The Dynamic Chromosome

Course Number: 
CONJ 533
Course Type: 
Keystone
Currently Offered: 
Yes
Credits: 
1.5
Quarter: 
Spring
Weeks: 
1-5
Meeting Time: 
TTh 320-440
Location: 
FHCRC
Instructor (MCB Faculty): 
Henikoff, Steven
Class Size: 
30 students, with preference given to MCB students
Course Description: 

This course is a graduate level introduction to the chromosome, viewing it as the ultimate organelle. Topics this year will focus on the functions and evolution of chromosomal elements as well as the mechanisms that ensure the maintenance and propagation of chromosomes. The class will use a combination of lecture, literature review, and in-class discussion to explore genetic, biochemical, and cytological methods for defining our current knowledge about chromosomes. The course requires students to have taken undergraduate cell biology, biochemistry and genetics. Active participation in discussion is required.

Learning Objectives: 

Students should have a good understanding of the basic biology of the chromosome.  The will also become familiar with both the classic and current experimental techniques used to study various aspects of chromosome biology. 

Prerequisites: 
Students must have a basic understanding of molecular biology and basic techniques (ie: they should know what an immunoprecipitation is and what DNA is)
Required Text: 
The course material will be composed of original literature that will be assigned each class.
Course requirements, examinations and grading: 

There will be four problem sets and a class participation grade. Grades will be based on problem sets and class participation with the following distribution.

  • Problem Set 1, 20%
  • Problem Set 2, 20%
  • Problem Set 3, 20%
  • Problem Set 4, 30%
  • Participation, 10%

Course web page:  http://libguides.fhcrc.org/conj533

Sample Syllabus:

Tuesday

 

Thursday

Week

Date

Instructor/Topic

 

Date

Instructor/Topic

1

9/25

Sue Biggins

Chromosome Intro

 

9/27

Sue Biggins

Replication

2

10/2

Steve Henikoff

Epigenetics

 

10/4

Steve Henikoff

Nuclear organization

3

10/9

Sue Biggins

Cohesion and Condensation

 

10/11

Sue Biggins

Centromeres

4

10/16

Sue Biggins

Telomeres 

 

10/18

Harmit Malik

Evolution of mobile elements and chromosome structure

5

10/23

Sue Biggins

Genome Integrity

 

10/25

Sue Biggins

meiosis

Areas of Interest: 
Gene Expression, Cell Cycle & Chromosome Biology
Keystone Area: 
Gene Expression, Cell Cycle & Chromosome Biology
Elective Area: 
Cancer Biology
Genetics, Genomics & Evolution