Department of Laboratory Medicine
University of Washington
Clinical assay interference and limitations
Homocysteine [HCY]
Methodology: Abbott Axsym Homocysteine Immunoassay
Specimens from patients who have received preparations of mouse monoclonal antibodies for diagnosis or therapy may contain human anti-mouse antibody (HAMA). HAMA present in serum or plasma specimens, may interfere in immunoassays which utilize mouse monoclonal antibodies. These specimens should not be assayed with the AxSYM homocysteine assay.
S-adenosyl-methionine is an antidepressant whose molecular form is similar to S-adenosyl-homocysteine. Therapeutic levels of this drug may interfere with the AxSYM Homocysteine assay.
The following drugs may elevate levels of homocysteine: methotrexate, carbamazepine, phenytoin, nitrous oxide, and 6-azauridine triacetate.
Reference range data for children and adolescents
are not confirmed. The concentrations were lowest in younger children
and increased with age. The suggested reference ranges (Am J Clin
Nutr 1999; May; 69: 968 972) are:
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