The Preston laboratory studies the causes and consequences of mutation in human disease. We are particularly interested in how organisms maintain their genomic integrity and how this integrity may be perturbed during disease progression. A central theme of our research is understanding mechanisms that govern faithful DNA synthesis with a focus on defining the biologic significance of replication fidelity in nature. Diseases impacted by fidelity that we are studying in the lab include cancer, AIDS and aging.
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Fred Hutch | University of Washington
Institute for Systems Biology (ISB)| Center for Infectious Disease Research