Research in the Klevit group is directed towards an understanding of molecular recognition, with an emphasis on protein-protein interactions that play important roles in human disease. We use a variety of structural, biochemical, molecular biological, and biophysical techniques, with a major emphasis on high resolution NMR spectroscopy and mass spectrometry. Furthermore, we collaborate with colleagues focused on functional aspects of the systems we study. Ongoing projects in the group include the following systems: BRCA1, the breast cancer susceptibility protein; protein ubiquitination in general; human small heat shock proteins alpha-B crystallin and HSP27; and PhoQ, a virulence factor in pathogenic bacteria.
