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HomeFaculty › Lisa Frenkel, MD

Lisa Frenkel, MD

photo Dr. Lisa Frenkel

Professor;
Pediatrics, Division of Infectious Diseases;
Laboratory Medicine, Division of Virology;
Adjunct Professor, Department of Global Health;
Interim Co-Director, Center for Childhood Infections & Prematurity Research, Seattle Children's Research Institute

Contact Information

1900 9th Ave.
Seattle WA 98101
Tel: 206.987-5140
Fax: 206.884.7311
Email: lfrenkel

Personal Biography

Lisa is the mother of two adult children and enjoys hiking and Nordic skiing with her husband and friends.

Education and Training

  • Universidad de Costa Rica, San Jose, 1976-77
  • BA, Kansas University, Lawrence, Kansas, 1973-77
  • MD, Kansas University Medical School, Kansas City, Kansas, 1977-81
  • Pediatric Residency, University of California, Los Angeles, California, 1981-84
  • Infectious Disease Fellowship, University of California, Los Angeles, California, 1984-87

Clinical Interests

  • Viral infections in children and pregnant women that can be transmitted to the fetus/infant.

Research Interests

Dr. Frenkel's research focuses on understanding HIV-1-drug-resistance, prevention of mother-to-child-transmission, characteristics of HIV-1 that is transmitted, and mechanisms that allow HIV-1 infection to persist despite suppressive antiretroviral therapy. Her group is also working to develop and transfer practical and economical assays to facilitate HIV-1 diagnosis in infants, and to monitor antiretroviral treatment and drug-resistant mutants in resource-poor communities. Their projects include collaborative studies with colleagues in Kenya, Peru, Thailand, South Africa, the USA and Zimbabwe.

Current Research

  • 2 R37 AI047734 National Institutes of Health, 07/05/05-03/31/15 :
    "Occurrence and Outcome of Dual HIV-1 Infection"
    Investigations of the link between dual HIV-1 infection and accelerated disease progression. (SCH #412660220201)
    Role: Co-investigator
  • U01 AI068632 National Institutes of Health, 07/01/06-05/31/13:
    "International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group" – Virology Lab
    Investigate HIV-1 pathogenesis and develop virologic assays for the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network. (SCH #412660250601)
    Role: PI
  • NO1-DK-8-0001 National Institutes of Health, 12/16/07-12/31/13
    "International and Domestic Pediatric and Maternal HIV Studies Coordinating Center" (Westat)
    Clinical trials site to advance the interruption of mother to infant HIV-1 transmission, and improve prevention and treatment of HIV-1 infection for children and adolescents internationally as well as within the United States. (SCH #412660060801 & 60901)
    Role: PI
  • 1 R01 AI078802National Institutes of Health, 04/01/09-06/30/13 0.06 calendar months NIH $57,495 annual DC
    "Low-frequency HIV-1 Drug Resistance Mutations in Primary HIV-1 Infection" (PIC HIV)
    This project is proposed to define the clinical and public health implications of low-frequency HIV-1 drug resistance mutations. (SCH #412660310101)
    Role: Co-Investigator
  • 1 R21 AI084699 National Institues of Health, 07/01/09-06/30/13
    "Quantification and Dynamics of HIV-1 Drug-Resistant Mutants by Pyrosequencing"
    Validation of quantification of NVP-and ZDV-mutants by a sensitive point-mutation oligonucleotide ligation assay (OLA) by comparison to massive parallel pyrosequencing. Study will also provide insight into the dynamics of drug-resistant viruses relevant to clinical management of HIV-1 infected women and infants. (SCH #412660320101)
    Role: PI
  • 2 P01 AI057005-06A2 National Institues of Health, 07/15/10-06/30/15
    Immunologic and Virologic Events in Early HIV Infection (SEAPIP)
    Single-genome-amplification of virus from HIV-infected Africans and their newly infected partners to better understand heterosexual transmission of HIV. (SCH #412660380201)
    Role: Investigator
  • 1 R01 AI091550 National Institues of Health, 01/21/11-12/31/15 0.91 calendar months NIH / NIAID $283,157 annual DC
    "HIV-1 evolution in the female genital tract and trafficking in the blood"
    This project investigates if monotypic (identical) HIV env sequences in the uterine cervix result from proliferation of infected cells or from bursts of viral replications. She will also determine if whole monotypic HIV genomes include replication competent viruses. (SCH $412660400201)
    Role: PI
  • 2 T32 HD07233-31 National Institues of Health, 05/01/12-04/30/17
    Academic Pediatric Infectious Disease – Renewal
    This program seeks to train pediatricians to contemporary molecular biology so they will be equipped to answer questions relevant to infectious disease in infants and children.
    Role: PI
  • 1 R01 AI100037 National Institues of Health, 04/01/12-03/31/15
    "Drug-resistance testing in Kenya to improve ART suppression of HIV replication"
    A randomized-controlled trial of oligonucleotide ligation assay detection of HIV-drug-resistance pre-ART will be conducted to assess effect on rates of ART-associated suppression of viral replication. In addition, we will analyze issues related to transfer of technology and will model the cost-effectiveness of the OLA in ART management.
    Role: PI
  • U01 AI068632 National Institues of Health, 09/01/12-05/31/13
    "International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group"
    "Network Executive Committee on the IMPAACT Leadership Core" NICHD Scientific Oversight Committee representative.
    Role: PI

Selected Publications

  1. Micek MA, Blanco AJ, Beck IA, Dross S, Matunha L, Montoya P, Seidel K, Gantt S, Matediane E, Jamisse L, Gloyd S, Frenkel LM. Nevirapine Resistance by Timing of HIV Type 1 Infection in Infants Treated with Single-Dose Nevirapine. Clin Infect Dis. 2010; 5p(10):1405-1414. PMCID: PMC3038662.
    [PubMed]
  2. Gantt S, Carlsson J, Heath L, Bull ME, Shetty AK, Mutsvangwa J, Musingwini G, Woelk G, Zijenah LS, Katzenstein DA, Mullins JI, Frenkel LM. Genetic analyses of HIV-1 env sequences demonstrate limited 1 compartmentalization in breast milk and suggest viral replication within the breast that increases with mastitis. J Virol. 2010; 84(20):10812-10819. PMID: 20660189. PMCID: PMC2950573.
    [PubMed]
  3. Micek MA, Blanco AJ, Carlsson J, Beck IA, Dross S, Matunha L, Seidel K, Montoya P, Tantt S, Matediana E, Jamisse L, Gloyd S, Frenkel LM. 2011. Effects of short-course zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine. J Infect Dis 205(12):1811-1815. PMCID: PMC3415891.
    [PubMed]
  4. Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, Tappero JW, Bukusi EA, Cohen CR, Katabira E, Ronald A, Tumwesigye E, Were E, Fife KH, Kiarie J, Farquhar C, John-Stewart G, Kakia A, Odoyo J, Mucunguzi A, Nakku-Joloba E, Twesigye R, Ngure K, Apaka C, Tamooh H, Gabona F, Mujugira A, Panteleeff D, Thomas KK, Kidoguchi L, Krows M, Revall J, Morrison S, Haugen H, Emmanuel-Ogier M, Ondrejcek L, Coombs RW, Frenkel L, Hendrix C, Bumpus NN, Bangsberg D, Haberer JE, Stevens WS, Lingappa JR, Celum C for the Parterns PrEP Study Team. 2012. Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women. N Engl J Med 367(5):399-410. PMID: 22784037.
    [PubMed]
  5. Wagner T, McKernan J, Tobin N, Tapia K, Mullins J, Frenkel L. 2012. An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells. J Virol. 2013, in press. PMCID: PMC Journal – In Process.
    [PubMed]
  6. Bull ME, Heath LM, McKernan-Mullin JL, Kraft KM, Acevedo L, Hitti JE, Cohn SE, Tapia KA, Holte SE, Dragavon JA, Coombs RW, Mullins JI, Frenkel LM. 2012. Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses, but genital lineages do not persist over time.J Infect Dis. 2013 Jan 11. [Epub ahead of print] PMID: 23315326 PMC Journal – In Process.
    [PubMed]
  7. Additional publications by Lisa Frenkel: http://depts.washington.edu/idimmweb/facultyMember.php?sort=8

 

Honors and Awards

  • Russel Haden Medal for medical student research, Kansas University, 1978
  • 1st William F. Friedman Lectureship, UCLA, 1994
  • Member, 4-year term, NIH AARR-3/ADDT Study Section, 2002-2006
  • Member, NIH-NIAID AIDS Research Review Committee (AIDSRRC), 2007-2011 Extraordinary Professor in the Department of Immunology, Faculty of Health Sciences, University of Pretoria, 2010-2012
  • Member (extended 4y + 2 yr) NIH-NIAID AIDS Research Review Committee (AIDSRRC), 2011-2013
  • Outstanding Mentor Award of 2011, University of Washington, Dept. Pediatrics, 2011

Last updated: 1/29/2013

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