University of Washington,
Biophysical and Structural Biology
Cell Signaling & Cell/Environment Interactions
Genetics, Genomics & Evolution
The following publications were retrieved from PubMed:
Hess K, Oliverio R, Nguyen P, Le D, Ellis J, Kdeiss B, Ord S, Chalkia D, Nikolaidis N.
Sci Rep. 2018 Mar 23; 1(8)5082
Rapid advances in DNA sequencing have unearthed millions of mutations in humans, many of which may impact protein structure and function. My research aims to accelerate variant annotation by coupling complex mutational libraries with mass spectrometry-based technologies to directly assess the impact of amino acid mutations on protein structure and function at a proteome-wide scale.