andrewms

The Scharenberg laboratory is interested in signal transduction mechanisms and cation channel function in the immune system, and engineering of homing endonucleases for gene repair applications in inherited immune deficiencies. Current effort is centered in two areas:

1) Signal transduction in immune cells, particularly signaling pathways affected in primary immune deficiencies and those involving ion channels.

2) Use of homing endonucleases in targeted gene repair of genes responsible for primary immune deficiencies. A new approach to gene therapy involves targeted repair of a gene via the induction of a double strand break at or near the mutation site.