Research Highlights & Calendar

 

The UW Memory and Brain Wellness Center research activities comprise:

Current research projects within the UW Alzheimer's Research Center (ADRC) that focus on a precision medicine approach to Alzheimer's disease:

  • Project 1 Title: Mechanisms Linking Normative Aging with Alzheimer’s Disease. Project leader: Dr. Matt Kaeberlein, Professor, Department of Pathology, University of Washington Learn more
  • Project 2 Title: Rationally designed modulators of the amyloid-beta aggregation cascade. Project leader: Dr. David Baker, Professor, Department of Biochemistry, University of Washington, and Investigator, Howard Hughes Medical Institute Learn More
  • Project 3 Title: Standardized Brain Imaging, Spinal Fluid Analysis, and Cognitive Data Collection in ACT Subjects
    Project leader: Dr. Thomas Grabowski, Professor, Departments of Radiology and Neurology, University of Washington, and Director, Integrated Brain Imaging Center, University of Washington Learn More

A collaboration with the Pacific Northwest Udall Center (PANUC), which is based at Stanford University, to study the genetic risk factors for cognitive impairment in Parkinson disease. (Team Members)

The Adult Changes in Thought Study, a 30-year longitudinal study to identify lifestyle factors of risk and resilience in the development of memory loss and dementia. (Team Members)

The Therapeutic Pipeline Project, an effort made possible by a $6 million gift from the Ellison Foundation, aims to accelerate Alzheimer's disease treatment and improve genetic counseling in the exome sequencing era.

Clinical trials and studies geared towards symptom prevention, early diagnosis, and treatment of Alzheimer's disease. (Team Members)

 

Researchers, clinicians, and students interested in neurological conditions that lead to dementia may be interested in this curated list of resources. The UW Memory and Brain Wellness Center website aims to be of interest to all who investigate or treat age-related, genetic, or acquired neurodegenerative disorders; as well as related issues of brain health and dementia. To submit or provide updates on events and programs of interest in this research specialty at the UW, please email gwanucha@uw.edu

Conferences

All national and international research conferences related to Alzheimer's disease and frontotemporal degeneration (FTD)—AlzForum’s Conference Calendar.

Comprehensive Conference Coverage from AlzForum

 

"Diffusion Tensor Imaging (DTI) is a way of taking MRI images that is sensitive to the way water diffuses in the brain. If there is any sort of damage to the white matter of the brain, we see increased or disordered diffusion. Additionally, water diffuses quickly along the white matter pathways of the brain, so DTI can allow us to see the pathways that connect different parts of the brain." -Dan Peterson, UW Integrated Brain Imaging Center.

 

New Resources

 

Thioflavin-S staining of a brain tissue sample reveals amyloid plaques and neurofibrillary tangles. Credit Allen Institute

Aging, Dementia and TBI Study- A detailed neuropathologic, molecular and transcriptomic characterization of brains of control and TBI exposure cases from a unique aged population-based cohort from the Adult Changes in Thought (ACT) study. The open-access database was developed by a consortium consisting of the University of Washington, Kaiser Permanente Washington Health Research Institute (formerly the Group Health Research Institute), and the Allen Institute for Brain Science.

 

 

Academic Event Directory

 

UW Medicine Grand Rounds and video archive

UW Neurology Grand Rounds, webcasts, and video archive

UW Geriatric Grand Rounds and Geriatric Journal Club Calendar

UW Psychiatry Grand Rounds, webcasts, and video archive

UW Pathology Events, Lectures & Seminars

UW Neuroscience Seminar Series 2016

Videos of Paul G. Allen Alzheimer's Symposium Lectures -Seattle Allen Brain Institute

Lecture videos-Allen Distinguished Investigators

Events -Seattle Allen Brain Institute

Quarterly Speaker Series presented by the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, the Genetic Approaches to Aging Training Grant, and the UW Healthy Aging and Longevity (HALo) Research Institute

UW’s Science in Medicine Lectures

UW Medicine Neurosciences Institute YouTube

UW Medicine Health YouTube

 

For Students

Grey Matters Journal— An undergraduate neuroscience journal at the University of Washington. Join the staff members who publish a quarterly journal that is written, edited, illustrated, and produced entirely by undergraduate students. Aside from the journal, Grey Matters also hosts events such as our annual Evening with Neuroscience, an event dedicated to helping the public learn more about neuroscience from some of the most accomplished individuals in the field.

 

Highlighted Talks by UW Medicine Researchers + Visitors

 

UW Pathology's Dirk Keene served on the first NIH consensus panel to define neuropathological criteria for diagnosis of Chronic Traumatic Encephalopathy (CTE) pathology, which produced this visualizion of tau tangles in postmortem brain tissue of professional football players. Acta Neuropathologica, Vol 131. Jan 2016. McKee et al.

Huntington's Disease: An Update on the Most Curable Incurable Brain Disorder [Video]
Presented By: Jeff Carroll, Ph.D.
Date: 02/09/2017

 

Neuroinflammation in Alzheimer's Disease [Video]
Presented By: Anthony Lyons, Ph.D.
Date: 02/02/2017

 

Serendipity, Discovery and Neurology [Video]
Presented By: Bruce Ransom, M.D., Ph.D.
Date: 01/05/2017

 

Adaptive immunity in post-stroke dementia [Video]
Presented By: Marion Buckwalter, M.D., Ph.D.
Date: 12/08/2016

 

Lifetime Perspective on Adult Hydrocephalus [Video]
Presented By: Michael A. Williams, M.D.
Date: 10/27/2016

 

Feeding Tubes in Advanced Neurological Illness: Basic Care or Extraordinary Measure? [Video]
Presented By: Timothy E. Quill, M.D.
Date: 10/13/2016

 

Conducting Clinical Trials in Cognitive Loss and Dementia: Past Lessons & Futer Plan [Video]
Presented By: Mary Sano, Ph.D. (Mount Sinai - New York)
Date: 10/06/2016

 

Five New Things in Geriatrics [Video]
Presented By: Wayne McCormick, M.D.
Date: 07/21/2016

 

Blast-Related mTBI in Veterans: Complex Comorbidities and Clinical Outcomes [Video]
Presented By: Kathleen Pagulayan, Ph.D.
Date: 05/26/2016

 

Behavioral Interventions in Mild Cognitive Impairment (MCI) [Video]
Presented By: Vaishali Phatak, PhD, ABPP
Date: 01/21/2016

 

150 Years of Neurogenetics [Video]
Presented By: Thomas D. Bird, M.D.
Date: 11/19/2015

 

5 New Things in Neuro-Palliative Care [Video]
Presented By: Claire J. Creutzfeldt, M.D.
Date: 09/10/2015

 

5 New Things: Dementia [Video]
Presented By: Kimiko Domoto-Reilly, M.D.
Date: 08/27/2015

 

Targeting Function and Neuroprotection with Exercise in Neurodegenerative Disease [Video]
Presented By: Ellen McGough, PT, Ph.D.
Date: 04/03/2015

 

PEARLS: A Community Based Intervention for Depression Treatment in Older Adults [Video]
Presented By: Mark Snowden, M.D., M.P.H.
Date: 01/02/2015

 

Blast-induce mild traumatic brain injury: The consequences of more than a decade at war [Video]
Presented By: David G. Cook, Ph.D.
Date: 12/05/2014

 

Future Directions for Behavioral Interventions Research in the Era of the NIMH RDoC [Video]
Presented By: Patricia Arean, Ph.D.
Date: 10/24/2014