Signal Transduction from the Cell Membrane to the Nucleus
Intracellular signaling pathways leading from cell membrane receptors to nucleus. Pathways activated by seven transmembrane receptors and G-proteins, insulin/PI3 kinase, nitric oxide and WNTs and mechanisms of signal termination. Cytokine/Jak/Stat signaling and role of subcellular localization in signal transduction.
Please note, your grade will be 50% determined by a final exam and 50% determined by answers to a weekly question you will be asked to submit. These questions will be based partly on lecture material and partly on papers that you will be asked to read. There will be one major exam, the final. This exam will be in the form of short answer essay questions.
Course Web site: http://courses.washington.edu/conj532/
|1||Introduction to course||Basic elements of signal transduction systems||Protein-protein coupling and G protein coupling|
|2||cAMP pathway and compartmentalized signaling||Nitric oxide/CO/cGMP signaling pathways||Insulin, IGF-1, IRS signaling|
|3||Cross talk between cAMP and MAPK signaling||Molecular and Cellular Basis of Memory Formation I||Molecular and Cellular Basis of Memory Formation II|
|4||Chemosensory mechanisms||Cytokine/Jak/Stat signaling pathways||
Proteolysis and signal transduction: Hedgehog and Notch signaling pathways
Proteolysis and signal transduction: WNT –1 signaling
|Signal Transduction Therapies||Signaling pathways in developmental biology|