Aitchison, John

Faculty Profile

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[field_fname-formatted] [field_lname-formatted]
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Office Location: 

Institute for Systems Biology
401 Terry Ave N, Seattle

Office Phone: 
(206) 732-1344

Research Summary: 

Dr. Aitchison holds faculty appointments at both Institute for Systems Biology and Seattle Biomedical Research Institute.  His work is focused on developing and applying systems biology approaches to the study of fundamental cell biology.  Systems under study include understanding how viruses such as Dengue control cellular functions, nuclear transport and peroxisome biogenesis.  As a student, he studied biochemistry, specializing in biotechnology and genetic engineering, at McMaster University in Ontario, Canada. There, in the laboratory of Dr. Richard Rachubinski, he investigated the molecular mechanisms responsible for sorting proteins into peroxisomes. After receiving his Ph.D., Dr. Aitchison performed his postdoctoral work in the l aboratory of Nobel Laureate Dr. Günter Blobel at Rockefeller University. In Dr. Blobel's lab, Dr. Aitchison applied classic cell biology techniques and yeast genetics to the study of protein import into the nucleus. During this time, he began to apply large-scale proteomics to the problem, which he continued as an Assistant Professor in the Faculty of Medicine and Dentistry at the University of Alberta until joining the ISB in 2000. Dr. Aitchison also holds affiliate appointments at the University of Washington, University of Alberta, and University of British Columbia. He is a member of the Molecular and Cellular Biology and Biological Physics, Structure and Design Graduate Programs at the University of Washington. Since joining ISB in 2000, his laboratory has been exploiting systems based assays and analyses to reveal and understand complex biological phenomena.

Short Research Description: 
Complex molecular machines, cell biology, influenza, dengue
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Gene Expression, Cell Cycle & Chromosome Biology
Microbiology, Infection & Immunity
Molecular Structure & Computational Biology
<p> systems biology, cell biology, organelle biogenesis, peroxisome, nuclear pore complex, nuclear transport, nuclear organization, chromatin, transcriptional regulation, transcription, nucleus, karyopherin, importin, nucleoporin, proteomics, microarrays, Complex molecular machines, influenza</p>

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