Mechanism of Transcriptional Regulation
Course web page: http://libguides.fhcrc.org/transcription
Dates, days and times: 10/30/12 – 12/4/12; Tues. & Thurs.; 3:20-4:40pm
Location: FHCRC B072/074
Class size: 30
Course description: This course covers a broad overview of mechanisms for transcriptional regulation. It covers basic mechanisms of transcriptional regulation in prokaryotes, eukaryotes, and transcriptional regulation through chromatin.
Learning objectives:
1) Understand the basic rules of transcriptional regulation, including how transcriptional activators function.
2) Understand how cis-elements, such as promoters and enhancers, function.
3) Understand how chromatin structure is regulated for transcriptional control.
Prerequisites: Graduate student status or permission of instructor
Course materials and/or textbooks: No textbooks are used. Selected literature is linked on the course website.
Course requirements, examinations and grading: Course attendance, participation in discussion in class, homework.
Sample syllabus
|
Instructor |
Lecture topic |
Concepts |
|
Steve Hahn |
Transcriptional regulatory mechanisms in Prokaryotes |
Basic rules of transcriptional regulation by activators |
|
Steve Hahn |
RNA pol II transcription and regulation I, II |
Mechanisms of transcriptional regulation for RNA polymerase II by general transcription factors and activators |
|
Toshio Tsukiyama |
Chromatin and transcription: General overview |
Mechanisms by which chromatin structure affects transcription |
|
Toshio Tsukiyama |
Histone Modifying enzymes |
Transcriptional regulation by histone modifications |
|
Toshio Tsukiyama |
ATP-dependent chromatin remodeling |
Transcriptional regulation by chromatin remodeling factors |
|
Stephen Tapscott |
Promoter-specific and regional regulation of transcription |
Mechanisms of eukaryotic transcriptional regulation
|
|
Stephen Tapscott |
Dynamic and complex patterns of gene expression |
Transcriptional regulation in cell differentiation and development |
- People
- Current Students
- Prospective Students
- Areas of Interest
- Affiliated Programs
- Training Grant
