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HomeFaculty › Kerstin Edlefsen, MD

Kerstin Edlefsen, MD

photo Dr. Kerstin Edlefsen, MD

Assistant Professor;
Associate Director, Hematopathology Division
Assistant Director, UWMC Bone Marrow Service

Contact Information

University of Washington
Department of Laboratory Medicine
Seattle Cancer Care Alliance Mail Stop G7-800
825 Eastlake Ave. E.
Seattle, WA 98109
Tel: 206.288.7042
Fax: 206.288.7127

Personal Biography

Dr. Edlefsen is a Seattle native, who lives in Wallingford with her husband and two children. She is a pathologist with expertise in hematopathology. She enjoys bringing diverse diagnostic modalities to the diagnosis and monitoring of leukemia and lymphoma, and collaborating with clinical colleagues to provide state-of-the-art cancer care.

Education and Training

  • Hematopathology Fellow, University of Washington School of Medicine, Seattle, WA, 2008-2009
  • Surgical Pathology Fellow/Co-Chief Resident, Anatomic Pathology, University of Washington School of Medicine, Seattle, WA, 2006-2007
  • Resident in Pathology and Laboratory Medicine, University of Washington School of Medicine, Seattle, WA, 2002-2006
  • MD, University of Washington School of Medicine, Seattle, WA, 2002
  • BA/BS, The Evergreen State College, Olympia, WA, 1997

Clinical Interests

  • Hematopathology
  • Morphologic diagnosis of leukemia and lymphoma
  • Flow Cytometry
  • Non-neoplastic disorders of bone marrow and lymph nodes

Research Interests

  • Lymphomagenesis
  • Epidemiology of leukemia and lymphoma
  • Preneoplastic conditions in leukemia/lymphoma including monoclonal B-cell lymphocytosis
  • Aging and immune function

Current Research

Dr. Edlefsen's primary research interests lie in understanding the pathogenesis of mature B cell neoplasms. She is particularly interested in understanding the relationship between clonal lymphocyte expansions and the development of lymphoma, with an emphasis on chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and mantle cell lymphoma. Specific research endeavors include:

  • Exploring the relationship between serum markers of chronic immune dysregulation and prospective risk of B cell lymphoma
  • Flow cytometric detection of epidemiologically significant B and T lymphocyte subsets and their relationship to health and aging in elderly women
  • Relationship between monoclonal B cell lymphocytosis (MBL), markers of immune function, peripheral blood counts, and other factors in elderly women

Selected Publications

  1. De Roos AJ, Mirick D, Edlefsen KL, LaCroix AZ, Kopecky KJ, Madeleine MM, Magpantay L, Martinez-Maza O. Markers of B-Cell Activation in Relation to Non-Hodgkin Lymphoma. Cancer Research, 2012 Sep 15; 72(18):4733-43.
  2. Linden M, Gopal A, and Edlefsen KL. Case report: Acute appendicitis in a man undergoing therapy for mantle cell lymphoma. Case Report Hematol. 2012;2012:868151 doi: 10.1155/2012/868151.
  3. Edlefsen KL, Greisman HA, Yi HS, Mantei KM, Fromm JR. Early lymph node involvement by mantle cell lymphoma limited to the germinal center: Report of a case with a novel 'follicular in-situ' growth pattern. Am J Clin Pathol. 2011 Aug; 136(2):276-281.
  4. Edlefsen KL, Jackson RD, Prentice RL, Janssen I, Rajkovic A, O'Sullivan MJ, Anderson G. The effects of postmenopausal hormone therapy on serum estrogen, progesterone, and sex hormone-binding globulin levels in healthy postmenopausal women. Menopause 2010; 17(33):622-629.
  5. Edlefsen KL, Tait JF, Wener MH, Astion M. Utilization and Diagnostic Yield of Neurogenetice Testing at a Tertiary Care Facility. Clinical Chemistry 2007;53(6): 1016-22.

Honors and Awards

  • Strandjord-Clayson Award, University of Washington Department of Laboratory Medicine, 2006
  • Alpha Omega Alpha, 2002

Last updated: 1/22/2013

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