Human Pathogenic Viruses
Course web page: http://libguides.fhcrc.org/mcb532
Last Offered: Fall, 2010
Next Offered: Fall, 2012. Will be offered every other year.
Dates, days and times: (9/25 – 12/6; Tues. & Thurs. 1:30-3:00pm)
Location: FHCRC, Weintraub Building, B1-072/074 (across the hall from the library)
Class size: 27 maximum
Course description: Students will learn basic and advanced concepts in virology by focusing on major groups of human pathogenic viruses. The major emphasis will be on virus replication, evolution, and pathogenesis. Each class period consists of lecture and a discussion of a paper from the primary literature related to the previous lecture.
Learning objectives: At the end of this course, students should:
- Understand concepts of replication and pathogenesis among diverse families of pathogenic human viruses.
- Understand concepts in the evolution of viruses and their interactions with their hosts as well as related concepts of viral reservoirs and viral emergence.
- Understand the importance of viruses in public health
Prerequisites: Graduate student in MCB, Microbiology, or Pathobiology. Other departmental graduate students will be considered if there is space. Background in basic molecular and cellular biology is assumed. No previous course in virology is assumed.
Course materials and/or textbooks: No textbooks are used. Course material can be downloaded from the class website.
Course requirements, examinations and grading:
40%: class participation including paper discussions
30%: 3 to 4 problem sets will be assigned during the quarter
30% : final project
Syllabus: Discussion paper for each lecture is linked on the course web site
|
Instructor
|
Lecture topic |
Concepts |
|
Emerman |
Introduction to concepts in virology |
Background on basic concepts in virus replication and viral genes |
|
Emerman |
Viral quasispecies |
Background on concepts in viral genetics and evolution |
|
Emerman |
Retroviruses and HIV replication |
Genetic organization of retroviruses, life cycle of HIV, origins of HIV |
|
Emerman |
HIV Pathogenesis |
The HIV pandemic, models for AIDS pathogenesis, comparison of outcomes between different primate hosts |
|
Emerman |
Paramyxoviruses (Measles) |
General rules about negative-strand virus replication and measles in particular, concept of R0, measles pathogenesis and eradication issues. |
|
Emerman |
Orthomyxoviruses (Influenza part I) |
Replication of influenza, seasonal infections, phylogenetic analysis of influenza |
|
Emerman |
Orthomyxoviruses (Influenza part II) |
Origins of influenza pandemics, swine flu and bird flu and their dangers to humans |
|
Emerman |
Filoviruses (Ebola) |
Concept of virus reservoirs, replication and pathogenesis of filoviruses, |
|
Emerman |
Picornaviruses (Polio) |
General rules about positive-strand RNA virus replication, diversity and replication of picornaviruses, vaccine and eradication issues |
|
Emerman |
Alphaviruses |
Replication of viruses that cycle between insects and mammals, replication and evolution of alphaviruses, mechanisms of virus emergence by expanded host range of vectors.
|
|
OhAinle |
Dengue virus |
Mechanisms of pathogenesis by Dengue, evolution of dengue, public health issues |
|
Gale |
Hepatitis C Virus |
HCV replication and innate immunity |
|
Emerman |
Coronaviruses (SARS) |
SARS epidemic and molecular evolution, replication strategy of coronaviruses |
|
Galloway |
Papilloma and Polyoma viruses |
Replication of small DNA viruses, mechanisms of oncogenesis, vaccine correlates |
|
Smith |
Adenoviruses |
Replication of large DNA viruses and immunity |
|
Geballe |
Herpes Viruses |
Herpes virus replication, latency, and disease |
|
Emerman |
Poxviruses (Smallpox) |
Evolution of poxviruses, replication strategy of cytoplasmic DNA viruses, history of smallpox vaccination and eradication, possibilities of emerging poxviruses |
|
Etienne |
Emerging viruses |
Overall concepts on viral emergence and re-emergence |
|
Emerman |
Paleovirology |
Methods of detecting ancient viruses, implications of paleoviruses on modern immunity |
|
Emerman |
Prions |
How proteins can be transmissible agents, madcow disease, virology wrapup |
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