Cell Biology of Human Pathogens and Disease

Course Number: 
PABIO 552
Course Type: 
Keystone
Currently Offered: 
Yes
Credits: 
4
Quarter: 
Winter
Meeting Time: 
MW 1030-1220 PM
Location: 
UW
Instructor (MCB Faculty): 
Grundner, Christoph
Instructor (non-MCB Faculty): 
Malcolm Gardner
Class Size: 
14
Course Description: 

The goal of this course is to expose graduate students to important concepts in cell biology as they relate to infectious disease and host-pathogen interactions. The emphasis will be on understanding the primary literature and learning how experiments in cell biology are designed, performed, and interpreted. (Also see Dr. Malcolm Gardner for additional instructor profile.)

Learning Objectives: 
Understand principles of cell biology including the function of cellular organelles, RNA and protein trafficking, secretion, extracellular matrix, cell division, apoptosis, and signal transduction.
 
Understand how basic principles of cell biology apply to host pathogen interactions, using pathogen examples from the virology, bacteriology, and parasitology literature.
 
Understand how experiments in cell biology are designed, carried out, and interpreted.
 
Learn about new advances in the cell biology of pathogens and disease.
 
Do a short presentation on a paper from the primary literature that illustrates principles of cell biology of pathogens or disease.
 
Write a 5 page original, NIH-style grant proposal related to a topic covered in the course.
Prerequisites: 
Students who are not in the Pathobiology graduate program should email jais@u.washington.edu to confirm adequate preparation and to get permission to take the course. Please note that because the University could not assign this class a larger room, enrollment in this course may be strictly limited to 14 students (we are working on ways to fit 2 more students into the room). If we are limited to 14, this leaves space for only 7 students who are not in the Pathobiology PhD program. Enrollment for non-Pathobiology students will be given out to PhD students in other programs in order of request.
Course requirements, examinations and grading: 

Grades are based on a 1 week take-home midterm exam (30%); a final NIH-style grant proposal (30%); one oral presentation (15%); written assignment for alternate oral presentation session (5%); participation in class discussions (10%); and written critiques of other students' NIH-style grant proposal (done using pseudonyms to preserve anonymity; 10%).

Areas of Interest: 
Microbiology, Infection & Immunity