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Publications 2011 Hill, Z. B.; Perera, B. G. K.; Maly, D. J. “Bivalent inhibitors of the tyrosine kinases ABL and SRC: Molecular determinants of potency and selectivity.” Mol. BioSyst. 2011, 447-456. (DOI: 10.1039/c0mb00108b) Krishnamurty, R.; Brock, A. M.; Maly, D. J. “5-AminoIndazoles as general affinity reagents for protein kinases” Bioorg. Med. Chem. Lett. 2011, 550-554. (DOI: 10.1016/j.bmcl.2010.10.069) Hari, S. B.; Ranjitkar, P.; Maly, D. J. “Determination of the kinetics and thermodynamics of ligand binding to a specific inactive conformation in protein kinases” Methods Mol. Biol. 2011, (in press). Ranjitkar, P.; Maly, D. J. “Affinity purification of protein kinases that adopt a specific inactive conformation” Methods Mol. Biol. 2011 (in press). Goreshnik, I; Brock, A. M.; Maly, D. J. “Biochemical and Pharmacological Profiling of the Pro-Survival Protein Bcl-xL” Bioorg. Med. Chem. Lett. 2011 (in press). 2010 Goreshnik, I.; Maly, D. J. “A Small Molecule-Regulated Guanine Nucleotide Exchange Factor” J. Am. Chem. Soc. 2010,132, 938-940. (DOI: 10.1021/ja907886v). Highlighted in Faculty of 1000. Krishnamurty, R.; Maly, D. J. “Biochemical Mechanisms of Resistance to Small-Molecule Protein Kinase Inhibitors” ACS Chem. Biol. 2010, 5, 121-138. (DOI: 10.1021/cb9002656). Ranjitkar, P.; Brock, A. M.; Maly, D. J. “Affinity Probes that Target a Specific Inactive Conformation of Protein Kinases” Chem. Biol. 2010, 17, 195-206. (DOI: 10.1016/j.chembiol.2010.01.008) Ojo, K. K.; Larson, E. T.; Keyloun, K. R.; Castaneda, L. J.; DeRocher, A. E.; Inampudi, K. K.; Kim, J. E.; Arakaki, T.; Murphy, R. C.; Zhang, L.; Napuli, A. J.; Maly, D. J.; Verlinde, C. L. M. J.; Buckner, F. S.; Parsons, M.; Hol, W. G. J.; Merritt, E. A.; Van Voorhis W. C. “Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.” Nat. Struct. Mol. Biol. 2010, 17, 602-607. (DOI: 10.1038/nsmb.1818). Murphy, R. C.; Ojo,K. K.; Larson, E. T.; Castellanos-Gonzalez, A.; Perera, B. G. K.; Keyloun, K. R.; Kim, J. E.; Bhandari, J. G.; Muller, N. R.; Verlinde, C. L. M. J.; White, C. A.; Merritt, E. A.; ^Van Voorhis, W. C.; ^Maly, D. J. “Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.” ACS Med. Chem. Lett. 2010,1,331-335. (DOI: 10.1021/ml100096t) Gregersen, K. A. D.; Hill, Z. B.; Gadd, J. C.; Fujimoto, B.; Maly, D. J.; Chiu D. T. “Intracellular Delivery of Bioactive Molecules Using Light-Addressable Nanocapsules” ACS Nano 2010, 7603-7611. (DOI: 10.1021/nn102345f) 2009 Seeliger, M. A.; Ranjitkar, P.; Kasap. C.; Shan, Y.; Shaw, D. E.; Shah, N. E.; Kuriyan, J.; Maly, D. J. “Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations” Cancer Res. 2009, 69, 2384-2392. (DOI: 10.1158/0008-5472.CAN-08-3953)
Blacken, G. R.; Volný, M.; Diener, M.; Jackson, K. E.; Ranjitkar, P.; Maly, D. J.; Tureček, F. “Reactive Landing of Gas-Phase Ions as a Tool for the Fabrication of Metal Oxide Surfaces for In Situ Phosphopeptide Enrichment” J. Am. Soc. Mass Spectrom. 2009, 915-926. (DOI: 10.1016/j.jasms.2009.01.006). Hill, Z. B.; Perera, B. G. K.; Maly, D. J.“A Chemical Genetic Method for Generating Bivalent Inhibitors of Protein Kinases.” J. Am. Chem. Soc. 2009, 131, 6686-6688. (DOI: 10.1021/ja900871y)
2008 Perera, G.; Maly, D. J. ”Design, Synthesis and Characterization of ”Clickable” 4-Anilinoquinazoline Kinase Inhibitors” Mol. BioSyst. 2008, 4, 542. (DOI: 10.1039/b720014e) Statsuk, A. V.; Maly, D. J.; Seeliger, M. A.; Fabian, M. A.; Biggs, W. H.; Lockhart, D. J.; Zarrinkar, P. P.; Kuriyan, J.; Shokat, K. M. “Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes.” J. Am. Chem. Soc. 2008, 130, 17568. (DOI: 10.1021/ja807066f) 2007 Maly, D.J. “Exploring the Intermembrane Space.” ACS Chem. Biol. 2007, 2, 213. Krishnamurty, R.; Maly, D. J. “Chemical Genomic and Proteomic Methods for Determining Kinase Inhibitor Selectivity” Comb. Chem. High Throughput Screening 2007, 10, 652. Before 2006 Gosalia, D. N.; Salisbury, C. M.; Maly D. J.; Ellman, J. A.; Diamond, S. L. “Profiling Serine Protease Substrate Specificity with Solution Phase Fluorogenic Peptide Microarrays” Proteomics 2005, 5, 1292. Maly, D. J.; Allen, J. A.; Shokat, K. M. “A Mechanism-Based Cross-Linker for the Identification of Kinase-Substrate Pairs” J. Am. Chem. Soc. 2004, 126, 9160. Maly, D. J.; Huang, L.; Ellman, J. A. “Combinatorial Strategies for Targeting Protein Families. Application to the Proteases” ChemBioChem 2002, 3, 16. Kehoe, J. W.; Maly, D. J.; Verdugo, D. E.; Armstrong, J. I.; Cook, B. N.; Moore, K. L.; Ellman, J. A.; Bertozzi, C. R. “Tyrosyl Protein Sulfotransferase Inhibitors Generated by Combinatorial Target-Guided Ligand Assembly” Bioorg. Med. Chem. Lett. 2002, 12, 329. Maly, D. J.; Leonetti, F.; Backes, B. J.; Dauber, D. S.; Harris, J. L.; Craik, C. S.; Ellman, J. A. “Expedient Solid-Phase Synthesis of Fluorogenic Protease Substrates Using the 7-Amino-4-Carbamoylmethylcoumarin (ACC) Fluorophore” J. Org. Chem. 2002, 67, 910. Dauber, D. S.; Ziermann, R.; Parkin, N.; Maly, D. J.; Mahrus, S.; Harris, J. L.; Ellman, J. A.; Petropoulos, C.; Craik, C. S. “Altered Substrate Specificity of Drug-Resistant HIV-1 Protease” J. Virol. 2002, 76, 1359. Salisbury, C. M.; Maly, D. J.; Ellman, J. A. “Peptide Microarrays for the Determination of Protease Substrate Specificity” J. Am. Chem. Soc. 2002, 124, 14868. Maly, D. J.; Choong, C.; Ellman, J. A. “Combinatorial Target-Guided Ligand Assembly: Identification of Potent Subtype-Selective c-Src Inhibitors” Proc. Natl. Acad. Sci. USA 2000, 97, 2419. Mann, D. A.; Kanai, M.; Maly, D. J.; Kiessling, L. L. “Probing Low Affinity and Multivalent Interactions with Surface Plasmon Resonance: Ligands for Concanavalin A” J. Am. Chem. Soc. 1998, 120, 10575.
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