Keith Jerome, MD, PhD
Head, Virology Division, UW Lab Medicine;
Director, UW Molecular Virology Laboratory;
Director, UW Virology Laboratory at Seattle Children's Hospital;
Associate Member, Fred Hutchinson Cancer Research Center
Fred Hutchinson Cancer Research Center 1100 Fairview Avenue North, E5-110 Seattle, WA 98109
Dr. Jerome joined the faculty at the University of Washington in 1998, and joined the faculty at the Fred Hutchinson Cancer Research Center in 2004. His research focuses on the biology of chronic viral infections. He has published extensively on pathogen-host interactions and immune evasion by herpesviruses, and is now pioneering the use of DNA-editing endonucleases as a potentially curative therapy for HIV, hepatitis B, human papillomavirus, and herpesvirus infections. He currently serves as co-PI and NIH contact PI for the Hutchinson Center’s Martin Delaney Collaboratory working toward a cure for HIV disease.
In addition to his basic research efforts, Dr. Jerome leads the diagnostic virology program at the University of Washington. Under his guidance the program has designed and implemented molecular testing assays for a wide variety of human viruses, including hepatitis B and C, enterovirus , BK virus, and cytomegalovirus. The laboratory provides diagnostic support for stem cell transplant and other patients in the Pacific Northwest, and throughout the country through its reference testing services.
Education and Training
- Georgetown College, B.S., Chemistry, summa cum laude, 1985
- Duke University, Ph.D., Microbiology and Immunology, 1992
- Duke University, M.D., May 1993
- Resident Physician, Department of Pathology, University of Washington, 1993-1995
- Resident Physician, Department of Laboratory Medicine, University of Washington, 1995-1997
- Senior Fellow, Virology Division, Department of Laboratory Medicine, University of Washington, 1997-1998
- Real-time PCR
- Automation of nucleic acid extraction
- Diagnosis of disease caused by herpesviruses, enterovirus, JC and BK viruses, parvovirus B19, and hepatitis viruses
- Clinically important persistent and latent viral infections
- Curative therapies for latent viral infections
- Targeted Modification of Host and Proviral DNA to Treat Latent HIV Infection
The goal of this multi-project, multi-core effort is to develop DNA targeting proteins that can modify integrated HIV provirus or host cell receptors required for HIV infection, and to test these proteins in a preclinical model of HIV infection.
- Dendritic Cell-Based Delivery for Genetic Therapy of Latent HIV Infection
Goal: to evaluate the hypothesis that dendritic cells might constitute an ideal vehicle for delivery of HIV-specific homing endonucleases to latently infected memory T cells comprising the latent viral reservoir.
- Hepatitis B Research Network Central Lab
The molecular Virology Laboratory will serve as the central virology laboratory for the HBRN, a multicenter trial evaluating natural history and therapeutic response to antivirals in HBV infection.
- Homing Endonucleases for the Cure of Latent HIV Infection
Goals: to develop a set of HIV-specific homing endonucleases (HEs) recognizing conserved sequences within the HIV genome, and evaluate their ability to disrupt integrated HIV provirus.
- Homing Endonucleases for the Treatment of Latent Viral Infections in Humans
Goals: to develop small animal models and reporter constructs for latent HSV infections and to test the efficacy of homing endonucleases for cure of HSV infection in these models.
- HP Kiem, KR Jerome, SG Deeks, and JM McCune. Hematopoietic stem cell-based gene therapy for HIV disease. Cell Stem Cell. 12.2011.
- DD Sloan and KR Jerome, Herpes simplex virus remodels T cell receptor signaling resulting in p38-dependent selective synthesis of interleukin-10. Journal of Virology. 81:12504-12514. 2007.
- M Aubert, M Yoon, DD Sloan, PG Spear, and KR Jerome. The virological synapse facilitates herpes simplex virus entry into T cells. Journal of Virology. 83:6171-6183. 2009.
- M Aubert, BY Ryu, L Banks, DJ Rawlings, AM Scharenberg, and KR Jerome. Successful targeting and disruption of an integrated reporter lentivrus using the engineered homing endonuclease Y2 I-Anil. PLoS ONE. 6(2): e16825.
- J Schiffer, M Aubert, ND Weber, E Mintzer, D Stone, KR Jerome, Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections. Journal of Virology. 86(17):8920-8936.2012.
Honors and Awards
- American Herpes Foundation Research Award, 2002
- American Society for Microbiology Dade-Microscan Young Investigator Award, 2000
- National Foundation for Infectious Diseases-Astra Young Investigator Grant, 1999-2000
- Paul E. Strandjord Young Investigator Award, 1998
- Paul E. Strandjord Young Investigator Award, 1997
- National Foundation for Infectious Diseases Postdoctoral Fellowship, 1996-1997
- NIH Research Award for Clinical Trainees, 1994 o Medical Scientist Training Program, Duke University, 1987-1993
- Immunology Departmental Fellowship, Duke University, 1987-1992
- Dean's Honor Award (to the outstanding graduating senior of Georgetown College), 1985
Related Labs & Projects
- Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Institute
- defeatHIV, The Delaney Cell and Genome Engineering Initiative
- University of Washington, Department of Laboratory Medicine, Virology Division
Last updated: 12/31/2012