Mechanism of Transcriptional Regulation

Course Number: 
CONJ 537
Course Type: 
Keystone
Currently Offered: 
Yes
Credits: 
1.5
Quarter: 
Autumn
Weeks: 
6-10
Meeting Time: 
TTh 320-440
Location: 
FHCRC
Instructor (MCB Faculty): 
Tsukiyama, Toshio
Class Size: 
30
Course Description: 

This course covers a broad overview of mechanisms for transcriptional regulation.  It covers basic mechanisms of transcriptional regulation in prokaryotes, eukaryotes, and transcriptional regulation through chromatin.

Instructors: T. Tsukiyama, S. Hahn, S. Tapscott

Learning Objectives: 

1) Understand the basic rules of transcriptional regulation, including how transcriptional activators function. 

2) Understand how cis-elements, such as promoters and enhancers, function.

3) Understand how chromatin structure is regulated for transcriptional control.

Prerequisites: 
Graduate student status or permission of instructor
Course requirements, examinations and grading: 

Course attendance, participation in discussion in class, homework.

Course web page: http://libguides.fhcrc.org/transcription

Sample syllabus

Instructor

Lecture topic

Concepts

Steve Hahn

Transcriptional regulatory mechanisms in Prokaryotes

Basic rules of transcriptional regulation by activators

Steve Hahn

RNA pol II transcription and regulation I, II

Mechanisms of transcriptional regulation for RNA polymerase II by general transcription factors and activators

Toshio Tsukiyama

Chromatin and transcription: General overview

Mechanisms by which chromatin structure affects transcription

Toshio Tsukiyama

Histone Modifying enzymes

Transcriptional regulation by histone modifications

Toshio Tsukiyama

ATP-dependent chromatin remodeling

Transcriptional regulation by chromatin remodeling factors

Stephen Tapscott

Promoter-specific and regional regulation of transcription

Mechanisms of eukaryotic transcriptional regulation

 

Stephen Tapscott

Dynamic and complex patterns of gene expression

Transcriptional regulation in cell differentiation and development

Areas of Interest: 
Gene Expression, Cell Cycle & Chromosome Biology
Elective Area: 
Cancer Biology