Professor Greenberg is interested in the social activities of bacteria with a particular emphasis on how social behavior affects virulence of human pathogens and the evolution of social activities. He studies cell-to-cell communication in Pseudomonas aeruginosa and other Gram-negative bacteria, biofilm formation in P. aeruginosa and how to defeat the antibiotic tolerance exhibited by bacteria growing in biofilms, and he studies territoriality in the urinary pathogen Proteus mirabilis.