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2011
Hill, Z. B.; Perera, B. G. K.; Maly, D. J. “Bivalent inhibitors of the tyrosine kinases ABL and SRC: Molecular determinants of potency and selectivity.” Mol. BioSyst. 2011, 447-456. (DOI: 10.1039/c0mb00108b)
Krishnamurty, R.; Brock, A. M.; Maly, D. J. “5-AminoIndazoles as general affinity reagents for protein kinases” Bioorg. Med. Chem. Lett. 2011, 550-554. (DOI: 10.1016/j.bmcl.2010.10.069)
Hari, S. B.; Ranjitkar, P.; Maly, D. J. “Determination of the kinetics and thermodynamics of ligand binding to a specific inactive conformation in protein kinases” Methods Mol. Biol. 2011, (in press).
Ranjitkar, P.; Maly, D. J. “Affinity purification of protein kinases that adopt a specific inactive conformation” Methods Mol. Biol. 2011 (in press).
Goreshnik, I; Brock, A. M.; Maly, D. J. “Biochemical and Pharmacological Profiling of the Pro-Survival Protein Bcl-xL” Bioorg. Med. Chem. Lett. 2011 (in press).
2010
Goreshnik, I.; Maly, D. J. “A Small Molecule-Regulated Guanine Nucleotide Exchange Factor” J. Am. Chem. Soc. 2010,132, 938-940. (DOI: 10.1021/ja907886v). Highlighted in Faculty of 1000.
Krishnamurty, R.; Maly, D. J. “Biochemical Mechanisms of Resistance to Small-Molecule Protein Kinase Inhibitors” ACS Chem. Biol. 2010, 5, 121-138. (DOI: 10.1021/cb9002656).
Ranjitkar, P.; Brock, A. M.; Maly, D. J. “Affinity Probes that Target a Specific Inactive Conformation of Protein Kinases” Chem. Biol. 2010, 17, 195-206. (DOI: 10.1016/j.chembiol.2010.01.008)
Ojo, K. K.; Larson, E. T.; Keyloun, K. R.; Castaneda, L. J.; DeRocher, A. E.; Inampudi, K. K.; Kim, J. E.; Arakaki, T.; Murphy, R. C.; Zhang, L.; Napuli, A. J.; Maly, D. J.; Verlinde, C. L. M. J.; Buckner, F. S.; Parsons, M.; Hol, W. G. J.; Merritt, E. A.; Van Voorhis W. C. “Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.” Nat. Struct. Mol. Biol. 2010, 17, 602-607. (DOI: 10.1038/nsmb.1818).
Highlighted in Nat. Struct. Mol. Biol. 2010, 17, 541.
Murphy, R. C.; Ojo,K. K.; Larson, E. T.; Castellanos-Gonzalez, A.; Perera, B. G. K.; Keyloun, K. R.; Kim, J. E.; Bhandari, J. G.; Muller, N. R.; Verlinde, C. L. M. J.; White, C. A.; Merritt, E. A.; ^Van Voorhis, W. C.; ^Maly, D. J. “Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.” ACS Med. Chem. Lett. 2010,1,331-335. (DOI: 10.1021/ml100096t)
Gregersen, K. A. D.; Hill, Z. B.; Gadd, J. C.; Fujimoto, B.; Maly, D. J.; Chiu D. T. “Intracellular Delivery of Bioactive Molecules Using Light-Addressable Nanocapsules” ACS Nano 2010, 7603-7611. (DOI: 10.1021/nn102345f)
2009
Seeliger, M. A.; Ranjitkar, P.; Kasap. C.; Shan, Y.; Shaw, D. E.; Shah, N. E.; Kuriyan, J.; Maly, D. J. “Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations” Cancer Res. 2009, 69, 2384-2392. (DOI: 10.1158/0008-5472.CAN-08-3953)
Highlighted in: Nature Chemical Biology 2009 Vol. 5, 204; Faculty of 1000.
Blacken, G. R.; Volný, M.; Diener, M.; Jackson, K. E.; Ranjitkar, P.; Maly, D. J.; Tureček, F. “Reactive Landing of Gas-Phase Ions as a Tool for the Fabrication of Metal Oxide Surfaces for In Situ Phosphopeptide Enrichment” J. Am. Soc. Mass Spectrom. 2009, 915-926. (DOI: 10.1016/j.jasms.2009.01.006).
Hill, Z. B.; Perera, B. G. K.; Maly, D. J.“A Chemical Genetic Method for Generating Bivalent Inhibitors of Protein Kinases.” J. Am. Chem. Soc. 2009, 131, 6686-6688. (DOI: 10.1021/ja900871y)
Highlighted in: ACS Chem. Biol. 2009, 4, p. 492; ChemBioChem 2009, 10, p. 2445; Nature SciBX 2009, Vol. 2(#18), 19; Faculty of 1000. This paper was selected by the ACS Chemical Biology Editors as one of the best Chemical Biology articles of 2009 (ACS Chem. Biol. 2010, 5, 10).
2008
Perera, G.; Maly, D. J. ”Design, Synthesis and Characterization of ”Clickable” 4-Anilinoquinazoline Kinase Inhibitors” Mol. BioSyst. 2008, 4, 542. (DOI: 10.1039/b720014e)
Statsuk, A. V.; Maly, D. J.; Seeliger, M. A.; Fabian, M. A.; Biggs, W. H.; Lockhart, D. J.; Zarrinkar, P. P.; Kuriyan, J.; Shokat, K. M. “Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes.” J. Am. Chem. Soc. 2008, 130, 17568. (DOI: 10.1021/ja807066f)
2007
Maly, D.J. “Exploring the Intermembrane Space.” ACS Chem. Biol. 2007, 2, 213.
Krishnamurty, R.; Maly, D. J. “Chemical Genomic and Proteomic Methods for Determining Kinase Inhibitor Selectivity” Comb. Chem. High Throughput Screening 2007, 10, 652.
Before 2006
Gosalia, D. N.; Salisbury, C. M.; Maly D. J.; Ellman, J. A.; Diamond, S. L. “Profiling Serine Protease Substrate Specificity with Solution Phase Fluorogenic Peptide Microarrays” Proteomics 2005, 5, 1292.
Maly, D. J.; Allen, J. A.; Shokat, K. M. “A Mechanism-Based Cross-Linker for the Identification of Kinase-Substrate Pairs” J. Am. Chem. Soc. 2004, 126, 9160.
Maly, D. J.; Huang, L.; Ellman, J. A. “Combinatorial Strategies for Targeting Protein Families. Application to the Proteases” ChemBioChem 2002, 3, 16.
Kehoe, J. W.; Maly, D. J.; Verdugo, D. E.; Armstrong, J. I.; Cook, B. N.; Moore, K. L.; Ellman, J. A.; Bertozzi, C. R. “Tyrosyl Protein Sulfotransferase Inhibitors Generated by Combinatorial Target-Guided Ligand Assembly” Bioorg. Med. Chem. Lett. 2002, 12, 329.
Maly, D. J.; Leonetti, F.; Backes, B. J.; Dauber, D. S.; Harris, J. L.; Craik, C. S.; Ellman, J. A. “Expedient Solid-Phase Synthesis of Fluorogenic Protease Substrates Using the 7-Amino-4-Carbamoylmethylcoumarin (ACC) Fluorophore” J. Org. Chem. 2002, 67, 910.
Dauber, D. S.; Ziermann, R.; Parkin, N.; Maly, D. J.; Mahrus, S.; Harris, J. L.; Ellman, J. A.; Petropoulos, C.; Craik, C. S. “Altered Substrate Specificity of Drug-Resistant HIV-1 Protease” J. Virol. 2002, 76, 1359.
Salisbury, C. M.; Maly, D. J.; Ellman, J. A. “Peptide Microarrays for the Determination of Protease Substrate Specificity” J. Am. Chem. Soc. 2002, 124, 14868.
Maly, D. J.; Choong, C.; Ellman, J. A. “Combinatorial Target-Guided Ligand Assembly: Identification of Potent Subtype-Selective c-Src Inhibitors” Proc. Natl. Acad. Sci. USA 2000, 97, 2419.
Mann, D. A.; Kanai, M.; Maly, D. J.; Kiessling, L. L. “Probing Low Affinity and Multivalent Interactions with Surface Plasmon Resonance: Ligands for Concanavalin A” J. Am. Chem. Soc. 1998, 120, 10575.
