The UW ADRC offers one-year development projects that use its resources to advance the understanding, diagnosis, and/or treatment of Alzheimer’s disease. In the 2022- 2023 period, the UW ADRC aims to fund 3-4 projects of up to $50,000 each. At least two awards will be reserved for junior applicants (Postdoctoral fellows with appropriate senior collaborators or junior faculty up to the rank of Assistant Professor). Funds would be awarded for a one-year project period, 5/1/2022 through 4/30/2023. The proposed project must be feasible within this time frame .
The Development Projects program replaces and extends the former Pilot Award program, and is closely linked to our new Research Education Component. The currently funded ADRC Development Projects are listed here:
2021 - 2022
Kimberly Alonge, PhD. Acting Instructor, UW Medicine
Project: Brain glycan sulfation recoding in Alzheimer's disease
Katherine Prater, PhD. Postdoctoral Research Fellow (Jayadev Lab), Department of Neurology, UW Medicine
Project: Understanding microglia responses in resilience, cognitive decline, and neuropathological proteopathy
Astrid Suchy-Dicey, PhD. Assistant Professor, Elson S. Floyd Collecge of Medicine, Washington State University
Project: Plasma phosphorylated tau protein and Alzheimer's disease in American Indians: The Strong Heart Study
Yuliang Wang, PhD. Research Assistant Professor, Paul Allen School of Computer Science and Engineering/Institute for Stem Cell & Regenerative Medicine, University of Washington
Project: Using metabolic network modeling to improve the maturity of iPSC-derived microglia for Alzheimer's disease
Meredith Course, PhD Postdoctoral Fellow, Division of Medical Genetics, UW Medicine.
Project: Novel Transcripts of PSEN1 and PSEN2 in Familial and Sporadic Alzheimer Disease
Deidre Jansson, MSc, PhD Senior Postdoctoral Fellow, Department of Psychiatry and Behavioral Sciences, UW School of Medicine
Project: Defining the cellular and transcriptomics architecture of the choroid plexus in Alzheimer's disease: a pilot study
Elizabeth Rhea, PhD Research Biologist, VA Puget Sound Health Care System/ Research Assistant Professor, Division of Gerontology, UW
Project: Soluble insulin receptor levels in Alzheimer's disease
Past Pilot Projects
The Development Projects program replaces and extends the former Pilot Award program. The previously funded ADRC Pilot Projects are listed here:
Junior Investigators and projects:
Douglas Barthold, PhD Research Assistant Professor, Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, Department of Pharmacy, UW.
Project: Alzheimer’s disease related neuropathology among patients with medication treated type 2 diabetes in a community-based autopsy cohort
Erik S. Carlson, MD, PhD Assistant Professor, Psychiatry and Behavioral Sciences, UW.
Project: Compensatory Cerebellar Circuits in Mild Cognitive Impairment and Alzheimer Disease.
Judit Marsillach, PhD Acting Assistant Professor of Medicine, Division of Medical Genetics, UW.
Project: Paraoxonase-1 as an early biomarker of Alzheimer’s Disease
Michelle Erickson, PhD Research Assistant Professor, UW Gerontology and Geriatric Medicine / Research Biologist, VA Puget Sound Healthcare System.
Project: Serum amyloid A as a liver-derived mediator of Alzheimer’s disease.
Robert Freishtat, MD, MPH Chief of Emergency Medicine, Children’s National Health System/ Professor of Pediatrics, Emergency Medicine, and Integrative Systems Biology, George Washington University School of Medicine and Health Sciences.
Project: Neurodegeneration by adipocyte-derived exosomes in dementia.
Hesamoddin Jahanian, PhD Assistant Professor, Integrated Brain Imaging Center (IBIC), Department of Radiology, UW.
Project: Development of Ultrafast Resting-State fMRI as a Biomarker for Alzheimer’s Disease.
Richard S. Morrison, PhD Staatz Professor of Neurological Surgery, UW; Director, Center for Neuroproteomics.
Project: Epigenetic role for histone deacetylase 2 in Alzheimer’s disease pathogenesis.
Paul Valdmanis, PhD Assistant Professor, Division of Medical Genetics, UW.
Project: Contribution of human-specific repeat expansions to Alzheimer’s Disease.
Martin Darvas, PhD Multiplex assay for the quantification of antigens in paraffin-embedded tissue.
Meghan Jernigan, MPH Alzheimer’s disease research pilot for American Indians and Alaska natives.
Caitlin Latimer, MD, PhD Human and Non-Human Primate Synaptic Damage.
Erica Melief, PhD Dopaminergic influence on amyloid beta.
Jessica Young, PhD Probing the role of endocytic network in sporadic AD risk using human induced pluripotent stem cells.
Andrew Hoofnagle, MD, PhD Quantification of A-beta and Tau in CSF by LC-MS/MS.
Olena Korvatska, PhD Role of the R41H TREM2 variant in the pathogenesis of late onset AD.
Brian Kraemer, MD, PhD Preclinical Study of D2 Antagonists for Neuroprotection Against Pathological Tau.
Tara Madhyastha, PhD Neuroimaging Biomakers of Cognitive Resilience Among APOE-4 Carriers.
Desiree Marshall, MD Novel Data and Tissue Resource to Study CTE and AD Neuropathology.
Lonnie Nelson, PhD Strong Heart Stroke Study for Urban Indians and Alaska Natives Americans.
Min Shi, PhD Pilot study of potential Alzheimer’s disease biomarkers in human saliva.
Jeannine Skinner, PhD Health Education, Aerobic and Resistance Training (HEART) in Prediabetic African Americans to compare the effects of exercise and health education on the thinking abilities, insulin sensitivity, and levels of Alzheimer's biomarkers in a group of African Americans with prediabetes.
Jessica (Foraker) Tulloch, PhD Epigenetics of APOE in Alzheimer’s Disease Neurons.
Adrienne Wang, PhD The effects of natural variation on Alzheimer's pathology in Drosophila.
Seed Grant Projects
Alexander Mendenhall, PhD Cell autonomous and cell non autonomous pathologies caused by expression of A-beta, Tau and alpha-synuclein in C. elegans.
C. Dirk Keene, MD, PhD Neuropathology Core resource for induced pluripotent stem cells.