid Markers |
B Cell Markers |
T Cell Markers |
Platelet Marker |
|
| MPO |
NSE |
PAS |
HLA-DR |
CD34 |
CD13 |
CD33 |
CD10 |
CD19 |
kappa/
lambda |
CD2 |
CD5 |
CD7 |
CD61 |
|
| AML M0 (undifferentiated) |
- |
- |
- |
+ |
+/- |
+ |
+/- |
- |
- |
- |
- |
- |
-/+ |
- |
|
|
| AML M1 (myeloblastic without maturation) |
+ |
- |
- |
+ |
-/+ |
+ |
+/- |
- |
- |
- |
- |
- |
-/+ |
- |
|
|
| AML M2 (myeloblastic with maturation) |
+ |
- |
- |
+ |
-/+ |
+ |
+/- |
- |
- |
- |
- |
- |
-/+ |
- |
|
|
| AML M3 (promyelocytic) |
++ |
- |
- |
- |
- |
+ |
+ |
- |
- |
- |
- |
- |
- |
- |
t(15;17) |
|
| AML M4 (myelomonocytic) |
+ |
+ |
+/- |
+ |
- |
+ |
+ |
- |
- |
- |
- |
- |
- |
- |
inv(16) in M4-Eo |
|
| AML M5 (monoblastic/monocytic) |
- |
++ |
+/- |
+ |
- |
+ |
+ |
- |
- |
- |
- |
- |
- |
- |
Occ. CD14 |
|
| AML M6 (erythroleukemia) |
- |
- |
+
("chunky") |
+/- |
+/- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
Glycophorin A, CD71 |
|
| AML M7 (megakaryoblastic) |
- |
- |
+/- |
+ |
+/- |
+/- |
+/- |
- |
- |
- |
- |
- |
- |
+ |
|
|
| Pre-B ALL |
- |
- |
-/+
("string of pearls") |
+ |
+/- |
- |
- |
+ |
+ |
- |
- |
- |
- |
- |
TdT, cytoplasmic mu, IgH rearranged |
|
| Burkitt's leukemia/lymphoma (FAB type L3) |
- |
- |
- |
+ |
- |
- |
- |
+/- |
+ |
+
(clonal) |
- |
- |
- |
- |
t(8;14), t(2;8), t(8;22) |
|
| T lymphoblastic leukemia/lymphoma |
- |
- |
-/+
("string of pearls") |
+/- |
- |
- |
- |
- |
- |
- |
+/- |
+/- |
+ |
- |
TdT, CD1-/+, CD3-/+, CD4,8 double positive or double negative |
|
| Adult T cell leukemia/lymphoma |
- |
- |
- |
+ |
- |
- |
- |
- |
- |
- |
+ |
+ |
- |
- |
CD3, CD4, CD25, HTLV-I |
|
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Last updated: 6/22/00
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