Signaling Mechanisms in Excitable Cells
Introduces biophysical properties of nerve and muscle cells. Topics include intrinsic electrical properties of neurons, ion channels, receptor signaling, calcium signaling, contraction of muscles, and synaptic function.
NOTE THAT CONJ 531 IS THE FIRST 5 WEEKS OF NEUBEH 504
HANDOUTS: Handouts will be given for each lecture. Extra copies of class handouts, homework and take-home exam will be accessible on our web page (see above).
Course Web Page: http://courses.washington.edu/PBIO504 contains at least:
|1||Introduction to cell membranes||Electrical properties of membranes||Electrical signaling proteins: ion channels|
|2||An electrical signal: the action potential||Molecular basis of ion channel function I: Mechanisms of permeation||Molecular basis of ion channel function II: Mechanisms of gating|
|3||Mechanism of Ligand Gating: Principles||Mechanism of Ligand Gating: Molecular Basis||Membrane ligands|
|4||Mechanism of Ligand Gating: Multimodal Channels||Basis of muscle contraction||Force production by muscle myosin|
|5||Non-muscle motor proteins||“Unconventional’ motors and motility||Excitation-contraction coupling|