Berg, Celeste

Faculty Profile

First Name: 
Celeste
Last Name: 
Berg
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Title: 
Professor
Primary Institution: 
UW
Department/Division: 
other
Department/Division: 
Genome Sciences
E-Mail: 
Mail/Box #: 

355065

Office Location: 

Foege S433C

Office Phone: 
(206) 543-1677
Alternate Phone: 
(206) 543-1622
Research

Research Summary: 

What are the mechanisms and molecules that control development? Genetic and genomic studies reveal that developmental processes are similar in all animals. We are using Drosophila to investigate how flat epithelial sheets are patterned into distinct cell types and how these cell types change shape and rearrange to make a pair of simple tubes called dorsal appendages (Dorman et al. 2004; reviewed by Berg 2005). This process occurs in the follicle cell layer that surrounds the oocyte and is tied to establishing dorsal/ventral polarity in the embryo. In vertebrates, tube formation produces the heart, kidneys, lungs, gut, and neural tube; dorsal appendage formation resembles these more complex processes but is easier to study because it does not involve cell division or cell death. We also have sophisticated genetic tools for manipulating gene function, a culture system for imaging events live, and a battery of markers for following the fate and behavior of the cells.

Short Research Description: 
Functional genomics of patterning and morphogenesis
Areas of Interest: 
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Genetics, Genomics & Evolution
Keywords: 
<p> developmental genetics, pattern formation, organ formation, cell signaling, mechanisms of evolution, functional genomics</p>
Publications


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