Kyle Hess

University of Washington, 

Genome Sciences

Biophysical and Structural Biology

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution

Entry Quarter: Autumn 2016

Lab Information

Advisor: Judit Villen


The following publications were retrieved from PubMed:

Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals.

Hess K, Oliverio R, Nguyen P, Le D, Ellis J, Kdeiss B, Ord S, Chalkia D, Nikolaidis N.

Sci Rep. 2018 Mar 23; 1(8)5082

Research Summary

Rapid advances in DNA sequencing have unearthed millions of mutations in humans, many of which may impact protein structure and function. My research aims to accelerate variant annotation by coupling complex mutational libraries with mass spectrometry-based technologies to directly assess the impact of amino acid mutations on protein structure and function at a proteome-wide scale.