K-072, Health Sciences Center
The Preston laboratory studies the causes and consequences of mutation in human disease. We are particularly interested in how organisms maintain their genomic integrity and how this integrity may be perturbed during disease progression. A central theme of our research is understanding mechanisms that govern faithful DNA synthesis with a focus on defining the biologic significance of replication fidelity in nature. Diseases impacted by fidelity that we are studying in the lab include cancer, AIDS and aging.
Copyright © 2003-2013 Molecular & Cellular Biology Program, University of Washington
Fred Hutchison Cancer Research Center | University of Washington
Institute for Systems Biology | Seattle Biomed