Primary focus is in the development and application of technologies and approaches to capture long-range contiguity of genomic sequence information using high-throughput sequencing. These methods can then aid in the interrogation of structural and haplotype information throughout the genome, including repetitive, or other "difficult" regions, as well as provide a sequence scaffolding to be used in de novo genome assembly.
Secondary focus is the development and application of technologies and approaches to capture epigenetic information across the genome. Particularly from limited numbers of cells to allow the interrogation of the epigenomic landscape from the early stages of development as well as samples of limited quantity such as a tumor biopsy.
Copyright © 2003-2013 Molecular & Cellular Biology Program, University of Washington
Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed