We are using mouse embryonic stem cell approaches to introduce novel genetic mutations into the PKA regulatory system and investigating the major physiological functions of this signal transduction cascade. The mouse allows a full complement of genetic manipulations and in most instances provides a relevant model of human physiology, behavior, and disease. We use genetic techniques to produce tissue-specific activation or inactivation of PKA subunits and AKAPs (PKA scaffolding proteins). The lab has also developed a chemical-genetic approach that will allow drug dependent control of kinase activity in specific cell types in vivo.
Taking Students: Yes
Available for Rotations Autumn, Winter, Spring, Summer
