Fred Hutchinson Cancer Research Center,
Division of Basic Sciences
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
The following publications were retrieved from PubMed:
Kasinathan B, Ahmad K, Malik HS.
Genetics. 2017 Sep; 1(207)49-51
Young JM, Whiddon JL, Yao Z, Kasinathan B, Snider L, Geng LN, Balog J, Tawil R, van der Maarel SM, Tapscott SJ.
PLoS Genet. 2013 Nov; 11(9)e1003947
Clemons AM, Brockway HM, Yin Y, Kasinathan B, Butterfield YS, Jones SJ, Colaiácovo MP, Smolikove S.
Mol Biol Cell. 2013 Apr; 7(24)1053-67
Centromere drive is a theory that explains the rapid evolution of “selfish” centromeric DNA, which maximizes its transmission during asymmetric female meiosis. In response, centromeric binding proteins are found to evolve rapidly in order to prevent the adverse effects of centromere drive. Though this theory explains the evolution of centromeric DNA and proteins, few examples of centromere drive have been illustrated. Using a D. melanogaster model, I am characterizing the basis of centromere drive.