Madison Clinic
For Providers For Patients Pharmacy Calendar Resources

[Print PDF 36kb]

Maraviroc

Other Names: Selzentry®

Manufacturer: Pfizer

What is it?

Maraviroc is a FDA approved antiretroviral medication, specifically, a CCR5 receptor blocker. It is used to treat HIV, a retrovirus. Retroviruses use the genetic material in the body’s cells to produce more virus, which can infect other cells.

How does it work?

Maraviroc is a new class of antiretroviral medication. It is designed to interfere with entry of HIV into the immune cells. Specifically, Maraviroc ties up the CCR5 receptor and blocks the virus from attaching to this receptor and gaining entry into the host’s immune cells.

How do I take it?

  • Maraviroc is available as 150mg and 300mg tablets.
  • The most common doses are 150mg and 300mg twice daily.
  • Maraviroc can be taken with or without food.

 

It is extremely important that you take maraviroc and your other antiretroviral medications exactly as directed. You should set up a system that will help you remember to take your medicines so that you do not miss any doses. If you miss a dose, take it as soon as possible and space the remaining doses out over the rest of the day. However, if you skip a dose, do not take two doses at once. Do not stop taking the medication for any reason at any time unless you are directed to do so by your provider. If you are unable to continue taking your medication due to side effects, you should contact your provider immediately.

Special Considerations

  • Maraviroc should be stored at room temperature (59° to 77° F or 5° to 25° C) and out of reach of children.
  • Maraviroc is sensitive to moisture so it should be stored in a dry place.

Interactions

Some drugs taken together may have interactions that cause illness or impair the effectiveness of the drugs. Since maraviroc is a new drug, studies are being done to determine what interactions there might be with other medications. Always check with your pharmacist or provider before taking any other medications, prescription or otherwise, to be sure it will not interact with maraviroc.

The following medications should not be given together with maraviroc:

  • St. John's Wort

Many other drugs may interact with maraviroc so you must tell your provider about all medications you are currently taking. This includes any medications that you may take on an ‘as needed’ basis, such as sleeping pills or pain medications and herbal or natural medicines.

The medications listed above may be known by other names. In addition, there are many other medications that may have a potential interaction with maraviroc. Please notify your provider of all medications you take, including other study medications and herbal medications.

Side Effects

Not everyone experiences side effects. When they do occur, they may be mild, moderate or severe. Some side effects cannot be felt by the patient but can be found through laboratory tests, so it is important to see your study clinician regularly for checkups so that side effects can be detected early and treated.

The most common side effects of maraviroc are cough, fever, upper respiratory tract infections, rash, musculoskeletal symptoms, abdominal pain and dizziness. Other side effects include diarrhea, fluid retention, sleep disorders, runny nose and urinary abnormalities.

Hepatotoxicity has been reported with maraviroc use. Evidence of a systemic allergic reaction (e.g., pruritic rash, eosinophilia or elevated IgE) prior to the development of hepatotoxicity may occur. Patients with signs or symptoms of hepatitis or allergic reaction following use of maraviroc should be evaluated immediately.

[top of page]