Human Pathogenic Viruses

Course Number: 
MCB 532
Course Type: 
Keystone
Currently Offered: 
No
Credits: 
3
Quarter: 
Autumn
Meeting Time: 
TTh 1:30-3:00
Location: 
FHCRC
Instructor (MCB Faculty): 
Emerman, Michael
Class Size: 
27
Course Description: 

Students will learn basic and advanced concepts in virology by focusing on major groups of human pathogenic viruses. The major emphasis will be on virus replication, evolution, and pathogenesis.  Each class period consists of lecture and a discussion of a paper from the primary literature related to the previous lecture.

Course offered every other year, Autumn Quarter of even years. Next offered 2014.

Learning Objectives: 

At the end of this course, students should:

  1. Understand concepts of replication and pathogenesis among diverse families of pathogenic human viruses.
  2. Understand concepts in the evolution of viruses and their interactions with their hosts as well as related concepts of viral reservoirs and viral emergence.
  3. Understand the importance of viruses in public health
Prerequisites: 
Graduate student in MCB, Microbiology, or Pathobiology. Other departmental graduate students will be considered if there is space. Background in basic molecular and cellular biology is assumed. No previous course in virology is assumed.
Required Text: 
No textbooks are used. Course material can be downloaded from the class website.
Course requirements, examinations and grading: 

40%: class participation including paper discussions

30%:  3 to 4 problem sets will be assigned during the quarter

30% : final project

Course web page: http://libguides.fhcrc.org/mcb532

Sample Schedule: Discussion paper for each lecture is linked on the course web site

Instructor

 

Lecture topic

Concepts

Emerman

Introduction to concepts in virology

Background on basic concepts in virus replication and viral genes

Emerman

Viral quasispecies

Background on concepts in viral genetics and evolution

Emerman

Retroviruses and HIV replication

Genetic organization of retroviruses, life cycle of HIV, origins of HIV

Emerman

HIV Pathogenesis

The HIV pandemic, models for AIDS pathogenesis, comparison of outcomes between different primate hosts

Emerman

Paramyxoviruses (Measles)

General rules about negative-strand virus replication and measles in particular, concept of R0, measles pathogenesis and eradication issues.

Emerman

Orthomyxoviruses (Influenza part I)

Replication of influenza, seasonal infections,  phylogenetic analysis of influenza

Emerman

Orthomyxoviruses (Influenza part II)

Origins of influenza pandemics, swine flu and bird flu and their dangers to humans

Emerman

Filoviruses (Ebola)

Concept of virus reservoirs, replication and pathogenesis of filoviruses,

Emerman

Picornaviruses (Polio)

General rules about positive-strand RNA virus replication, diversity and replication of picornaviruses, vaccine and eradication issues

Emerman

Alphaviruses

Replication of viruses that cycle between insects and mammals, replication and evolution of alphaviruses, mechanisms of virus emergence by expanded host range of vectors.  

 

OhAinle

Dengue virus

Mechanisms of pathogenesis by Dengue, evolution of dengue, public health issues

Gale

Hepatitis C Virus

HCV replication and innate immunity

Emerman

Coronaviruses (SARS)

SARS epidemic and molecular evolution, replication strategy of coronaviruses

Sherer

Papilloma and Polyoma viruses

Replication of small DNA viruses, mechanisms of oncogenesis, vaccine correlates

Smith

Adenoviruses

Replication of large DNA viruses and immunity

Geballe

Herpes Viruses

Herpes virus replication, latency, and disease

Emerman

Poxviruses (Smallpox)

Evolution of poxviruses, replication strategy of cytoplasmic DNA viruses, history of smallpox vaccination and eradication, possibilities of emerging poxviruses

Emerman

Paleovirology

Methods of detecting ancient viruses, implications of paleoviruses on modern immunity

Emerman

Prions

How proteins can be transmissible agents, madcow disease, virology  wrapup

Areas of Interest: 
Microbiology, Infection & Immunity
Keystone Area: 
Microbiology, Infection & Immunity
Elective Area: 
Cancer Biology
Genetics, Genomics & Evolution