Publications
(^ = co-corresponding author)
Brigham, J. L.; Perera, B. G. K.; Maly, D. J. "A hexylchloride-based catch-and-release system for chemical proteomic applications" ACS Chem. Biol. 2013, (in press). (DOI: 10.1021/cb300623a)
Andrews, S. S.; Hill, Z. B.; Perera, B. G. K.; Maly, D. J. "Label Transfer Reagents to Probe p38 MAPK Binding Partners" ChemBioChem 2013, 14, 209-216. (DOI: 10.1002/cbic.201200673)
Ranjitkar, P.; Perera, B. G. K.; Swaney, D.; Hari, S. B.; Larson, E. T.; Krishnamurty, R.; Merritt, E. A.; Villén, J.; Maly, D. J. "Affinity-Based Probes Based on Type II Kinase Inhibitors" J. Am. Chem. Soc. 2012, 134, 19017-19025. (DOI: 10.1021/ja306035v)
Wang, L.; Perera, B. G. K.; Hari, S. B.; Bhhatarai, B.; Backes, B. J.; Seeliger, M. A.; Schürer, S. C.; Oakes, S. A.; ^Papa, F. A.; ^Maly, D. J. "Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors." Nat. Chem. Biol. 2012, 8, 982-989. (DOI: 10.1038/nchembio.1094)
Krishnamurty, R.; Brigham, J. L.; Leonard, S. E.; Ranjitkar, P.; Dale, E. J.; Larson, E. T.; Merritt, E. A.; Maly, D. J. "Active site profiling reveals coupling between domains in SRC-family kinases" Nat. Chem. Biol. 2013, 9, 43-50. (DOI: 10.1038/NChemBio.1118)
Zhang, Z.; Ojo, K. K.; Johnson, S. M.; Larson, E. T.; He, P.; Geiger, J. A.; Castellanos-Gonzalez, A.; White, C. A.; Parsons, M.; Merritt, E. A.; Maly, D. J.; Verlinde, C. L. M. J.; Van Voorhis, W. C.; Fan, E. "Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1" Bioorg. Med. Chem. Lett. 2012, 5264-5267.(DOI: 10.1016/j.bmcl.2012.06.050)
Larson, E. T.; Ojo, K. K.; Murphy, R. C.; Johnson, S. M.; Zhang, Z.; Kim, J. E.; Leibly, D. J.; Fox, A. M. W.; Reid, M. C.; Dale, E. J.; Perera, B. G. K.; Kim, J.; Hewitt, S. N.; Hol, W. G. J.; Verlinde, C. M. J.; Fan, E.; ^Van Voorhis, W. C.; ^Maly, D. J.; ^Merritt, E. A. "Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1." J. Med. Chem. 2012, 2803-2810. (DOI: 10.1021/jm201725v)
Johnson, S. M.; Murphy, R. C.; Geiger, J. A.; DeRocher, A. E.; Zhang, Z.; Ojo, K. K.; Larson, E. T.; Perera, B. G. K.; Dale, E. J.; He, P.; Reid, M. C.; Fox, A. M. W.; Mueller, N. R.; Merritt, E. A.; Fan, E.; Parsons, M.; ^Van Voorhis, W. C.; ^Maly, D. J. "Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity." J. Med. Chem. 2012, 55, 2416-2426. (DOI: 10.1021/jm201713h)
Ojo, K. K.; Pfander, C.; Mueller, N. R.; Burstroem, C.; Larson, E. T.; Bryan, C. M.; Fox, A. M. W.; Reid, M. C.; Johnson, S. M.; Murphy, R. C.; Kennedy, M.; Mann, H.; Leibly, D. J.; Hewitt, S. N.; Verlinde, C. M. J.; Kappe, S.; Merritt, E. A.; ^Maly, D. J.; ^Billker, O.; ^Van Voorhis, W. C. "Transmission blocking compound BKI-1 prevents malaria infection of mosquitoes." J. Clin. Invest. 2012, 2301-2305. (DOI: 10.1172/JCI61822)
Hill, Z. B.; Perera, B. G. K.; Andrews, S.; Maly, D. J. "Targeting Diverse Signaling Interaction Sites Allows the Rapid Generation of Bivalent Kinase Inhibitors." ACS Chem. Biol. 2012, 7, 487-495. (DOI: 10.1021/cb200387g)
Hari, S. B.; Ranjitkar, P.; Maly, D. J. "Determination of the kinetics and thermodynamics of ligand binding to a specific inactive conformation in protein kinases." Methods Mol. Biol. 2012, 928, 153-159.(DOI: 10.1007/978-1-62703-008-3_12)
Ranjitkar, P.; Maly, D. J. "Affinity purification of protein kinases that adopt a specific inactive conformation." Methods Mol. Biol. 2012, 928, 143-151.(DOI: 10.1007/978-1-62703-008-3_11)
Goreshnik, I; Brock, A. M.; Maly, D. J. "Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL." Bioorg. Med. Chem. Lett. 2011, 21, 4951-4955.(DOI: 10.1016/j.bmcl.2011.06.134)
Hill, Z. B.; Perera, B. G. K.; Maly, D. J. "Bivalent inhibitors of the tyrosine kinases ABL and SRC: Molecular determinants of potency and selectivity." Mol. BioSyst. 2011, 7, 447-456. (DOI: 10.1039/c0mb00108b)
Krishnamurty, R.; Brock, A. M.; Maly, D. J. "5-AminoIndazoles as general affinity reagents for protein kinases." Bioorg. Med. Chem. Lett. 2011, 21, 550-554. (DOI: 10.1016/j.bmcl.2010.10.069)
Murphy, R. C.; Ojo, K. K.; Larson, E. T.; Castellanos-Gonzalez, A.; Perera, B. G. K.; Keyloun, K. R.; Kim, J. E.; Bhandari, J. G.; Muller, N. R.; Verlinde, C. L. M. J.; White, C. A.; Merritt, E. A.; ^Van Voorhis, W. C.; ^Maly, D. J. "Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii." ACS Med. Chem. Lett. 2010, 1, 331-335. (DOI: 10.1021/ml100096t)
Ojo, K. K.; Larson, E. T.; Keyloun, K. R.; Castaneda, L. J.; DeRocher, A. E.; Inampudi, K. K.; Kim, J. E.; Arakaki, T.; Murphy, R. C.; Zhang, L.; Napuli, A. J.; Maly, D. J.; Verlinde, C. L. M. J.; Buckner, F. S.; Parsons, M.; Hol, W. G. J.; Merritt, E. A.; Van Voorhis W. C. "Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors." Nat. Struct. Mol. Biol. 2010, 17, 602-607. (DOI: 10.1038/nsmb.1818)
Gregersen, K. A. D.; Hill, Z. B.; Gadd, J. C.; Fujimoto, B.; Maly, D. J.; Chiu, D. T. "Intracellular Delivery of Bioactive Molecules Using Light-Addressable Nanocapsules." ACS Nano 2010, 4, 7603-7611. (DOI: 10.1021/nn102345f)
Goreshnik, I.; Maly, D. J. "A Small Molecule-Regulated Guanine Nucleotide Exchange Factor" J. Am. Chem. Soc. 2010, 132, 938. (DOI: 10.1021/ja907886v)
Krishnamurty, R.; Maly, D. J. "Biochemical Mechanisms of Resistance to Small-Molecule Protein Kinase Inhibitors" ACS Chem. Biol. 2010, 5, 121. (DOI: 10.1021/cb9002656)
Ranjitkar, P.; Brock, A. M.; Maly, D. J. "Affinity Probes that Target a Specific Inactive Conformation of Protein Kinases" Chem. Biol. 2010, 17, 195. (DOI: 10.1016/j.chembiol.2010.01.008)
Blacken, G. R.; Volný, M.; Diener, M.; Jackson, K. E.; Ranjitkar, P.; Maly, D. J.; Tureček, F. "Reactive Landing of Gas-Phase Ions as a Tool for the Fabrication of Metal Oxide Surfaces for In Situ Phosphopeptide Enrichment" J. Am. Soc. Mass Spectrom. 2009, 915. (DOI: 10.1016/j.jasms.2009.01.006)
Hill, Z. B.; Perera, B. G. K.; Maly, D. J. "A Chemical Genetic Method for Generating Bivalent Inhibitors of Protein Kinases." J. Am. Chem. Soc. 2009, 131, 6686. (DOI: 10.1021/ja900871y)
Seeliger, M. A.; Ranjitkar, P.; Kasap. C.; Shan, Y.; Shaw, D. E.; Shah, N. E.; Kuriyan, J.; Maly, D. J. "Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations" Cancer Res. 2009, 69, 2384. (DOI: 10.1158/0008-5472.CAN-08-3953)
Perera, G.; Maly, D. J. "Design, Synthesis and Characterization of "Clickable" 4-Anilinoquinazoline Kinase Inhibitors" Mol. BioSyst. 2008, 4, 542. (DOI: 10.1039/b720014e)
Statsuk, A. V.; Maly, D. J.; Seeliger, M. A.; Fabian, M. A.; Biggs, W. H.; Lockhart, D. J.; Zarrinkar, P. P.; Kuriyan, J.; Shokat, K. M. "Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes." J. Am. Chem. Soc. 2008, 130, 17568. (DOI: 10.1021/ja807066f)
Maly, D.J. "Exploring the Intermembrane Space." ACS Chem. Biol. 2007, 2, 213.
Krishnamurty, R.; Maly, D. J. "Chemical Genomic and Proteomic Methods for Determining Kinase Inhibitor Selectivity" Comb. Chem. High Throughput Screening 2007, 10, 652.
Gosalia, D. N.; Salisbury, C. M.; Maly D. J.; Ellman, J. A.; Diamond, S. L. "Profiling Serine Protease Substrate Specificity with Solution Phase Fluorogenic Peptide Microarrays" Proteomics 2005, 5, 1292.
Maly, D. J.; Allen, J. A.; Shokat, K. M. "A Mechanism-Based Cross-Linker for the Identification of Kinase-Substrate Pairs" J. Am. Chem. Soc. 2004, 126, 9160.
Maly, D. J.; Huang, L.; Ellman, J. A. "Combinatorial Strategies for Targeting Protein Families. Application to the Proteases" ChemBioChem 2002, 3, 16.
Kehoe, J. W.; Maly, D. J.; Verdugo, D. E.; Armstrong, J. I.; Cook, B. N.; Moore, K. L.; Ellman, J. A.; Bertozzi, C. R. "Tyrosyl Protein Sulfotransferase Inhibitors Generated by Combinatorial Target-Guided Ligand Assembly" Bioorg. Med. Chem. Lett. 2002, 12, 329.
Maly, D. J.; Leonetti, F.; Backes, B. J.; Dauber, D. S.; Harris, J. L.; Craik, C. S.; Ellman, J. A. "Expedient Solid-Phase Synthesis of Fluorogenic Protease Substrates Using the 7-Amino-4-Carbamoylmethylcoumarin (ACC) Fluorophore" J. Org. Chem. 2002, 67, 910.
Dauber, D. S.; Ziermann, R.; Parkin, N.; Maly, D. J.; Mahrus, S.; Harris, J. L.; Ellman, J. A.; Petropoulos, C.; Craik, C. S. "Altered Substrate Specificity of Drug-Resistant HIV-1 Protease" J. Virol. 2002, 76, 1359.
Salisbury, C. M.; Maly, D. J.; Ellman, J. A. "Peptide Microarrays for the Determination of Protease Substrate Specificity" J. Am. Chem. Soc. 2002, 124, 14868.
Maly, D. J.; Choong, I. C.; Ellman, J. A. "Combinatorial Target-Guided Ligand Assembly: Identification of Potent Subtype-Selective c-Src Inhibitors" Proc. Natl. Acad. Sci. USA 2000, 97, 2419.
Mann, D. A.; Kanai, M.; Maly, D. J.; Kiessling, L. L. "Probing Low Affinity and Multivalent Interactions with Surface Plasmon Resonance: Ligands for Concanavalin A" J. Am. Chem. Soc. 1998, 120, 10575.