Department of Laboratory Medicine
University of Washington
 
Clinical assay interference and limitations

Methodology: Stago STA LIA D-dimer assay

This assay is reported in ug/mL of fibrinogen equivalent units (FEU): 1 ug/mL of D-dimer is equal to 1 ug/mL of fibrin(ogen) converted to D-dimer.

Fibrinogen degradation product concentrations greater than 15 ug/ml may lead to an over-estimation of the D-dimer level. The presence of rheumatoid factor at a level greater than 50IU/ml may lead to an over-estimation of the D-dimer level. The extremely rare presence of anti-bovine albumin in certain subjects may lead to an over-estimation of D-dimer level.
Specimens from patients who have received preparations of mouse monoclonal antibodies for diagnosis or therapy may contain human anti-mouse antibodies (HAMA). Such specimens may lead to an over-estimation of the D-dimer level. Please contact the Laboratory Medicine Resident on call 598-6190 if you have questions about the D-dimer level in any patient that has received preparations of mouse monoclonal antibodies.

Reference: Stago STA Immuno-turbidometric D-dimer assay package insert, 23296 ABC ­ Revised September 1997











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