Rini Kasinathan

Fred Hutchinson Cancer Research Center, 

Division of Basic Sciences

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Entry Quarter: Summer 2015

Lab Information

Advisor: Harmit Malik
Box: 358080/A2-025 206-667-4512


The following publications were retrieved from PubMed:

DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis.

Young JM, Whiddon JL, Yao Z, Kasinathan B, Snider L, Geng LN, Balog J, Tawil R, van der Maarel SM, Tapscott SJ.

PLoS Genet. 2013 Nov; 11(9)e1003947

akirin is required for diakinesis bivalent structure and synaptonemal complex disassembly at meiotic prophase I.

Clemons AM, Brockway HM, Yin Y, Kasinathan B, Butterfield YS, Jones SJ, Colaiácovo MP, Smolikove S.

Mol Biol Cell. 2013 Apr; 7(24)1053-67

Research Summary

Centromere drive is a theory that explains the rapid evolution of “selfish” centromeric DNA, which maximizes its transmission during asymmetric female meiosis. In response, centromeric binding proteins are found to evolve rapidly in order to prevent the adverse effects of centromere drive. Though this theory explains the evolution of centromeric DNA and proteins, few examples of centromere drive have been illustrated. Using a D. melanogaster model, I am characterizing the basis of centromere drive.