Tuberculosis

Course Number: 
PABIO 590A
Course Type: 
Ungraded
Currently Offered: 
Yes
Credits: 
1
Quarter: 
Spring
Meeting Time: 
Monday-Wednesday, 4-5:20pm, 04/27-05/13/2015
Location: 
UW/SLU, SEATTLE BIOMEDICAL RESEARCH INSTITUTE - MEZZANINE
Instructor (MCB Faculty): 
Sherman, David
Class Size: 
20
Course Description: 

This course will cover the subject of tuberculosis from multiple perspectives: epidemiology, pathogenesis, and host response.  It is appropriate for MPH, MS, and PhD students, in biomedical sciences and public health.  Students will learn about tuberculosis disease, its worldwide distributoin, current interventions (diagnostics, drugs, vaccines), and major foci of current research. 5-7 Weeks

Learning Objectives: 

After completing this course, the student will be able to explain:

  • Differences between active and latent tuberculosis,
  • Molecular mechanisms of TB pathogenesis and control,
  • The status of current TB interventions,
  • The research priorities for the next decade.
Prerequisites: 
Graduate students in Global Health, Pathobiology, MCB, Micro, and others in public health or biomedical research departments with a basic understanding of biochemistry, molecular genetics and immunology.
Required Text: 
No textbooks will be used. All course materials will be made available online at the class website.
Course requirements, examinations and grading: 

Students can choose to take this class for Credit/No Credit or for a grade:

Presentation on a relevant topic 50%
Class participation 50%

 

Lecture topic

Concepts

TB history and global epidemiology

Where did TB come from?

How did it spread?

Intro to HIV/TB co-infection

Intro to TB drug resistance

TB molecular genetics

The TB genome

Worldwide variability

The TB wiring diagram

TB pathogenesis

Disease progression and latency

Host response

TB interventions

Diagnostics

Drugs

Vaccines

Student presentations

Research priorities: Diagnostics, drugs, vaccines

Student presentations

Research priorities: Diagnostics, drugs, vaccines