Cell Biology of Human Pathogens and Disease

Course Number: 
Course Type: 
Currently Offered: 
Meeting Time: 
MW 10:30-12:20 PM
Instructor (MCB Faculty): 
Grundner, Christoph
Instructor (non-MCB Faculty): 
Kevin Hybiske
Class Size: 
Course Description: 

The goal of this course is to expose graduate students to important concepts in cell biology as they relate to infectious disease and host-pathogen interactions. The emphasis will be on understanding the primary literature and learning how experiments in cell biology are designed, performed, and interpreted. (Also see Dr. Kevin Hybiske for additional instructor profile.)

Learning Objectives: 
  • Understand principles of cell biology including the function of cellular organelles, RNA and protein trafficking, secretion, extracellular matrix, cell division, apoptosis, and signal transduction.
  • Understand how basic principles of cell biology apply to host pathogen interactions, using pathogen examples from the virology, bacteriology, and parasitology literature.
  • Understand how experiments in cell biology are designed, carried out, and interpreted.
  • Learn about new advances in the cell biology of pathogens and disease.
  • Do a short presentation on a paper from the primary literature that illustrates principles of cell biology of pathogens or disease.
Students who are not in the Pathobiology graduate program should email christoph.grundner@seattlebiomed.org to confirm adequate preparation and to get permission to take the course. Once permission has been granted by the instructor, students will need to email pabio@u.washington.edu to get an add code for registration. Enrollment for non-Pathobiology students will be given out to PhD students in other programs in order of request.
Course requirements, examinations and grading: 

Grades are based on participation in class discussions (25%), one oral presentation (25%), a 1 week take-home midterm exam (25%), and a final exam (25%).

Areas of Interest: 
Microbiology, Infection & Immunity