Transcriptional Control in Human Disease

Course Number: 
PHCOL 535
Course Type: 
Elective
Currently Offered: 
Yes
Credits: 
3
Quarter: 
Spring
Meeting Time: 
Th 230-420
Location: 
UW
Instructor (MCB Faculty): 
Bomsztyk, Karol
Instructor (MCB Faculty): 
Wang, Edith
Course Description: 

Advanced consideration and discussion of the mechanisms regulating transcription/gene expression and of aberrant transcription factors which disrupt this process found in cancer and other human diseases.

Prerequisites: 
PHCOL 512 or permission of instructor
Course requirements, examinations and grading: 
Class Participation (50%)
 
Students are asked to research the relevant topics from the case study/scenario brainstorm session and are expected to discuss these topics in the next class.
 
Discussion Summaries (50%)
 
Students are required to write a 1-page summary of the discussion topics and paper analysis. Be sure to include what you thought were the most important and interesting pieces of information that you learned. The summary is due at the beginning of class before the next Topics discussion begins.

Course web site: http://courses.washington.edu/phcol535/

Sample Schedule:

Week Tues Thurs
 1 Transcription Machinery / Chromatin Structure Epigenetic Mechanisms / Experimental Techniques
  2 Topics Discussion (Epigenetics) Paper Analysis / Brainstorm New Topics
  3 Topics Discussion (Non-coding RNAs) Paper Analysis / Brainstorm New Topics
  4 Topics Discussion (Histone Variant) Paper Analysis
  5 Manuscript Review Response to Reviews
Areas of Interest: 
Gene Expression, Cell Cycle & Chromosome Biology
Elective Area: 
Gene Expression, Cell Cycle & Chromosome Biology