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John R. Hess, MD, MPH, FACP, FAAAS

photo Dr. John Hess

Professor, Department of Laboratory Medicine
Adjunct Professor, Hematology
Medical Director, Transfusion Service
Harborview Medical Center

Contact Information

Harborview Medical Center
325 North Ninth Ave., Box 359743
Seattle, WA 98104
Tel: 206.744.6575
Fax: 206.744.6565

Personal Biography

Raised in Spokane, Dr. Hess attended medical school at the UW. He then spent thirty years in the US military and Public Health Service and a dozen years at the University of Maryland before returning to Seattle to develop transfusion systems for the University of Washington. His research involves both the development of better blood storage systems and hemorrhage control devices and the conduct of large human trials testing better ways to use blood products. He served on the WHO Expert Panel for Blood Transfusion Medicine from 2006‑2012.

Education and Training

  • BA, General Studies, Washington State University, Pullman, WA, June 1963
  • MD, University of Washington, Seattle, WA, June 1972
  • MPH, University of Hawaii at Manoa, Honolulu, HI Dec 1979
  • Internship, Internal Medicine, Presbyterian‑University Hospital, Pittsburgh PA, June 1973
  • Residency, Internal Medicine, Tripler Army Medical Center, Honolulu, HI, June 1975‑1977
  • Fellowship, Adult Hematology and Medical Oncology, Fitzsimons Army Medical Center, Aurora, CO June 1982‑1985

Clinical Interests

Transfusion Medicine, Blood Coagulation, Apheresis, Trauma Care, Public Health, International Public Health

Current Research

Red Cell Storage, Hemorrhage Control
Clinical Trials of Blood Products

Selected Publications

  1. Hess JR, B, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, Mackway‑Jones K, Parr MJ, Rizoli SB, Yurioka T, Hoyt DB, Bouillon B. The coagulopathy of trauma: A review of mechanisms. J Trauma 2008; 65:748‑754.
  2. Hess JR, Lindell AL, Stansbury LG, Dutton RP, Scalea TM. The prevalence of abnormal results of conventional coagulation tests on admission to a trauma center. Transfusion 2009; 49:34‑39.
  3. Slichter SJ, Kaufman RM, Assmann SF, McCullough J, Triulzi DJ, Strauss RG, Gernsheimer TB, Ness PM, Brecher ME, Josephson CD, Konkle BA, Woodson RD, Ortel TL, Hillyer CD, Skerrett DL, McCrae KR, Sloan SR, Uhl L, George JN, Aquino VM, Manno C, McFarland JG, Hess JR, Leissinger C, Granger S. Dose of Prophylactic platelet transfusion and prevention of hemorrhage. N Engl J Med 2010; 362:600‑613.
  4. Hess JR. Red cell changes during storage. Transfus Apher Sci 2010; 43:51‑59.
  5. Dowling MB, Kumar R, Keibler MA, Hess JR, Bochicchio GV, Raghavan SR. A self‑assembling hydrophobically modified chitosan capable of reversible hemostatic action. Biomaterials. 2011; 32:3351‑3357.
  6. Hess JR, for the BEST Collaborative. Scientific problems in the regulation of red cell products. Transfusion 2012; 52:1827‑1835.
  7. Hess JR. Measures of stored red blood cell quality. Vox Sang 2014; 107:1‑6.
  8. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BRH, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet J‑F, Hoyt DB, Pearson GD, Leroux B, van Belle G for the PROPPR Study Group. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs. a 1:1:2 ratio and mortality in patients with severe trauma: The PROPPR Randomized Clinical Trial. JAMA. 2015;313(5):483‑494.

Honors and Awards

  • Legion of Merit, US Army 2001
  • Invention of the Year, University of Maryland, 2008

Last updated: 08/09/2016

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