The directed migration of cells within and between tissues is a fundamental process in animal development. In early embryos the germ layers move over one another and intercalate to form the body axes; later in development neural crest cells migrate throughout the body to give rise to a range of differentiated cell types and primordial germ cells home to the developing gonad. In the brain, neurons migrate from generative zones to the positions where they make their synaptic contacts. A number of human disease conditions and developmental abnormalities stem from defects in cell migration, and cell migration occurs inappropriately during cancer metastasis.
This course will highlight modern ideas about mechanisms of cell migration, from the basic subcellular events that generate and stabilize cellular protrusions to the diffusible attractants and repellants that orient migration.
MCB Faculty: Cecilia Moens, Jon Cooper