Protein Structure, Modification and Regulation
We will provide an overview of general principles of protein structure, including (i) forces and interactions that contribute to folding, dynamics and stability, (ii) the structural and functional effects of post-transcriptional and post-translational splice variation, (iii) covalent chemical modification of protein side chains, (iv) the functional effects of ligand binding via cooperativity and allostery, and and (v) diversification of protein fold and function during evolution.
Location: FHCRC Day Campus, Weintraub Bldg., Rm. B1-074/76
Time: T,TH 3:30 - 4:40
Readings: Text and selected papers from primary literature