Biological Basis of Neoplasia
This course allows students to gain experience in applying the several disciplines which comprise cellular and molecular biology toward a deeper understanding of a complex biological problem: neoplastic change. The course consists of a series of lectures and discussion meetings to introduce students to the major themes in research in the cellular and molecular biology of neoplastic change. They cover principal molecular mechanisms responsible for tumor initiation and progression, with a specific emphasis on intracellular signaling, DNA repair mechanisms, cell cycle checkpoints and loss of normal tissue homeostasis. The latest state of research in specific arrears of Cancer Biology will be presented by invited scientists, who are the experts in the relevant fields. The discussion meetings will concentrate on selected major papers in cancer biology and they will be presented and discussed by the students with the help and guidance of the instructors.
This course will introduce students to the current knowledge on the mechanisms of cellular transformation, tumor initiation and progression.
Students will be evaluated based on their participation (20% of the grade), quality of their chosen research paper presentation (30% of the grade), overall group discussions (20% of the grade), and on a written 1-2 pages research grant proposal in their favorite field of Cancer Biology, which will be required at the end of the course (30% of the grade).
Course web site: http://libguides.fhcrc.org/neoplasia
|1||Introduction: Genetic basis of cancer||Oncogenes|
|2||Tumor Suppressors||Molecular Basis of Cancer Therapy and Resistance|
|3||Prostate Cancer||Presentation and discussion of research paper on prostate cancer|
|4||HPV and squamous cell carcinoma||Presentation and discussion of research paper on skin cancer|
|5||Molecular Pathogenesis of Colorectal Cancer||Presentation and discussion of research paper on colorectal cancer|
|6||MicroRNAs and cancer||Presentation and Discussion of Research Paper on microRNAs in Cancer|
|7||Hemotopoietic Malignancies||Presentation and Discussion of Research Paper on Hematopoietic cancer|
|8||Pancreatic Cancer||Presentation and Discussion of research paper on pancreatic cancer|
|9||Cell cycle control and ubiquitin-mediated proteolysis||Presentation and Discussion of research paper on cell cycle control in cancer|
|10||Mutator phenotype: Nuclear and mitochondrial mutations in carcinogenesis||Presentation and discussion of research paper on role of mutations in human cancer|