| Vermulst M, Bielas JH, Loeb LA. Quantification of random mutations in the mitochondrial genome. Methods. 2008 Dec;46(4):263-8. | |
| Chen CY, Guo HH, Shah D, Blank A, Samson LD, Loeb LA. Substrate binding pocket residues of human alkyladenine-DNA glycosylase critical for methylating agent survival. DNA Repair (Amst). 2008 Oct 1;7(10):1731-45. | |
| Compton SA, Tolun G, Kamath-Loeb AS, Loeb LA, Griffith JD. The Werner Syndrome Protein Binds Replication Fork and Holliday Junction DNAs as an Oligomer. J Biol Chem. 2008 Sep 5;283(36):24478-83. | |
| Loeb LA, Harris CC. Advances in chemical carcinogenesis: a historical review and prospective. Cancer Res. 2008 Sep 1;68(17):6863-72. | |
| Loeb LA, Monnat RJ Jr. DNA polymerases and human disease. Nat Rev Genet. 2008 Aug; 9(8):594-604. | |
| Loeb LA, Bielas JH, Beckman RA. Cancers exhibit a mutator phenotype: clinical implications. Cancer Res. 2008 May 15;68(10):3551-7. | |
| Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet. 2008 Apr;40(4):392-4. | |
| Camps M, Herman A, Loh E, Loeb LA. Genetic constraints on protein evolution. Crit Rev Biochem Mol Biol. 2007 Sep-Oct;42(5):313-26. | |
| Venkatesan RN, Treuting PM, Fuller ED, Goldsby RE, Norwood TH, Gooley TA, Ladiges WC, Preston BD, Loeb LA. Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis. Mol Cell Biol. 2007 Nov;27(21):7669-82. | |
| Kamath-Loeb AS, Lan L, Nakajima S, Yasui A, Loeb LA. Werner syndrome protein interacts functionally with translesion DNA polymerases. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10394-9. | |
| Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet. 2007 Apr;39(4):540-3. | |
| Bielas JH, Venkatesan RN, Loeb LA. LOH-proficient embryonic stem cells: a model of cancer progenitor cells? Trends Genet. 2007 Apr;23(4):154-7 | |
| Loh E, Choe J, Loeb LA. Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I. J Biol Chem. 2007 Apr 20;282(16):12201-9. | |
| Loeb LA, Bielas JH. Limits to the Human Cancer Genome Project? Science. 2007 Feb 9;315(5813):762. | |
| Bielas JH, Loeb KR, Rubin BP, True LD, Loeb LA. Human cancers express a mutator phenotype. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18238-42. | |
| Glick E, White LM, Elliott NA, Berg D, Kiviat NB, Loeb LA. Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin. Int J Cancer. 2006 Nov 1;119(9):2225-7. | |
| Beckman RA, Loeb LA. Efficiency of carcinogenesis with and without a mutator mutation. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14140-5. | |
| Venkatesan RN, Bielas JH, Loeb LA. Generation of mutator mutants during carcinogenesis. DNA Repair (Amst). 2006 Mar 7;5(3):294-302. | |
| Venkatesan RN, Hsu JJ, Lawrence NA, Preston BD, Loeb LA. Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta. J Biol Chem. 2006 Feb 17;281(7):4486-94. | |
| Fontes AM, Davis BM, Encell LP, Lingas K, Covas DT, Zago MA, Loeb LA, Pegg AE, Gerson SL. Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Mol Cancer Ther. 2006 Jan;5(1):121-8. | |
| Hansen AB, Griner NB, Anderson JP, Kujoth GC, Prolla TA, Loeb
LA, Glick E. Mitochondrial DNA integrity is not dependent on DNA
polymerase-beta activity. DNA Repair (Amst). 2006 Jan 5;5(1):71-9. |
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| Loeb LA, Wallace DC, Martin GM. The mitochondrial theory of aging and
its relationship to reactive oxygen species damage and somatic mtDNA
mutations. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18769-70. |
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| Loh E, Loeb LA. Mutability of DNA polymerase I: implications for the creation of mutant DNA polymerases. DNA Repair (Amst). 2005 Dec 8;4(12):1390-8 | |
| Beckman RA, Loeb LA. Negative clonal selection in tumor evolution. Genetics. 2005 Dec;171(4):2123-31. | |
| Beckman RA, Loeb LA. Genetic instability in cancer: theory and experiment. Semin Cancer Biol. 2005 Dec;15(6):423-35 |
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| Kamath-Loeb AS, Loeb LA, Masuda Y, Hanaoka F. The first US-Japan meeting on error-prone DNA synthesis, Maui, Hawaii, December 20-21, 2004. DNA Repair (Amst). 2005 Jun 8;4(6):740-7. | |
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Ozgenc A, Loeb LA. Current advances in unraveling the function of the Werner syndrome protein. Mutat Res. 2005 Jun 7 |
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Prehn RT, On the nature of cancer and why anticancer vaccines don't work. Cancer Cell International. 2005 Aug 1;5(1):25. |
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Bielas JH, Loeb LA. Quantification of random genomic mutations. Nat Methods. 2005 Apr;2(4):285-90. |
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Anderson JP, Angerer B, Loeb LA. Incorporation of reporter-labeled nucleotides by DNA polymerases. Biotechniques. 2005 Feb;38(2):257-64. |
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Bielas JH, Loeb LA. Mutator phenotype in cancer: timing and perspectives. Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):206-13 |
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Smith RA, Loeb LA, Preston BD. Lethal mutagenesis of HIV. Virus Res. 2005 Feb;107(2):215-28. Review. |
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Camps M, Loeb LA. Critical role of R-loops in processing replication blocks. Front Biosci. 2005 Jan 1;10:689-98. |
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Kamath-Loeb AS, Welcsh P, Waite M, Adman ET, Loeb LA. The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C. J Biol Chem. 2004 Dec 31;279(53):55499-505. |
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Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA. Environmental and chemical carcinogenesis. Semin Cancer Biol. 2004 Dec;14(6):473-86. Review. |
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Anderson JP, Daifuku R, Loeb LA. , Viral error catastrophe by mutagenic nucleosides. Annu Rev Microbiol. 2004;58:183-205. Review. |
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Khateb S, Weisman-Shomer P, Hershco I, Loeb LA, Fry M. Destabilization of tetraplex structures of the fragile X repeat sequence (CGG)n is mediated by homolog-conserved domains in three members of the hnRNP family. Nucleic Acids Res. 2004 Aug 9;32(14):4145-54. |
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Sneeden JL, Loeb LA. Mutations in the R2 subunit of ribonucleotide reductase that confer resistance to hydroxyurea. J Biol Chem. 2004 Sep 24;279(39):40723-8. |
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Guo, H. H, J. Choe and L.A. Loeb. Protein tolerance to random amino acid change. Proc Natl Acad Sci U S A., 2004. 101(25): p. 9205-10. |
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Martin, G.M., and L.A. Loeb. Ageing: mice and mitochondria. Nature., 2004. 429(6990): p. 357-9. |
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Blank, A., M.S. Bobola, B. Gold, S. Varadarajan, D.Kolstoe, E.H. Meade, P.S. Rabinovitch, L.A. Loeb, and J.R. Silber, The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function. DNA Repair (Amst), 2004. 3(6): p.629-38. |
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Camps, M. and L.A. Loeb. When pol I goes into high gear: processive DNA synthesis by pol I in the cell. Cell Cycle., 2004. 3(2): p. 116-8. |
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M. Camps and L.A. Loeb. Targeted mutagenesis in E. coli: a powerful tool for the generation of random mutant libraries. Discovery Medicine 2003. 3:18, 36-37 (invited review). |
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Guo, H. H, and L.A. Loeb. Tumbling down a different pathway to genetic instability. J Clin Invest., 2003. 112(12): p. 1793-5. |
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Shen J.C., Y. Lao, A. Kamath-Loeb, M.S. Wold, and L.A. Loeb. The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity. Mech Ageing Dev., 2003. 124(8-9): p. 921-30. |
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Shen, J.C., and L.A.
Loeb, Mutations in the
alpha8 loop of human APE1 alter binding and cleavage of DNA
containing an abasic site.
J Biol Chem.,
2003. 278(47): p. 46994-7001. |
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Camps M., J. Naukkarinen, B.P. Johnson, and L.A. Loeb. Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I. Proc Natl Acad Sci U S A., 2003. 100(17): p. 9727-32. |
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Davidson, J.F., R. Fox, D.D. Harris, S. Lyons-Abbott, and L.A. Loeb. Insertion of the T3 DNA polymerase thioredoxin binding domain enhances the processivity and fidelity of Taq DNA polymerase. Nucleic Acids Res., 2003. 31(16): p. 4702-9. |
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Venkatesan, R.N., and L.A. Loeb. Selection of novel eukaryotic DNA polymerases by mutagenesis and genetic complementation of yeast. Methods Mol Biol., 2003. 230: p. 19-26. |
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Camps, M., and L.A. Loeb. Use of Pol I-deficient E. coli for functional complementation of DNA polymerase. Methods Mol Biol., 2003. 230: p. 8-11. |
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Sneeden, J.L., and L.A. Loeb, Genetic complementation protocols. Methods Mol Biol., 2003. 230: p. 3-10. |
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Glick, E., J.S. Chau, K.L. Vigna, S.D. McCulloch, E.T. Adman, T.A.Kunkel, and L.A. Loeb. Amino acid substitutions at conserved tyrosine 52 alter fidelity and bypass efficiency of human DNA polymerase eta. J Biol Chem., 2003. 278(21): p. 19341-6. |
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Loeb, L.A., K.R. Loeb, and J.P. Anderson. Multiple mutations and cancer. Proc Natl Acad Sci U S A, 2003. 100(3): p. 776-81. |
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Glick, E., J.P. Anderson, and L.A. Loeb. In vitro production and screening of DNA polymerase eta mutants for catalytic diversity. Biotechniques, 2002. 33(5): p. 1136-42, 1144. |
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Kawate, H., D.M. Landis, and L.A. Loeb. Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine. J Biol Chem, 2002. 277(39): p. 36304-11. |
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Bergoglio, V., et al., Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis. Cancer Res, 2002. 62(12): p. 3511-4. |
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Davidson, J.F., H.H. Guo, and L.A. Loeb, Endogenous mutagenesis and cancer. Mutat Res, 2002. 509(1-2): p. 17-21. |
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Yang, Q., et al., The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem, 2002. 277(35): p. 31980-7. |
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Jackson, A.L. and L.A. Loeb, The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat Res, 2001. 477(1-2): p. 7-21. |
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Davis, B.M., et al., Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells. Proc Natl Acad Sci U S A, 2001. 98(9): p. 4950-4. |
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Shinkai, A., P.H. Patel, and L.A. Loeb, The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutable. J Biol Chem, 2001. 276(22): p. 18836-42. |
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Shinkai, A. and L.A. Loeb, In vivo mutagenesis by Escherichia coli DNA polymerase I. Ile(709) in motif A functions in base selection. J Biol Chem, 2001. 276(50): p. 46759-64. |
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Shen, J. and L.A. Loeb, Unwinding the molecular basis of the Werner syndrome. Mech Ageing Dev, 2001. 122(9): p. 921-44. |
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Glick, E., K.L. Vigna, and L.A. Loeb, Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions. Embo J, 2001. 20(24): p. 7303-12. |
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Patel, P.H., et al., Prokaryotic DNA polymerase I: evolution, structure, and "base flipping" mechanism for nucleotide selection. J Mol Biol, 2001. 308(5): p. 823-37. |
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Kamath-Loeb, A.S., et al., Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence. J Biol Chem, 2001. 276(19): p. 16439-46 |
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Patel, P.H., et al., A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity. J Biol Chem, 2001. 276(7): p. 5044-51. |
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Loeb, L.A., A mutator phenotype in cancer. Cancer Res, 2001. 61(8): p. 3230-9. |
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Landis, D.M., C.C. Heindel, and L.A. Loeb, Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase. Cancer Res, 2001. 61(2): p. 666-72. |
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Patel, P.H. and L.A. Loeb, Getting a grip on how DNA polymerases function. Nat Struct Biol, 2001. 8(8): p. 656-9. |
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Skandalis, A. and L.A. Loeb, Enzymatic properties of rat DNA polymerase beta mutants obtained by randomized mutagenesis. Nucleic Acids Res, 2001. 29(11): p. 2418-26. |
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Patel, P.H. and L.A. Loeb, DNA polymerase active site is highly mutable: evolutionary consequences. Proc Natl Acad Sci U S A, 2000. 97(10): p. 5095-100. |
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Patel, P.H. and L.A. Loeb, Multiple amino acid substitutions allow DNA polymerases to synthesize RNA. J Biol Chem, 2000. 275(51): p. 40266-72. |
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Kamath-Loeb, A.S., et al., Functional interaction between the Werner Syndrome protein and DNA polymerase delta. Proc Natl Acad Sci U S A, 2000. 97(9): p. 4603-8. |
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Uliel, L., et al., Human Ku antigen tightly binds and stabilizes a tetrahelical form of the Fragile X syndrome d(CGG)n expanded sequence. J Biol Chem, 2000. 275(42): p. 33134-41. |
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Suzuki, M., et al., Thermus aquaticus DNA polymerase I mutants with altered fidelity. Interacting mutations in the O-helix. J Biol Chem, 2000. 275(42): p. 32728-35. |
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Loeb, L.A. and J.I. Mullins, Lethal mutagenesis of HIV by mutagenic ribonucleoside analogs. AIDS Res Hum Retroviruses, 2000. 16(1): p. 1-3. |
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Shen, J.C. and L.A. Loeb, Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA. Nucleic Acids Res, 2000. 28(17): p. 3260-8. |
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Shen, J.C. and L.A. Loeb, The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases. Trends Genet, 2000. 16(5): p. 213-20. |
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Loeb, K.R. and L.A. Loeb, Significance of multiple mutations in cancer. Carcinogenesis, 2000. 21(3): p. 379-85. |
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Jackson, A.L. and L.A. Loeb, Microsatellite instability induced by hydrogen peroxide in Escherichia coli. Mutat Res, 2000. 447(2): p. 187-98. |
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Encell, L.P. and L.A. Loeb, Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase. Carcinogenesis, 2000. 21(7): p. 1397-402. |
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