The UW ADRC funds one-year pilot projects that use its resources to advance the understanding, diagnosis, and/or treatment of Alzheimer’s disease. The UW ADRC will fund at least two awards for junior researchers of up $30,000 each, and one award of up to $75,000, which is also open to established researchers new to the ADRC.
Junior Investigators and projects:
Douglas Barthold, PhD, Research Assistant Professor, Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, Department of Pharmacy, UW.
Project: Alzheimer’s disease related neuropathology among patients with medication treated type 2 diabetes in a community-based autopsy cohort
Erik S. Carlson, MD, PhD, Assistant Professor, Psychiatry and Behavioral Sciences, UW.
Project: Compensatory Cerebellar Circuits in Mild Cognitive Impairment and Alzheimer Disease.
Judit Marsillach, PhD, Acting Assistant Professor of Medicine, Division of Medical Genetics, UW.
Project: Paraoxonase-1 as an early biomarker of Alzheimer’s Disease
Previously Funded Pilot Projects
Michelle Erickson, PhD, Research Assistant Professor, UW Gerontology and Geriatric Medicine / Research Biologist, VA Puget Sound Healthcare System.
Project: Serum amyloid A as a liver-derived mediator of Alzheimer’s disease.
Robert Freishtat, MD, MPH, Chief of Emergency Medicine, Children’s National Health System/ Professor of Pediatrics, Emergency Medicine, and Integrative Systems Biology, George Washington University School of Medicine and Health Sciences.
Project: Neurodegeneration by adipocyte-derived exosomes in dementia.
Hesamoddin Jahanian, PhD, Assistant Professor, Integrated Brain Imaging Center (IBIC), Department of Radiology, UW.
Project: Development of Ultrafast Resting-State fMRI as a Biomarker for Alzheimer’s Disease.
Richard S. Morrison, PhD, Staatz Professor of Neurological Surgery, UW; Director, Center for Neuroproteomics.
Project: Epigenetic role for histone deacetylase 2 in Alzheimer’s disease pathogenesis.
Paul Valdmanis, PhD, Assistant Professor, Division of Medical Genetics, UW.
Project: Contribution of human-specific repeat expansions to Alzheimer’s Disease.
Martin Darvas, PhD Multiplex assay for the quantification of antigens in paraffin-embedded tissue.
Meghan Jernigan, MPH Alzheimer’s disease research pilot for American Indians and Alaska natives.
Caitlin Latimer, MD, PhD Human and Non-Human Primate Synaptic Damage.
Erica Melief, PhD Dopaminergic influence on amyloid beta.
Jessica Young, PhD Probing the role of endocytic network in sporadic AD risk using human induced pluripotent stem cells.
Andrew Hoofnagle, MD, PhD Quantification of A-beta and Tau in CSF by LC-MS/MS.
Olena Korvatska, PhD Role of the R41H TREM2 variant in the pathogenesis of late onset AD.
Brian Kraemer, MD, PhD Preclinical Study of D2 Antagonists for Neuroprotection Against Pathological Tau.
Tara Madhyastha, PhD Neuroimaging Biomakers of Cognitive Resilience Among APOE-4 Carriers.
Desiree Marshall, MD Novel Data and Tissue Resource to Study CTE and AD Neuropathology.
Lonnie Nelson, PhD Strong Heart Stroke Study for Urban Indians and Alaska Natives Americans.
Min Shi, PhD Pilot study of potential Alzheimer’s disease biomarkers in human saliva.
Jeannine Skinner, PhD Health Education, Aerobic and Resistance Training (HEART) in Prediabetic African Americans to compare the effects of exercise and health education on the thinking abilities, insulin sensitivity, and levels of Alzheimer's biomarkers in a group of African Americans with prediabetes.
Jessica (Foraker) Tulloch, PhD Epigenetics of APOE in Alzheimer’s Disease Neurons.
Adrienne Wang, PhD The effects of natural variation on Alzheimer's pathology in Drosophila.
Seed Grant Projects
Alexander Mendenhall, PhD Cell autonomous and cell non autonomous pathologies caused by expression of A-beta, Tau and alpha-synuclein in C. elegans.
C. Dirk Keene, MD, PhD Neuropathology Core resource for induced pluripotent stem cells.