Signal Transduction from the Cell Membrane to the Nucleus

Course Number: 
CONJ 532
Course Type: 
Keystone
Currently Offered: 
Yes
Credits: 
1.5
Quarter: 
Autumn
Weeks: 
6-10
Meeting Time: 
MWF 1230-120
Location: 
UW
Instructor (MCB Faculty): 
Beavo, Joseph
Instructor (MCB Faculty): 
Storm, Daniel
Course Description: 

Intracellular signaling pathways leading from cell membrane receptors to nucleus. Pathways activated by seven transmembrane receptors and G-proteins, insulin/PI3 kinase, nitric oxide and WNTs and mechanisms of signal termination. Cytokine/Jak/Stat signaling and role of subcellular localization in signal transduction.

Required Text: 
There will be no required textbook for the course although you may find Cooper's "The Cell" or Lodish's "Molecular Cell Biology" or Pollard's "Cell Biology" helpful if you do not have a good background in signal transduction.
Course requirements, examinations and grading: 

Please note, your grade will be 50% determined by a final exam and 50% determined by answers to a weekly question you will be asked to submit. These questions will be based partly on lecture material and partly on papers that you will be asked to read. There will be one major exam, the final. This exam will be in the form of short answer essay questions. 

Course Web site: http://courses.washington.edu/conj532/

Sample Syllabus:

Week Mon Weds Fri
  1 Introduction to course Basic elements of signal transduction systems Protein-protein coupling and G protein coupling
  2 cAMP pathway and compartmentalized signaling Nitric oxide/CO/cGMP signaling pathways Insulin, IGF-1, IRS signaling
  3 Cross talk between cAMP and MAPK signaling Molecular and Cellular Basis of Memory Formation I Molecular and Cellular Basis of Memory Formation II
  4 Chemosensory mechanisms Cytokine/Jak/Stat signaling pathways

Proteolysis and signal transduction: Hedgehog and Notch signaling pathways

  5

Proteolysis and signal transduction:  WNT –1 signaling

Signal Transduction Therapies Signaling pathways in developmental biology
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Keystone Area: 
Cell Signaling & Cell/Environment Interactions
Elective Area: 
Cancer Biology
Molecular Structure & Computational Biology
Neuroscience